Compare Flexeril vs. Norflex

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Flexeril
(Cyclobenzaprine)

Norflex
(Orphenadrine)

Relaxes your muscles. Flexeril (Cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.Coming soon.
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Reviews & ratings
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4.682646212847555Flexeril
Reviews for Flexeril (Cyclobenzaprine)
66%
of people (All ages) say Flexeril (Cyclobenzaprine) is worth it
37%
say it works well
14%
say it's a big hassle
1043 reviews
Have you used Flexeril (Cyclobenzaprine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Norflex (Orphenadrine)?
Worth itNot sureNot worth it
Side effects
FlexerilNorflex
  • Indigestion 3%
  • Fatigue 1%
More Flexeril side effects »

We haven’t found good data for Norflex side effects.

FDA side effect reports for Norflex »
How it works
FlexerilNorflex
Flexeril (Cyclobenzaprine) is a muscle relaxer. It works in the brain to help calm down muscle spasms without interfering with normal muscle function.Coming soon.
Type of medication
FlexerilNorflex
Muscle relaxerPrescription only
Coming soon.
Available as
FlexerilNorflex
  • Pill
  • Extended release
  • Extended release
Used for (click to learn more)
FlexerilNorflex
  • Musculoskeletal pain
Risk factors for serious side effects
FlexerilNorflex
  • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
  • Taking other medications for your mood
  • Alcohol or drug use
  • Age over 65
  • Taking tramadol
Detailed Flexeril (Cyclobenzaprine) risks & warnings »
Coming soon.
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
FlexerilNorflex
  • Don't drink alcohol while on this medication.
No alcohol related info.
Pain
FlexerilNorflex
  • Can relieve pain associated with muscle spasms.
No pain related info.
Sleep
FlexerilNorflex
  • Taking Flexeril (Cyclobenzaprine) may make you feel dizzy or sleepy for the first few days, especially if you drink a lot of alcohol or take recreational drugs. Your body should adjust to this, however, avoid driving or other activities requiring concentration until you know how your body responds to the medication. Talk to your doctor or pharmacist if these symptoms bother you.
No sleep related info.
Upsides and benefits
FlexerilNorflex
  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women.
Coming soon
Downsides and risks
FlexerilNorflex
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with recent heart issues (like rhythm problems, heart failure, or heart attack).
Coming soon
Tips from our pharmacists for people taking the medication
FlexerilNorflex
  • Can cause dizziness, fatigue, and sleepiness.
  • Take the medication at the same time each day.
  • Not to be used for long-term treatment.
  • Don't drink alcohol while on this medication.
Coming soon
Learn more
More about FlexerilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Flexeril (Cyclobenzaprine)?
Worth itNot sureNot worth it
More about NorflexSide effectsReviews & ratingsFDA package insert
Have you used Norflex (Orphenadrine)?
Worth itNot sureNot worth it