Compare fentanyl vs. Opana

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Treats severe pain. Duragesic (Fentanyl) is an excellent pain reliever, but should only be used by people who've tried other opioid pain medications and still need more relief.Coming soon.
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Side effects
  • Feeling cold 4%
  • Feeling unwell 3%
  • Heart pounding or racing sensation 3%
  • Muscle spasms 2%
More fentanyl side effects »

We haven’t found good data for Opana side effects.

FDA side effect reports for Opana »
How it works
Duragesic (Fentanyl) is an opioid (narcotic) medicine that works in the brain to lower pain perception.Coming soon.
Type of medication
Pain reliever
Prescription only
Coming soon.
Available as
  • Patch
  • Patch extended release
  • Dissolving tablet
  • Mouth spray
  • Lozenge
  • Buccal tablet
  • Nasal spray
  • Pill
Used for (click to learn more)
  • Anesthesia; Adjunct Anxiety
Risk factors for serious side effects
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
  • Children age 18 and younger
  • Long-term use during pregnancy
  • Taking more than the prescribed dose
  • Long-term use
  • History of drug abuse
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Age 65 years or older
Detailed Duragesic (Fentanyl) risks & warnings »
Coming soon.
Pregnancy category
  • Never drink alcohol when using Duragesic (Fentanyl).
No specific alcohol-related info.
No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
No specific sex-related info.No specific sex-related info.
  • Often causes drowsiness and constipation. If using it long-term, use a stool softener.
No specific sleep-related info.
No specific weight-related info.No specific weight-related info.
Upsides and benefits
  • It's used for people who have tried other opioid medications, but still need stronger pain relief.
  • Duragesic (Fentanyl) is stronger than morphine, works quickly, and doesn't cause as many stomach problems.
  • It's available in many dosage forms, including a patch, injection, film, nasal spray, and lollipop.
  • The Duragesic (Fentanyl) patch provides long-term pain relief and lowers the number of times you need to take pain medications each day.
Coming soon.
Downsides and risks
  • Duragesic (Fentanyl) isn't for everyone. It's a really strong pain medication and taking too much can be deadly.
  • It doesn't provide quick pain relief.
  • Often causes drowsiness and constipation. If using it long-term, use a stool softener.
  • Like all opioids, don't use when pregnant, since the baby can become dependent on it and have withdrawal symptoms after birth.
  • Shouldn't be used for people with breathing problems (like asthma and COPD), a slow heart rate, or in the elderly.
  • If using the patch, you won't be able to get the medicine out of your body quickly in case of an overdose.
Coming soon.
Tips from our pharmacists for people taking the medication
  • Duragesic (Fentanyl) should only be used for people whose pain is not controlled by other opioid medications for at least one week.
  • For pain, the patch takes 12 hours to start working and all other forms start working in 30 minutes or less.
  • If using the patch, keep it away from heat sources like heating pads, or else it'll cause the medication to be unsafely released into your skin.
  • Never stop taking Duragesic (Fentanyl) suddenly or else you'll have withdrawal effects. To stop taking it, you'll need to lower your dose slowly.
  • Never drink alcohol when using Duragesic (Fentanyl).
  • Just one dose can be harmful or fatal to children, so store and dispose of this medication in a way that children can't get to it.
Coming soon.
Learn more
More about fentanylSide effectsReviews & ratingsAlternativesFDA package insert
More about OpanaSide effectsReviews & ratingsFDA package insert