Compare Flexeril vs. Zanaflex

Flexeril (Cyclobenzaprine) and Zanaflex (Tizanidine) are muscle relaxers that help calm down muscle spasms. Flexeril may make you feel dizzy or sleepy for the first few days, and shouldn’t be used long-term. Zanaflex isn’t a first-choice muscle relaxing medication because other drugs better and have fewer side effects.

Flexeril (cyclobenzaprine)

Prescription only

Zanaflex (tizanidine)

Prescription only
Relaxes your muscles.

Flexeril (cyclobenzaprine) is widely used to treat muscle spasms and is available as a generic, but it shouldn't be used long-term.

4.7/ 7 average rating with 1064 reviewsforFlexeril
Relaxes your muscles.

Zanaflex (tizanidine) isn't a first-choice treatment for muscle spasticity. Try other options before using this.

6.0/ 7 average rating with 26 reviewsforZanaflex
Upsides
  • Can relieve pain associated with muscle spasms.
  • Available as a generic medication.
  • Can be used by pregnant women, but talk to your doctor about it first.
  • Relieves muscle spasticity.
  • Available as a generic.
  • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
Downsides
  • Can cause dizziness and sleepiness.
  • Not meant for long-term therapy.
  • Not recommended in elderly patients, people with glaucoma, or in people with heart conditions (like rhythm problems, heart failure, or recent heart attack).
  • Can make you have dry mouth.
  • Not effective for muscle spasms caused by brain or spinal injuries.
  • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
  • Takes over an hour to kick in and only lasts 3 to 6 hours.
  • Zanaflex (tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
  • Need to be consistent every day in taking this with or without food.
  • Elderly individuals have more side effects when taking Zanaflex (tizanidine).
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
Lowest price near you
$8.1
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$21.55
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Reviews
1064 
66%
think this treatment is worth it
37%
think this treatment works well
14%
think this treatment is a hassle

Have you used Flexeril (cyclobenzaprine)?

Leave a review
26 
81%
think this treatment is worth it
73%
think this treatment works well
19%
think this treatment is a hassle

Have you used Zanaflex (tizanidine)?

Leave a review
Side effects
4possible side effects
  • Dry mouth
    6%
  • Dizziness
    3%
  • Fatigue
    3%
  • Nausea
    3%
See more detailed side effects
10possible side effects
  • Dry mouth
    49%
  • Sleepiness
    48%
  • Weakness
    41%
  • Dizziness
    16%
  • Urinary tract infection
    10%
  • General infection
    6%
  • Liver test abnormality
    6%
  • Constipation
    4%
  • Vomiting
    3%
  • Speech disorder
    3%
See more detailed side effects
Risks and warnings
  • Serotonin syndrome

    Taking monoamine oxidase inhibitors (MAOI)

    ...and 1 more risk factors

  • Dizziness and sleepiness

    Alcohol or drug use

    ...and 1 more risk factors

  • Heart attack or stroke

    Recent heart attack

    ...and 2 more risk factors

  • Dehydration

    Older than 65 years

    ...and 1 more risk factors

  • Overactive Thyroid

    Overactive thyroid

See more detailed risks and warnings
  • Liver damage

    Taking maximum doses of Zanaflex (tizanidine)

  • Dizziness and low blood pressure

    Age 65 years or older

    ...and 1 more risk factors

  • Sleepiness and driving impairment

    Taking other medications that also cause sleepiness

    ...and 3 more risk factors

  • Withdrawal side effects

    Stopping Zanaflex (tizanidine) suddenly

See more detailed risks and warnings