Compare Flexeril vs. Skelaxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Coming soon.

Flexeril
(Cyclobenzaprine)

Skelaxin
(Metaxalone)

Relaxes your muscles. Flexeril (Cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.Coming soon.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.69Flexeril
Reviews for Flexeril (Cyclobenzaprine)
66%
of people (All ages) say Flexeril (Cyclobenzaprine) is worth it
37%
say it works well
14%
say it's a big hassle
1064 reviews
Have you used Flexeril (Cyclobenzaprine)?
Worth itNot sureNot worth it

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Have you used Skelaxin (Metaxalone)?
Worth itNot sureNot worth it
Side effects
FlexerilSkelaxin
  • Indigestion 3%
  • Fatigue 1%
More Flexeril side effects »

We haven’t found good data for Skelaxin side effects.

FDA side effect reports for Skelaxin »
How it works
FlexerilSkelaxin
Flexeril (Cyclobenzaprine) is a muscle relaxer. It works in the brain to help calm down muscle spasms without interfering with normal muscle function.Coming soon.
Type of medication
FlexerilSkelaxin
Muscle relaxerPrescription only
Coming soon.
Available as
FlexerilSkelaxin
  • Pill
  • Extended release
  • Pill
Used for (click to learn more)
FlexerilSkelaxin
  • Musculoskeletal pain
Risk factors for serious side effects
FlexerilSkelaxin
  • Taking monoamine oxidase inhibitors (MAOI) 14 days before starting
  • Taking other medications for your mood
  • Alcohol or drug use
  • Age over 65
  • Taking tramadol
Detailed risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
FlexerilSkelaxin
  • Don't drink alcohol while on this medication.
No alcohol related info.
Pain
FlexerilSkelaxin
  • Can relieve pain associated with muscle spasms.
No pain related info.
Sleep
FlexerilSkelaxin
  • Taking Flexeril (Cyclobenzaprine) may make you feel dizzy or sleepy for the first few days, especially if you drink a lot of alcohol or take recreational drugs. Your body should adjust to this, however, avoid driving or other activities requiring concentration until you know how your body responds to the medication. Talk to your doctor or pharmacist if these symptoms bother you.
No sleep related info.
Upsides and benefits
FlexerilSkelaxin
  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women.
Coming soon
Downsides and risks
FlexerilSkelaxin
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with recent heart issues (like rhythm problems, heart failure, or heart attack).
Coming soon
Tips from our pharmacists for people taking the medication
FlexerilSkelaxin
  • Can cause dizziness, fatigue, and sleepiness.
  • Take the medication at the same time each day.
  • Not to be used for long-term treatment.
  • Don't drink alcohol while on this medication.
Coming soon
Learn more
More about FlexerilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Flexeril (Cyclobenzaprine)?
Worth itNot sureNot worth it
More about SkelaxinSide effectsReviews & ratingsFDA package insert
Have you used Skelaxin (Metaxalone)?
Worth itNot sureNot worth it