Compare Estradiol Patch vs. Divigel

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Divigel (Estradiol gel)

Prescription only
Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.

The Estraderm (Estradiol Patch) needs to be replaced twice a week, and it may have fewer side effects than oral estrogen pills.

Relieves hot flashes due to menopause.

Divigel (Estradiol gel) is an easy to use medicine that comes in 3 different strengths. It uses lower doses of estrogen than other hormone replacements.

Upsides
  • The Estraderm (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Replaces estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • Good for people who don't want to or can't take daily pills.
  • Can take the easy to use, pre-measured packets anywhere.
  • Divigel (Estradiol gel) has fewer side effects than pills since there are lower amounts of estrogen in gels.
  • In studies, many women on the lowest dose started to feel better about a month after starting the medicine. People using the highest doses felt better in just 2 weeks.
Downsides
  • Only comes in 2 strengths.
  • You need to replace the Estraderm (Estradiol Patch) twice a week, compared to other patches that are once a week.
  • Patch can fall off.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Estraderm (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
  • Increases your risk of endometrial and breast cancer.
  • If you have your uterus, you have to use Divigel (Estradiol gel) with another hormone called progestin to lower your risk of uterine cancer.
  • Can't be used in people with liver problems.
  • It's possible to expose other people to the estrogen before it's absorbed by your skin.
  • Can be expensive since it's only available as a brand name product.
Used for
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Prevention of postmenopausal osteoporosis
Dosage forms
  • Patch
  • Gel
Price
No pricing information available
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Reviews
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Side effects
16possible side effects
  • Breast pain
    28%
  • URTI
    17%
  • Abdominal pain
    16%
  • Headache
    13%
  • Pain
    11%
  • Edema
    10%
  • Back pain
    9%
  • Depression
    8%
  • Flatulence
    7%
  • Leukorrhea
    7%
  • Pharyngitis
    7%
  • Nausea
    6%
  • Rhinitis
    6%
  • Arthralgia
    5%
  • Sinusitis
    5%
  • Pruritus
    3%
See more detailed side effects
5possible side effects
  • Breast pain
    6%
  • Unusual vaginal bleeding
    6%
  • Common cold
    4%
  • Lung infection
    2%
  • Yeast infection
    2%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Duration of use
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Harm to fetus
    • Women of childbearing age
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Using estrogen for more than one year
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Dementia
    • Age 65 or older
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings