Compare fentanyl vs. Acetaminophen with codeine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Duragesic
(Fentanyl)

Tylenol #3
(Acetaminophen / Codeine)

Treats severe pain. Duragesic (Fentanyl) is an excellent pain reliever, but should only be used by people who've tried other opioid pain medications and still need more relief.Treats mild to moderate pain. Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.849056603773585fentanyl
Reviews for Duragesic (Fentanyl)
79%
of people say Duragesic (Fentanyl) is worth it
75%
say it works well
13%
say it's a big hassle
Reviews for Tylenol #3 (Acetaminophen / Codeine)
70%
9% vs. Duragesic (Fentanyl)
41%
34% vs. Duragesic (Fentanyl)
9%
+4% vs. Duragesic (Fentanyl)
Side effects
fentanylAcetaminophen with codeine
  • Feeling cold 4%
  • Feeling unwell 3%
  • Heart pounding or racing sensation 3%
  • Muscle spasms 2%
More fentanyl side effects »

The Acetaminophen with codeine FDA package insert doesn’t have numbers about how common side effects are.

More about Acetaminophen with codeine side effects »
How it works
fentanylAcetaminophen with codeine
Duragesic (Fentanyl) is an opioid (narcotic) medicine that works in the brain to lower pain perception.Tylenol #3 (Acetaminophen / Codeine) is a combination pain medicine. Codeine is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
fentanylAcetaminophen with codeine
Pain reliever
Opioid
Prescription only
Pain reliever
Acetaminophen (APAP)
Opioid
Prescription only
Available as
fentanylAcetaminophen with codeine
  • Patch
  • Patch extended release
  • Dissolving tablet
  • Mouth spray
  • Lozenge
  • Buccal tablet
  • Nasal spray
  • Pill
  • Liquid
Used for (click to learn more)
fentanylAcetaminophen with codeine
Risk factors for serious side effects
fentanylAcetaminophen with codeine
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
  • Children age 18 and younger
  • Long-term use during pregnancy
  • Taking more than the prescribed dose
  • Long-term use
  • History of drug abuse
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Age 65 years or older
Detailed Duragesic (Fentanyl) risks & warnings »
Coming soon.
Pregnancy category
fentanylAcetaminophen with codeine
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
  • Never drink alcohol when using Duragesic (Fentanyl).
  • Avoid alcohol.
Food
No specific food-related info.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • Often causes drowsiness and constipation. If using it long-term, use a stool softener.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Can make you dizzy or drowsy.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
fentanylAcetaminophen with codeine
  • It's used for people who have tried other opioid medications, but still need stronger pain relief.
  • Duragesic (Fentanyl) is stronger than morphine, works quickly, and doesn't cause as many stomach problems.
  • It's available in many dosage forms, including a patch, injection, film, nasal spray, and lollipop.
  • The Duragesic (Fentanyl) patch provides long-term pain relief and lowers the number of times you need to take pain medications each day.
  • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relieve for mild to moderate pain to improve quality of life.
  • Good for as-needed pain and control.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides and risks
fentanylAcetaminophen with codeine
  • Duragesic (Fentanyl) isn't for everyone. It's a really strong pain medication and taking too much can be deadly.
  • It doesn't provide quick pain relief.
  • Often causes drowsiness and constipation. If using it long-term, use a stool softener.
  • Like all opioids, don't use when pregnant, since the baby can become dependent on it and have withdrawal symptoms after birth.
  • Shouldn't be used for people with breathing problems (like asthma and COPD), a slow heart rate, or in the elderly.
  • If using the patch, you won't be able to get the medicine out of your body quickly in case of an overdose.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Tips from our pharmacists for people taking the medication
fentanylAcetaminophen with codeine
  • Duragesic (Fentanyl) should only be used for people whose pain is not controlled by other opioid medications for at least one week.
  • For pain, the patch takes 12 hours to start working and all other forms start working in 30 minutes or less.
  • If using the patch, keep it away from heat sources like heating pads, or else it'll cause the medication to be unsafely released into your skin.
  • Never stop taking Duragesic (Fentanyl) suddenly or else you'll have withdrawal effects. To stop taking it, you'll need to lower your dose slowly.
  • Never drink alcohol when using Duragesic (Fentanyl).
  • Just one dose can be harmful or fatal to children, so store and dispose of this medication in a way that children can't get to it.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Starts working in 30 minutes.
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Can make you dizzy or drowsy.
  • Avoid activities need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
  • Don't take more than instructed to prevent liver damage.
  • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
  • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
Learn more
More about fentanylSide effectsReviews & ratingsAlternativesFDA package insert
More about Acetaminophen with codeineSide effectsReviews & ratingsAlternativesFDA package insert