Compare Flexeril vs. Skelaxin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Flexeril
(cyclobenzaprine)

Skelaxin
(metaxalone)

Relaxes your muscles. Flexeril (cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.Coming soon.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.69Flexeril
Reviews for Flexeril
66%
of people (All ages) say Flexeril is worth it
37%
say it works well
14%
say it's a big hassle
1064 reviews
Have you used Flexeril (cyclobenzaprine)?
Worth itNot sureNot worth it

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Have you used Skelaxin (metaxalone)?
Worth itNot sureNot worth it
Side effects
FlexerilSkelaxin
  • Dry mouth 4%
  • Dizziness 1%
  • Fatigue 1%
  • Nausea 2%
  • Sleepiness 100%
  • Headache 17%
  • Dry throat 8%
  • Acne 6%
  • Disturbance in attention 6%
  • Drowsiness 18%
More Flexeril side effects »

We haven’t found good data for Skelaxin side effects.

FDA side effect reports for Skelaxin »
How it works
FlexerilSkelaxin
Flexeril (cyclobenzaprine) is a muscle relaxer. It works in the brain to help calm down muscle spasms without interfering with normal muscle function.Coming soon.
Type of medication
FlexerilSkelaxin
Prescription only
Available as
FlexerilSkelaxin
  • Pill
  • Liquid
  • Pill
Used for
FlexerilSkelaxin
  • Musculoskeletal Pain
Risk factors for serious side effects
FlexerilSkelaxin
  • Taking monoamine oxidase inhibitors (MAOI)
  • Taking other medications for your mood
  • Alcohol or drug use
  • Age over 65 years
  • Recent heart attack
Detailed Flexeril (cyclobenzaprine) risks & warnings »
    Coming soon.
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Pain
    FlexerilSkelaxin
    • Can relieve pain associated with muscle spasms.
    No pain related info.
    Sleep
    FlexerilSkelaxin
    • Taking Flexeril (cyclobenzaprine) may make you feel dizzy or sleepy for the first few days. Avoid driving or other activities requiring concentration until you know how your body responds to the medication. Talk to your doctor or pharmacist if these symptoms bother you.
    • Flexeril (cyclobenzaprine) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
    No sleep related info.
    Upsides and benefits
    FlexerilSkelaxin
    • Can relieve pain associated with muscle spasms.
    • Available as a generic medication.
    • Can be used by pregnant women, but talk to your doctor about it first.
    Coming soon
    Downsides and risks
    FlexerilSkelaxin
    • Can cause dizziness and sleepiness.
    • Not meant for long-term therapy.
    • Not recommended in elderly patients, people with glaucoma, or in people with heart conditions (like rhythm problems, heart failure, or recent heart attack).
    • Can make you have dry mouth.
    • Not effective for muscle spasms caused by brain or spinal injuries.
    Coming soon
    Tips from our pharmacists for people taking the medication
    FlexerilSkelaxin
    • Flexeril (cyclobenzaprine) can make you feel very tired or sleepy. Don't drive or do anything that requires concentration until you know how it affects you.
    • Flexeril (cyclobenzaprine) is not meant to be used long-term. It should be used for only 2 to 3 weeks maximum.
    • Flexeril (cyclobenzaprine) can cause dry mouth.
    • Take it roughly at the same time every day.
    • If you are using the capsules, you may swallow it whole or sprinkle contents on a tablespoon of applesauce and swallow immediately without chewing.
    Coming soon
    Learn more
    More about FlexerilSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Flexeril (cyclobenzaprine)?
    Worth itNot sureNot worth it
    More about SkelaxinSide effectsReviews & ratingsFDA package insert
    Have you used Skelaxin (metaxalone)?
    Worth itNot sureNot worth it