Compare Estradiol Patch vs. Divigel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Estraderm
(estradiol patch)

Divigel
(estradiol gel)

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis. The Estraderm (Estradiol Patch) needs to be replaced twice a week, and it may have fewer side effects than oral estrogen pills.Relieves hot flashes due to menopause. Divigel (Estradiol Gel) comes in 3 different strengths. It uses lower doses of estrogen than other hormone replacements and is easy to use and apply.
Reviews & ratings
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Have you used Estraderm (estradiol patch)?
Worth itNot sureNot worth it

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Have you used Divigel (estradiol gel)?
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Side effects
Estradiol PatchDivigel
  • Breast pain 1%
  • Sinusitis 1%
  • Rhinitis 1%
  • Edema 7%
  • Abdominal pain 3%
  • Pain 1%
More Estradiol Patch side effects »
  • Nasopharyngitis 2%
  • Upper Respiratory Tract Infection 4%
  • Metrorrhagia 2%
  • Breast Tenderness 1%
More Divigel side effects »
How it works
Estradiol PatchDivigel
The Estraderm (Estradiol Patch) replaces an estrogen hormone, estradiol, that your body loses during and after menopause. Higher levels of estradiol relieve symptoms of low estrogen and menopause and prevent bone loss.Divigel (Estradiol Gel) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.
Type of medication
Estradiol PatchDivigel
Prescription onlyPrescription only
Available as
Estradiol PatchDivigel
  • Patch
  • Cream, gel, or ointment
Used for
Estradiol PatchDivigel
  • Hot Flashes And Night Sweats
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
Estradiol PatchDivigel
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Estraderm (estradiol patch) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
Detailed Divigel (estradiol gel) risks & warnings »
Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Alcohol
Estradiol PatchDivigel
No alcohol related info.
  • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
Weight
Estradiol PatchDivigel
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
Upsides and benefits
Estradiol PatchDivigel
  • The Estraderm (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Divigel (Estradiol Gel) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Good for people who don't want to take daily pills.
  • The pre-measured packets are easy to use and can be taken anywhere.
  • Fewer side effects than pills since there are lower amounts of estrogen in topical gels.
  • In studies, when people used low doses of Divigel (Estradiol Gel), their symptoms started to improve in 5 weeks and they felt continued improvement over 8 to 12 weeks. People using the highest doses of Divigel (Estradiol Gel) felt better in just 2 weeks.
  • Divigel (Estradiol Gel) is available in 3 strengths.
  • Very few women (less than 1%) had skin irritation from the medicine.
  • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
Downsides and risks
Estradiol PatchDivigel
  • Only comes in 2 strengths.
  • You need to replace the Estraderm (Estradiol Patch) twice a week, compared to other patches that are once a week.
  • Patch can fall off.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Estraderm (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use Divigel (Estradiol Gel) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.
Tips from our pharmacists for people taking the medication
Estradiol PatchDivigel
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Apply all of the gel in the packet to dry, clean, unbroken skin on the right or left upper thigh, alternating each day.
  • Don't put it on your face, breasts, vagina, or irritated skin.
  • Don't rub it in. Let the gel dry before dressing, and don't wash the application site for at least an hour.
  • Wash your hands well after applying the gel.
  • The gel is alcohol-based and flammable, so you shouldn't smoke while applying it.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about Estradiol PatchSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Estraderm (estradiol patch)?
Worth itNot sureNot worth it
More about DivigelSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Divigel (estradiol gel)?
Worth itNot sureNot worth it