Compare fentanyl vs. Opana

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Treats severe pain.

Duragesic (fentanyl) is an excellent pain reliever, but should only be used by people who've tried other opioid pain medications and still need more relief.

4.2/ 5 average rating with 84 reviewsforfentanyl
No information currently available
Upsides
  • Duragesic (fentanyl) is stronger than morphine, works quickly, and doesn't cause as many stomach problems.
  • It's available in many dosage forms, including a patch, injection, film, nasal spray, and lollipop.
  • The Duragesic (fentanyl) patch provides long-term pain relief and lowers the number of times you need to take pain medications each day.
No information currently available
Downsides
  • Duragesic (fentanyl) isn't for everyone. It's a really strong pain medication and taking too much can be deadly.
  • The patch doesn't provide quick pain relief.
  • Often causes drowsiness and constipation. If taking long-term, use a stool softener.
  • Shouldn't be used by people with breathing problems (like asthma and COPD), a slow heart rate, or are elderly.
No information currently available
Used for
  • Anesthesia; Adjunct Anxiety
  • Due to dyspnea associated with pulmonary edema caused by acute left ventricular dysfunction Obstetric pain Pain
  • Acute (Moderate to Severe) Pain
  • Chronic (Severe)
  • In patients requiring daily long-term around-the-clock opioid analgesic Premedication for anesthetic procedure - Surgical procedure
Dosage forms
  • Patch
  • Dissolving tablet
  • Mouth spray
  • Lozenge
  • Buccal tablet
  • Nasal spray
  • Pill
Price
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Reviews
84 reviews so far
79%
saidit'sworth it
70%
saiditworked well
14%
saidit'sa big hassle

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Side effects
34possible side effects
  • Vomiting
    34%
  • Nausea
    24%
  • Dizziness
    17%
  • Drowsiness
    17%
  • Headache
    16%
  • Constipation
    13%
  • Diarrhea
    13%
  • Itchy skin
    13%
  • Weakness
    9%
  • Abdominal pain
    9%
  • Difficulty sleeping
    6%
  • Rash
    6%
  • Swelling in the limbs
    5%
  • Confusion
    4%
  • Difficulty breathing
    4%
  • Upper abdominal pain
    4%
  • Loss of appetite
    4%
  • Anxiety
    4%
  • Tremor
    3%
  • Hypersensitivity
    3%
  • Urinary retention
    3%
  • Sweating
    3%
  • Accidental injury
    2%
  • Abnormal gait
    2%
  • Dry mouth
    2%
  • Nervousness
    2%
  • Dilation of blood vessels
    2%
  • Abnormal vision
    2%
  • Burning/pricking sensation
    2%
  • Confusional state
    2%
  • Fatigue
    2%
  • Muscle spasms
    2%
  • Depression
    2%
  • Hallucination
    2%
See more detailed side effects
The Opana (Oxymorphone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Slowed breathing (respiratory depression)
    • Taking other medicines that interact with Duragesic (fentanyl)
    • Age 65 or greater
    • Taking benzodiazepines, other opioids, and/or alcohol
    • Asthma or COPD
  • Death from overdose
    • Children age 18 and younger
  • Death in newborn babies from opioid withdrawal
    • Long-term use of Duragesic (fentanyl) during pregnancy
  • Tolerance, dependence, and addiction
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
  • Driving impairment
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
  • Medication errors
See more detailed risks and warnings
No information currently available