Compare Estradiol Patch vs. Estring

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Estraderm (Estradiol Patch)

Prescription only
Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.

The Estraderm (Estradiol Patch) needs to be replaced twice a week, and it may have fewer side effects than oral estrogen pills.

Relieves vaginal dryness due to menopause.

Estring (Estradiol Vaginal Ring) is a vaginal ring that may be less of a hassle than estrogen pills, gels, patches, or vaginal creams, but comes with the same side effects.

4.4/ 7 average rating with 56 reviewsforEstring
Upsides
  • The Estraderm (Estradiol Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen, like hot flashes and vaginal dryness.
  • The patch is good for people who don't want to take daily pills.
  • Can be worn while swimming, bathing, and showering.
  • By using a patch instead of a pill, there's a lower risk of side effects such as blood clots and stroke since lower amounts of estrogen are used in patches.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Good option for people who don't want to take oral pills.
  • Generally works well with fewer side effects.
  • Many women think Estring (Estradiol Vaginal Ring) is easy to insert and comfortable to use.
  • In a 12-week study, Estring (Estradiol Vaginal Ring) worked well to improve vaginal problems, reduced pain during urination, and sudden urges to urinate.
  • Estring (Estradiol Vaginal Ring) slowly releases estrogen over the 90 days the ring is in place, so you only have to remove and insert a new one every three months.
Downsides
  • Only comes in 2 strengths.
  • You need to replace the Estraderm (Estradiol Patch) twice a week, compared to other patches that are once a week.
  • Patch can fall off.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to use the Estraderm (Estradiol Patch) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can worsen other health conditions, like high cholesterol, asthma, diabetes, fluid retention, and migraines.
  • Can't be used in people with liver problems.
  • Estring (Estradiol Vaginal Ring) may not be the best estrogen product if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing it.
  • Increases your risk of endometrial (uterine cancer).
  • If you have your uterus, you might need to use Estring (Estradiol Vaginal Ring) with another hormone called progestin to lower your risk of uterine cancer.
  • Can be expensive since it's only available as a brand name product.
Used for
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Prevention of postmenopausal osteoporosis
  • Vaginal dryness and inflammation
Dosage forms
  • Patch
  • Vaginal ring
Price
No pricing information available
Lowest price near you
$429.27
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Reviews
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56 
63%
think this treatment is worth it
39%
think this treatment works well
18%
think this treatment is a hassle

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Side effects
10possible side effects
  • Breast pain
    28%
  • URTI
    17%
  • Abdominal pain
    16%
  • Headache
    13%
  • Pain
    11%
  • Edema
    10%
  • Back pain
    9%
  • Depression
    8%
  • Flatulence
    7%
  • Leukorrhea
    7%
See more detailed side effects
10possible side effects
  • Headache
    13%
  • Leukorrhea
    7%
  • Back Pain
    6%
  • Genital Moniliasis
    6%
  • Upper Respiratory Tract Infection
    5%
  • Vaginitis
    5%
  • Vaginal Discomfort/Pain
    5%
  • Arthritis
    4%
  • Insomnia
    4%
  • Abdominal Pain
    4%
See more detailed side effects
Risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 2 more risk factors

  • Increased risk of heart disease

    Smoking

    ...and 5 more risk factors

  • Harm to fetus

    Women of childbearing age

  • Pancreas swelling (pancreatitis)

    High levels of triglycerides

See more detailed risks and warnings
  • Endometrial cancer

    Using estrogen for more than one year

  • Breast cancer

    Personal or family history of breast cancer

    ...and 1 more risk factors

  • Increased risk of blood clots and stroke

    Personal or family history of blood clots

    ...and 2 more risk factors

  • Increased risk of heart disease

    Smoking

    ...and 5 more risk factors

  • Harm to fetus

    Women of childbearing age

  • Pancreas swelling (pancreatitis)

    High levels of triglycerides

See more detailed risks and warnings