Compare Estring vs. Evamist

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Estring
(estradiol vaginal ring)

Evamist
(estradiol spray)

Relieves vaginal dryness due to menopause. Estring (Estradiol Vaginal Ring) is a vaginal ring that may be less of a hassle than estrogen pills, gels, patches, or vaginal creams, but comes with the same side effects.Relieves hot flashes due to menopause. Evamist (Estradiol Spray) is easy to use, absorbs well into your skin without needing to rub it in, and is a good option if you don’t want to use estrogen pills or patches.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.39Estring
Reviews for Estring (estradiol vaginal ring)
63%
of people (All ages) say Estring (estradiol vaginal ring) is worth it
39%
say it works well
18%
say it's a big hassle
Have you used Estring (estradiol vaginal ring)?
Worth itNot sureNot worth it

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Have you used Evamist (estradiol spray)?
Worth itNot sureNot worth it
Side effects
EstringEvamist
  • Headache 13%
  • Thick vaginal discharge 7%
  • Back pain 6%
  • Yeast infection 6%
  • Ear, nose, or throat infection 5%
  • Vaginitis 5%
  • Vaginal discomfort/pain 5%
  • Sinus inflammation 4%
  • Asymptomatic genital bacterial growth 4%
  • Abdominal pain 4%
More Estring side effects »
  • Headache 3%
  • Breast tenderness 4%
  • Nasopharyngitis (common cold) 3%
  • Nipple pain 2%
  • Back pain 1%
  • Nausea 1%
  • Arthralgia (joint pain) 3%
More Evamist side effects »
How it works
EstringEvamist
Estring (Estradiol Vaginal Ring) is a vaginal ring that replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps rebuild and maintain vaginal tissue, relieving symptoms of vaginal dryness, soreness, irritation, and painful sex.Evamist (Estradiol Spray) replaces estrogen hormones in your vagina that your body loses during menopause. Estrogen helps relieve symptoms of menopause, such as hot flashes, night sweats, and vaginal problems.
Type of medication
EstringEvamist
Prescription only
Prescription only
Available as
EstringEvamist
  • Vaginal ring
  • Spray
Used for
EstringEvamist
  • Vaginal Dryness And Inflammation
  • Hot Flashes And Night Sweats
Risk factors for serious side effects
EstringEvamist
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
  • High levels of triglycerides
Detailed Estring (estradiol vaginal ring) risks & warnings »
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Smoking
  • Obesity
  • High blood pressure
  • High blood sugar
  • High cholesterol
  • Age 50 or older
  • Women of childbearing age
    Detailed Evamist (estradiol spray) risks & warnings »
    Pregnancy

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Alcohol
    EstringEvamist
    No alcohol related info.
    • The spray is alcohol-based and flammable, so you shouldn't smoke while applying it.
    Weight
    EstringEvamist
    No weight related info.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    Upsides and benefits
    EstringEvamist
    • Estring (Estradiol Vaginal Ring) relieves vaginal dryness and irritation to make sex more enjoyable.
    • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
    • Good option for people who don't want to take oral pills.
    • Generally works well with fewer side effects.
    • Many women think Estring (Estradiol Vaginal Ring) is easy to insert and comfortable to use.
    • In a 12-week study, Estring (Estradiol Vaginal Ring) worked well to improve vaginal problems, reduced pain during urination, and sudden urges to urinate.
    • Estring (Estradiol Vaginal Ring) slowly releases estrogen over the 90 days the ring is in place, so you only have to remove and insert a new one every three months.
    • Evamist (Estradiol Spray) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness, low energy).
    • Dries faster than topical estrogen gels.
    • Good for people who don't want to take daily pills.
    • Fewer side effects than pills since lower amounts of estrogen are used in topical sprays.
    • Women in studies have seen the severity and number of hot flashes lower by half within 4 weeks of using Evamist (Estradiol Spray).
    • Very few women had skin irritation from the medicine.
    • Depending on your symptoms, your dose may change, but you can still use the same spray pump no matter what your dose is.
    • Can lower your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
    Downsides and risks
    EstringEvamist
    • Estring (Estradiol Vaginal Ring) may not be the best estrogen product if you have a narrow vagina or frequent vaginal infections.
    • The ring can fall out without you noticing it.
    • Increases your risk of endometrial (uterine cancer).
    • If you have your uterus, you might need to use Estring (Estradiol Vaginal Ring) with another hormone called progestin to lower your risk of uterine cancer.
    • Can be expensive since it's only available as a brand name product.
    • Increases your risk of endometrial and breast cancer.
    • If you have your uterus, you have to use Evamist (Estradiol Spray) with another hormone called progestin to lower your risk of uterine cancer.
    • Increases your risk of developing blood clots and stroke.
    • Can't be used in people with liver problems.
    • It's possible to expose other people to the estrogen before it's absorbed by your skin.
    • Can be expensive since it's only available as a brand name product.
    Tips from our pharmacists for people taking the medication
    EstringEvamist
    • Insert the ring as deeply as possible into your vagina. You shouldn't feel the ring once it's inserted.
    • The ring is good for 90 days in your vagina. If it falls out before the 90 days are up, just clean it with warm water and reinsert.
    • You don’t have to remove Estring (Estradiol Vaginal Ring) to treat a vaginal infection or have sex.
    • It can take up to 2 to 3 weeks to feel the full benefits.
    • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
    • Tell your doctor about any unusual vaginal bleeding.
    • Spray with the container upright and the cone flat against your skin on the inside of your forearm. If more than one spray is needed, always use a different area on your forearm.
    • Don't put it on your face, breasts, vagina, or irritated skin.
    • Don't rub it in. Let the spray dry for about 2 minutes before dressing, and don't get the application site wet for at least 1 hour.
    • Can cause nausea, dizziness, bloating, and breast tenderness.
    • Tell your doctor about any unusual vaginal bleeding.
    • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
    • The spray is alcohol-based and flammable, so you shouldn't smoke while applying it.
    Learn more
    More about EstringSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Estring (estradiol vaginal ring)?
    Worth itNot sureNot worth it
    More about EvamistSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Evamist (estradiol spray)?
    Worth itNot sureNot worth it