Compare Estring vs. Estradiol Norethindrone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Relieves vaginal dryness due to menopause.

Estring (Estradiol Vaginal Ring) is a vaginal ring that may be less of a hassle than estrogen pills, gels, patches, or vaginal creams, but comes with the same side effects.

3.3/ 5 average rating with 56 reviewsforEstring
Relieves menopause symptoms and lowers your risk of osteoporosis.

Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.

Upsides
  • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Good option for people who don't want to take oral pills.
  • Generally works well with fewer side effects.
  • Many women think Estring (Estradiol Vaginal Ring) is easy to insert and comfortable to use.
  • In a 12-week study, Estring (Estradiol Vaginal Ring) worked well to improve vaginal problems, reduced pain during urination, and sudden urges to urinate.
  • Estring (Estradiol Vaginal Ring) slowly releases estrogen over the 90 days the ring is in place, so you only have to remove and insert a new one every three months.
  • Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Mimvey brand is less expensive than other estrogen/progestin combination medicines.
Downsides
  • Estring (Estradiol Vaginal Ring) may not be the best estrogen product if you have a narrow vagina or frequent vaginal infections.
  • The ring can fall out without you noticing it.
  • Increases your risk of endometrial (uterine cancer).
  • If you have your uterus, you might need to use Estring (Estradiol Vaginal Ring) with another hormone called progestin to lower your risk of uterine cancer.
  • Can be expensive since it's only available as a brand name product.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
Used for
  • Vaginal dryness and inflammation
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Prevention of postmenopausal osteoporosis
Dosage forms
  • Vaginal ring
  • Pill
Price
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Reviews
56 reviews so far
63%
saidit'sworth it
39%
saiditworked well
18%
saidit'sa big hassle

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Side effects
20possible side effects
  • Headache
    13%
  • Leukorrhea
    7%
  • Back Pain
    6%
  • Genital Moniliasis
    6%
  • Upper Respiratory Tract Infection
    5%
  • Vaginitis
    5%
  • Vaginal Discomfort/Pain
    5%
  • Arthritis
    4%
  • Insomnia
    4%
  • Abdominal Pain
    4%
  • Sinusitis
    4%
  • Vaginal Hemorrhage
    4%
  • Asymptomatic Genital Bacterial Growth
    4%
  • Arthralgia
    3%
  • Nausea
    3%
  • Flu-Like Symptoms
    3%
  • Skeletal Pain
    2%
  • Urinary Tract Infection
    2%
  • Hot Flushes
    2%
  • Family Stress
    2%
See more detailed side effects
15possible side effects
  • Breast Pain
    24%
  • Upper Respiratory Tract Infection
    18%
  • Headache
    16%
  • Sinusitis
    7%
  • Back Pain
    6%
  • Insomnia
    6%
  • Post-Menopausal Bleeding
    5%
  • Uterine Fibroid
    5%
  • Infection Viral
    4%
  • Moniliasis Genital
    4%
  • Injury Accidental
    4%
  • Nausea
    3%
  • Ovarian Cyst
    3%
  • Gastroenteritis
    2%
  • Other Events
    2%
See more detailed side effects
Risks and risk factors
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Duration of use
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Increased risk of heart disease
    • Smoking
    • Obesity
    • High blood pressure
    • High blood sugar
    • High cholesterol
    • Age 50 or older
  • Harm to fetus
    • Women of childbearing age
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
See more detailed risks and warnings
  • Endometrial cancer
    • Using estrogen for more than one year
  • Breast cancer
    • Personal or family history of breast cancer
    • Duration of use
  • Increased risk of blood clots and stroke
    • Personal or family history of blood clots
    • Obesity
    • Systemic lupus erythematosus (SLE)
  • Harm to fetus
    • Women of childbearing age
  • Pancreas swelling (pancreatitis)
    • High levels of triglycerides
  • Ovarian cancer
    • Family history of ovarian cancer
See more detailed risks and warnings