Compare Fiorinal vs. Imitrex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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(Butalbital / Aspirin / Caffeine)


Coming soon.Treats migraine headaches. Imitrex (Sumatriptan) is an excellent choice for acute migraine relief, but you might need another medication to prevent headaches.
How it works
Coming soon.Imitrex (Sumatriptan) is a triptan medication that treats migraine headaches. It releases serotonin, which lowers the inflammation that causes headaches.
Type of medication
Coming soon.
Prescription only
Available as
  • Pill
  • Pill
  • Injection
  • Nasal spray
Used for (click to learn more)
  • Tension-type headache
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Reviews & ratings
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Reviews for Imitrex (Sumatriptan)
23% vs. Fiorinal (Butalbital / Aspirin / Caffeine)
27% vs. Fiorinal (Butalbital / Aspirin / Caffeine)
15% vs. Fiorinal (Butalbital / Aspirin / Caffeine)
Side effects

We haven’t found good data for Fiorinal side effects.

FDA side effect reports for Fiorinal »
  • Pain and other pressure sensations 4%
  • Paresthesia (all types) 3%
  • Atypical sensations 2%
  • Chest - pain/tightness/pressure and/or heaviness 1%
  • Pain - location specified 1%
  • Sensation warm/cold 1%
  • Other - pressure/tightness/ heaviness 1%
More Imitrex side effects »
Risk factors for serious side effects
Coming soon.
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
  • Smoking
  • History of heart problems
  • High blood pressure
  • High cholesterol
  • Diabetes
  • Being overweight or obese
  • Smoking
    • Patients taking SSRIs and SNRIs
    • History of high blood pressure
    • History of seizures
    Detailed Imitrex (Sumatriptan) risks & warnings »
    Pregnancy category
    No specific alcohol-related info.No specific alcohol-related info.
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    No specific sex-related info.No specific sex-related info.
    No specific sleep-related info.No specific sleep-related info.
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    Coming soon.
    • Comes in several forms. Ask your doctor if you should use the pill, nasal spray, patch, or injection.
    • A combination of forms can be used if symptoms do not improve.
    • The nasal spray and injectable forms work very quickly.
    • It's generally safe to use if you are pregnant.
    • Comes in a generic form, so it can be pretty cheap.
    Downsides and risks
    Coming soon.
    • The oral and nasal versions of Imitrex (Sumatriptan) have an unpleasant after-taste.
    • Does not prevent migraine headaches; it only treats them once they start.
    • Must wait 1 hour before using second injection.
    • Can cause rebound (more) headaches if Imitrex (Sumatriptan) is used too often.
    • Need to have your blood pressure checked often, especially if you're pregnant.
    Tips from our pharmacists for people taking the medication
    Coming soon.
    • Take it as soon as your headache starts.
    • If you use the nasal spray, be sure to blow your nose before using it.
    • If you use the patch, put it on a dry area free of scars, tattoos, or other cuts and scrapes. Be sure to press the button to activate it.
    • If you use the injection, you can use a second injection if you still have a headache after an hour. If you have symptoms 2 hours after the injection, switch to the pill version.
    • Imitrex (Sumatriptan) can make you drowsy, so avoid activities that need you to be fully alert until you know how it affects you.
    • Lie down in a dark room after taking Imitrex (Sumatriptan) to help ease the pain.
    Learn more
    More about FiorinalSide effectsReviews & ratingsFDA package insert
    More about ImitrexSide effectsReviews & ratingsAlternativesFDA package insert