Compare Erygel vs. Minocycline

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Akne-Mycin (Erythromycin)

Prescription only

Solodyn (Minocycline)

Prescription only
Topical treatment for acne.

Akne-Mycin (Erythromycin) is a very common acne treatment you apply to the skin that may work better when combined with other topical medicines.

3.4/ 5 average rating with 93 reviewsforErygel
Treats bacterial infections.

Solodyn (Minocycline) is an effective way to treat certain skin infections, acne, and rosacea, but you'll need to use barrier methods of birth control since it can make birth control pills less effective and cause birth defects.

4.0/ 5 average rating with 17 reviewsforMinocycline
Upsides
  • Applying erythromycin to the skin reduces the amount of acne bacteria and "calms" the skin down (lowers the inflammatory response) in acne.
  • Available in a gel formulation which may be better if your skin is very oily.
  • Better choice if you're pregnant. erythromycin is categorized as pregnancy Category B (likely safe) as compared to similar topical medicines that are Category C (weigh risks vs benefits).
  • Clinical studies show it's effective against MRSA, a common skin infection, and it's commonly used to treat acne and rosacea.
  • Available as a generic, so it should be reasonably priced.
  • Solodyn (Minocycline) is less likely to cause sunburn than other tetracycline antibiotics.
  • Bacteria are less likely to become resistant to Solodyn (Minocycline) than other tetracycline antibiotics.
Downsides
  • There's a risk of irritation with anything you apply to your skin and this is no different. erythromycin, like other topical antibiotics, can cause skin irritation and may appear as redness, peeling, abnormal dryness or stinging, tightening, or burning sensations.
  • It's rare, that a serious allergic reaction would occur, but it's a good idea to test a small area of skin before using on any larger or sensitive areas
  • Studies show it works better when combined with other topical medicines to fight acne and reduce the risk of it losing its effectiveness over time.
  • Can cause severe inflammation of the large intestine (pseudomembranous colitis)
  • Stop using if you don't notice any improvement in your acne after 6-8 weeks. The most time you can use it is three months.
  • It can make birth control pills less effective, so people should use barrier methods of birth control like condoms or diaphragms while on Solodyn (Minocycline).
  • Can stain your teeth, mouth, and gums if you're using the tablets, or your skin if you're using the topical version, but this is temporary.
Used for
Dosage forms
  • Cream, gel, or ointment
  • Topical solution
  • Pill
  • Extended release
  • Extended release capsule
Price
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Reviews
93 reviews so far
46%
saidit'sworth it
34%
saiditworked well
19%
saidit'sa big hassle

Have you used Akne-Mycin (Erythromycin)?

Leave a review
17 reviews so far
53%
saidit'sworth it
59%
saiditworked well
18%
saidit'sa big hassle

Have you used Solodyn (Minocycline)?

Leave a review
Side effects
1possible side effects
  • Burning
    25%
See more detailed side effects
The Solodyn (Minocycline) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Allergic reaction
  • Skin irritation
    • Using other medicines or products that irritate the skin
    • Eczema
    • Extreme temperatures (hot or cold)
  • Development of more serious infections
See more detailed risks and warnings
  • Changes in teeth
    • Age 8 years or younger
  • Decreased effectiveness of birth control pills
    • Using oral birth control pills
  • Diarrhea from a superinfection (an infection that happens after, or in addition to, an earlier infection)
    • Long antibiotic treatment period
  • Rash
  • Sunburn
  • Harm to fetus
    • Women of childbearing age
See more detailed risks and warnings