Compare Fentanyl vs. Opana

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Duragesic
(Fentanyl)

Opana
(Oxymorphone)

Treats severe pain. Duragesic (Fentanyl) is an excellent pain reliever, but should only be used by people who've tried other opioid pain medications and still need more relief.Coming soon.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.83Fentanyl
Reviews for Duragesic (Fentanyl)
79%
of people (All ages) say Duragesic (Fentanyl) is worth it
70%
say it works well
14%
say it's a big hassle
Have you used Duragesic (Fentanyl)?
Worth itNot sureNot worth it

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Have you used Opana (Oxymorphone)?
Worth itNot sureNot worth it
Side effects
FentanylOpana

The Fentanyl FDA package insert doesn’t have numbers about how common side effects are.

More about Fentanyl side effects »

We haven’t found good data for Opana side effects.

FDA side effect reports for Opana »
How it works
FentanylOpana
Duragesic (Fentanyl) is an opioid (narcotic) medicine that works in the brain to lower pain perception.Coming soon.
Type of medication
FentanylOpana
Pain reliever
Opioid
Prescription only
Coming soon.
Available as
FentanylOpana
  • Patch
  • Patch extended release
  • Dissolving tablet
  • Mouth spray
  • Lozenge
  • Buccal tablet
  • Nasal spray
  • Pill
Used for (click to learn more)
FentanylOpana
  • Anesthesia; Adjunct Anxiety
Risk factors for serious side effects
FentanylOpana
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
FentanylOpana
  • Never drink alcohol when using Duragesic (Fentanyl).
No alcohol related info.
Pain
FentanylOpana
  • Duragesic (Fentanyl) isn't for everyone. It's a really strong pain medication and taking too much can be deadly.
  • For pain, the patch takes 12 hours to start working and all other forms start working in 30 minutes or less.
No pain related info.
Sleep
FentanylOpana
  • Often causes drowsiness and constipation. If using it long-term, use a stool softener.
No sleep related info.
Upsides and benefits
FentanylOpana
  • It's used for people who have tried other opioid medications, but still need stronger pain relief.
  • Duragesic (Fentanyl) is stronger than morphine, works quickly, and doesn't cause as many stomach problems.
  • It's available in many dosage forms, including a patch, injection, film, nasal spray, and lollipop.
  • The Duragesic (Fentanyl) patch provides long-term pain relief and lowers the number of times you need to take pain medications each day.
Coming soon
Downsides and risks
FentanylOpana
  • Duragesic (Fentanyl) isn't for everyone. It's a really strong pain medication and taking too much can be deadly.
  • It doesn't provide quick pain relief.
  • Often causes drowsiness and constipation. If using it long-term, use a stool softener.
  • Like all opioids, don't use when pregnant, since the baby can become dependent on it and have withdrawal symptoms after birth.
  • Shouldn't be used for people with breathing problems (like asthma and COPD), a slow heart rate, or in the elderly.
  • If using the patch, you won't be able to get the medicine out of your body quickly in case of an overdose.
Coming soon
Tips from our pharmacists for people taking the medication
FentanylOpana
  • Duragesic (Fentanyl) should only be used for people whose pain is not controlled by other opioid medications for at least one week.
  • For pain, the patch takes 12 hours to start working and all other forms start working in 30 minutes or less.
  • If using the patch, keep it away from heat sources like heating pads, or else it'll cause the medication to be unsafely released into your skin.
  • Never stop taking Duragesic (Fentanyl) suddenly or else you'll have withdrawal effects. To stop taking it, you'll need to lower your dose slowly.
  • Never drink alcohol when using Duragesic (Fentanyl).
  • Just one dose can be harmful or fatal to children, so store and dispose of this medication in a way that children can't get to it.
Coming soon
Learn more
More about FentanylSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Duragesic (Fentanyl)?
Worth itNot sureNot worth it
More about OpanaSide effectsReviews & ratingsFDA package insert
Have you used Opana (Oxymorphone)?
Worth itNot sureNot worth it