Compare Estradiol Norethindrone vs. Combipatch

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Activella
(estradiol / norethindrone)

Combipatch
(estradiol / norethindrone patch)

Relieves menopause symptoms and lowers your risk of osteoporosis. Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.Treats low estrogen and relieves menopause symptoms. Combipatch (estradiol / norethindrone patch) is a twice weekly patch that effectively treats menopause and causes less blood clots or stroke than combination pills.
Reviews & ratings
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Have you used Activella (estradiol / norethindrone)?
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Have you used Combipatch (estradiol / norethindrone patch)?
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Side effects
Estradiol NorethindroneCombipatch
  • Breast Pain 24%
  • Upper Respiratory Tract Infection 18%
  • Headache 16%
  • Sinusitis 7%
  • Insomnia 6%
  • Back Pain 6%
  • Post-Menopausal Bleeding 5%
  • Uterine Fibroid 5%
  • Infection Viral 4%
  • Moniliasis Genital 4%
More Estradiol Norethindrone side effects »
  • Breast pain 18%
  • Menstrual cramps 15%
  • Back pain 6%
  • Nausea 4%
  • Flu like symptoms 2%
  • Abnormal pap smear 3%
  • Weakness 4%
  • Stomach pain 3%
More Combipatch side effects »
How it works
Estradiol NorethindroneCombipatch
Activella (Estradiol / Norethindrone) contains two hormones that work to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.Combipatch (estradiol / norethindrone patch) is a combination patch that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats. Norethindrone (a progestin) protects the uterus from damage.
Type of medication
Estradiol NorethindroneCombipatch
Prescription onlyPrescription only
Available as
Estradiol NorethindroneCombipatch
  • Pill
  • Patch
Used for
Estradiol NorethindroneCombipatch
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
Estradiol NorethindroneCombipatch
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Activella (estradiol / norethindrone) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Personal or family history of blood clots
  • Smoking
Detailed Combipatch (estradiol / norethindrone patch) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Weight
Estradiol NorethindroneCombipatch
  • Activella (Estradiol / Norethindrone) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
No weight related info.
Upsides and benefits
Estradiol NorethindroneCombipatch
  • Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Mimvey brand is less expensive than other estrogen/progestin combination medicines.
  • Twice weekly patch. Good for people who don't want to take daily pills.
  • Replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Less likely to cause blood clots or stroke than pills since patches contain a lower amount of hormones.
  • Good for women with an intact uterus.
  • You can bathe, shower, and swim while wearing the patch, as long as you don't rub the patch.
Downsides and risks
Estradiol NorethindroneCombipatch
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • More potential side effects than single ingredient medications since it exposes your whole body to two hormones.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • The patch can't be exposed to direct sunlight for long periods of time.
  • Can be expensive since it's only available as a brand name product.
Tips from our pharmacists for people taking the medication
Estradiol NorethindroneCombipatch
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin on your lower belly as directed by the manufacturer. Press the patch firmly in place for 10 seconds, especially around the edges. Don't place it at your waistline or on your breasts.
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to help prevent skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Combipatch (estradiol / norethindrone patch) is not intended to be used forever. Talk to your doctor regularly to see if you still need treatment.
Learn more
More about Estradiol NorethindroneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Activella (estradiol / norethindrone)?
Worth itNot sureNot worth it
More about CombipatchSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Combipatch (estradiol / norethindrone patch)?
Worth itNot sureNot worth it