Compare Flexeril vs. Skelaxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Flexeril (cyclobenzaprine)

Prescription only
Relaxes your muscles.

Flexeril (cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.

4.7/ 7 average rating with 1064 reviewsforFlexeril
Relaxes your muscles.

Skelaxin (metaxalone) is used for muscle spasms and musculoskeletal pain with mixed results.

Upsides
  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women, but talk to your doctor about it first.
  • Can be used for muscle spasms and muscle pain if other medications have not worked.
  • Available as generic.
  • Slightly less sedation and side effects compared to other muscle relaxants.
Downsides
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with heart conditions (like rhythm problems, heart failure, or recent heart attack).
  • Can make you have dry mouth.
  • Not effective for muscle spasms caused by brain or spinal injuries.
  • Effects don't last that long. You need to take Skelaxin (metaxalone) up to 3-4 times daily.
  • Several studies showed mixed results when Skelaxin (metaxalone) was compared with a sugar pill for treatment of muscle spasms and musculoskeletal pain.
  • Can make you very drowsy or sleepy
  • Even though a generic is available, it is still fairly expensive.
Used for
  • Musculoskeletal pain
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
Lowest price near you
$8.1
Find instant savings
Lowest price near you
$46.22
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
1064 
66%
think this treatment is worth it
37%
think this treatment works well
14%
think this treatment is a hassle

Have you used Flexeril (cyclobenzaprine)?

Leave a review
Not enough review data.Leave a review
Side effects
4possible side effects
  • Dry mouth
    6%
  • Dizziness
    3%
  • Fatigue
    3%
  • Nausea
    3%
See more detailed side effects
The Skelaxin (metaxalone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Serotonin syndrome

    Taking monoamine oxidase inhibitors (MAOI)

    ...and 1 more risk factors

  • Dizziness and sleepiness

    Alcohol or drug use

    ...and 1 more risk factors

  • Heart attack or stroke

    Recent heart attack

    ...and 2 more risk factors

  • Dehydration

    Older than 65 years

    ...and 1 more risk factors

  • Overactive Thyroid

    Overactive thyroid

See more detailed risks and warnings
  • Sleepiness and dizziness

    Taking other medications that also cause sleepiness

    ...and 2 more risk factors

  • Serotonin syndrome

    Taking antidepressants

    ...and 1 more risk factors

  • Liver damage

    History of liver disease

  • Liver or Kidney problems

    History of liver disease

    ...and 1 more risk factors

See more detailed risks and warnings