Compare Flexeril vs. baclofen

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Flexeril
(cyclobenzaprine)

Lioresal
(baclofen)

Relaxes your muscles. Flexeril (Cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.Relaxes your muscles. Lioresal (baclofen) is a first choice treatment for muscle spasticity caused by multiple sclerosis or spinal cord injuries, but it's not recommended for other types of muscle spasms.
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Coupons for Flexeril
Best available price for 90 (10mg) tablets of cyclobenzaprine
Coupons for baclofen
Best available price for 90 (10mg) tablets of baclofen
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.69Flexeril
Reviews for Flexeril (cyclobenzaprine)
66%
of people (All ages) say Flexeril (cyclobenzaprine) is worth it
37%
say it works well
14%
say it's a big hassle
1064 reviews
Have you used Flexeril (cyclobenzaprine)?
Worth itNot sureNot worth it
Reviews for Lioresal (baclofen)
61%
-5% worse vs. Flexeril (cyclobenzaprine)
55%
+18% better vs. Flexeril (cyclobenzaprine)
15%
-1% worse vs. Flexeril (cyclobenzaprine)
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it
Side effects
Flexerilbaclofen
  • Dry mouth 4%
  • Dizziness 1%
  • Fatigue 1%
  • Nausea 2%
  • Drowsiness 100%
  • Headache nos 17%
  • Dry throat 8%
  • Acne nos 6%
  • Disturbance in attention 6%
More Flexeril side effects »
  • Drowsiness 27%
More baclofen side effects »
How it works
Flexerilbaclofen
Flexeril (Cyclobenzaprine) is a muscle relaxer. It works in the brain to help calm down muscle spasms without interfering with normal muscle function.Lioresal (baclofen) is a gamma-aminobutryic acid (GABA) agonist. It's not clear how it works, but GABA is believed to help calm down nerves. Muscle spasms are thought to be started by overactive nerves.
Type of medication
Flexerilbaclofen
Prescription only
Prescription only
Available as
Flexerilbaclofen
  • Pill
  • Extended release
  • Pill
Used for
Flexerilbaclofen
Risk factors for serious side effects
Flexerilbaclofen
  • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
  • Taking other medications for your mood
  • Alcohol or drug use
  • Age over 65
  • Taking tramadol
Detailed Flexeril (cyclobenzaprine) risks & warnings »
  • Stopping Lioresal (baclofen) too quickly
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Higher dose
Detailed Lioresal (baclofen) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
Flexerilbaclofen
  • Don't drink alcohol while on this medication.
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
Pain
Flexerilbaclofen
  • Can relieve pain associated with muscle spasms.
No pain related info.
Sleep
Flexerilbaclofen
  • Taking Flexeril (Cyclobenzaprine) may make you feel dizzy or sleepy for the first few days, especially if you drink a lot of alcohol or take recreational drugs. Your body should adjust to this, however, avoid driving or other activities requiring concentration until you know how your body responds to the medication. Talk to your doctor or pharmacist if these symptoms bother you.
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
Upsides and benefits
Flexerilbaclofen
  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women.
  • A better option for seniors compared to other muscle relaxants since it has fewer side effects than other similar medicines.
  • Lioresal (baclofen) is available as a generic and is a relatively inexpensive medication.
Downsides and risks
Flexerilbaclofen
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with recent heart issues (like rhythm problems, heart failure, or heart attack).
  • Except for specific muscle spasms caused by brain injury or multiple sclerosis, Lioresal (baclofen) is not a recommended medicine.
  • If you've been taking Lioresal (baclofen) regularly for a long time, you'll need to get off of it slowly.
  • Lioresal (baclofen) can make you sleepy.
  • If you've had a stroke, Lioresal (baclofen) may not work as well, and you're more likely to experience side effects.
Tips from our pharmacists for people taking the medication
Flexerilbaclofen
  • Can cause dizziness, fatigue, and sleepiness.
  • Take the medication at the same time each day.
  • Not to be used for long-term treatment.
  • Don't drink alcohol while on this medication.
  • Lioresal (baclofen) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Don't stop taking Lioresal (baclofen) suddenly without talking to your doctor if you've been on it for a long time. It can be dangerous. Your doctor will help you get off it slowly over time.
  • Avoid drinking alcohol while on Lioresal (baclofen) because it can make you very sleepy or slow your breathing down.
Learn more
More about FlexerilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Flexeril (cyclobenzaprine)?
Worth itNot sureNot worth it
More about baclofenSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lioresal (baclofen)?
Worth itNot sureNot worth it