Compare Estrace vs. Prefest

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Estrace
(estradiol)

Prefest
(estradiol / norgestimate)

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. Estrace (Estradiol) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.Relieves menopause symptoms and lowers your risk of osteoporosis. Prefest (Estradiol / Norgestimate) is effective at treating symptoms related to menopause and bone loss. It has a difficult dosing schedule to follow, but doesn't affect your cholesterol and triglyceride levels as much as other estrogen products.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Estrace
Best available price for 30 (1mg) tablets of estrace
Coupons for Prefest
Best available price for 30 (30 tablets) packages of prefest
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Estrace (estradiol)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Prefest (estradiol / norgestimate)?
Worth itNot sureNot worth it
Side effects
EstracePrefest

The Estrace FDA package insert doesn’t have numbers about how common side effects are.

More about Estrace side effects »
  • Headache 23%
  • Upper respiratory-tract infection 21%
  • Breast pain 16%
  • Back pain 12%
  • Abdominal pain 12%
  • Flu-like symptomsa-like symptoms 11%
  • Joint pain 9%
  • Vaginal bleeding (all) 9%
  • Menstrual cramps 8%
  • Sinus inflammation 8%
More Prefest side effects »
How it works
EstracePrefest
Estrace (Estradiol) is an oral medication that replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.Prefest (Estradiol / Norgestimate) is a combination oral medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norgestimate (a progestin) protects the uterus from damage.
Type of medication
EstracePrefest
Prescription onlyPrescription only
Available as
EstracePrefest
  • Pill
  • Pill
Used for
EstracePrefest
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
EstracePrefest
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Estrace (estradiol) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Prefest (estradiol / norgestimate) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Pain
EstracePrefest
  • Estrogens like Estrace (Estradiol) can increase the risk of gallbladder disease, sometimes needing surgery. Let your doctor know if you have nausea, vomiting, bloating, or severe stomach pain that won't go away.
No pain related info.
Weight
EstracePrefest
  • Can cause nausea, dizziness, bloating and breast tenderness.
  • Prefest (Estradiol / Norgestimate) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
Upsides and benefits
EstracePrefest
  • Estrace (Estradiol) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Doesn't expose your partner to estrogen during sexual acitivities like the vaginal estrogen creams.
  • Can help relieve symptoms of advanced prostate or breast cancer in some people.
  • Prefest (Estradiol / Norgestimate) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The norgestimate (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Doesn't affect your cholesterol levels as much as other estrogen treatments.
Downsides and risks
EstracePrefest
  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Estrace (Estradiol) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norgestimate (a progestin).
  • Dosing schedule can be hard to follow with the 2 different kind of pills (estrogen-only and estrogen/progestin pills).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
Tips from our pharmacists for people taking the medication
EstracePrefest
  • Take Estrace (Estradiol) exactly the way your doctor tells you since the dose and dosing cycle may be different depending on what you're being treated for.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment. If you’re taking Estrace (Estradiol) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause or non-estrogen medicine for bone loss).
  • Can cause nausea, dizziness, bloating and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Follow the dosing schedule exactly to take the estrogen-only and combination estrogen/progestin pills.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about EstraceSide effectsAlternativesFDA package insert
Have you used Estrace (estradiol)?
Worth itNot sureNot worth it
More about PrefestSide effectsAlternativesFDA package insert
Have you used Prefest (estradiol / norgestimate)?
Worth itNot sureNot worth it