Compare Flonase vs. Allegra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Flonase
(Fluticasone)

Allegra
(Fexofenadine)

Relieves allergy symptoms. Flonase (Fluticasone) is a good first-choice medicine for treating a runny or stuffy nose caused by allergies, and it's cheaper than some alternatives.Treats allergy symptoms. Allegra (Fexofenadine) relieves allergy symptoms without making you feel drowsy.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.048808172531214Flonase
Reviews for Flonase (Fluticasone)
72%
of people say Flonase (Fluticasone) is worth it
43%
say it works well
7%
say it's a big hassle
Reviews for Allegra (Fexofenadine)
77%
+5% vs. Flonase (Fluticasone)
59%
+16% vs. Flonase (Fluticasone)
0%
+7% vs. Flonase (Fluticasone)
Side effects
FlonaseAllegra
  • Asthma symptoms 4%
  • Nausea/vomiting 3%
  • Nosebleed 2%
  • Headache 1%
  • Cough 1%
  • Sore throat 1%
More Flonase side effects »
  • Vomiting 3%
  • Headache 3%
  • Cough 3%
  • Back pain 2%
  • Ear, nose, or throat infection 2%
  • Diarrhea 1%
  • Fever 1%
  • Runny nose 1%
  • Dizziness 1%
  • Stomach discomfort 1%
More Allegra side effects »
How it works
FlonaseAllegra
Flonase (Fluticasone) is a nasal steroid. It works directly in your nose to reduce swelling and inflammation caused by allergies.Allegra (Fexofenadine) is an antihistamine. It blocks histamine, a chemical that causes congestion, itching, and other allergic reactions.
Type of medication
FlonaseAllegra
Anti-inflammatory
Corticosteroid
Prescription or OTC
Antihistamine
2nd generation
Prescription or OTC
Available as
FlonaseAllegra
  • Nasal spray
  • Pill
  • Dissolving tablet
  • Liquid
Used for (click to learn more)
FlonaseAllegra
Risk factors for serious side effects
FlonaseAllegra
  • Switching from oral or injectable steroids to inhaled, especially if used long term
  • Using other inhaled steroids with Flonase (Fluticasone)
    • Long-term use
    • Taking more than recommended dose
    • Switching from oral or injectable steroids to inhaled, especially if used long term
    • Using other inhaled steroids with Flonase (Fluticasone)
    • Long-term use
    • Exposure to immunizable diseases (chickenpox and measles)
    • Exposure to tuberculosis
    • Surgery or trauma to the nose or sinuses
    • Long-term use
    Detailed Flonase (Fluticasone) risks & warnings »
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • History of phenylketonuria (PKU)
    Detailed Allegra (Fexofenadine) risks & warnings »
    Pregnancy category
    FlonaseAllegra
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.
    • The dose needs to be adjusted for people with kidney problems.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.
    • Won't make you feel drowsy like some antihistamine medicines.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    FlonaseAllegra
    • First-choice medication for treating runny and stuffy noses caused by allergies. It works by reducing inflammation in the nose.
    • Because it's used directly where the inflammation is happening, it has fewer side effects than oral steroids do and has a lower chance of causing withdrawal symptoms once the medication is stopped.
    • Can be used as needed to help control symptoms in people age 13 years or older.
    • Available as a generic medication.
    • Relieves allergy symptoms, like sneezing, runny nose, and itching.
    • Approved to be used in kids and adults age 6 months and older.
    • Won't make you feel drowsy like some antihistamine medicines.
    • Available over-the-counter without a prescription.
    • Comes in many forms, such as a tablet, liquid, or quick-dissolving tablet.
    • It's okay to take with most other medications since it has very few interactions.
    Downsides and risks
    FlonaseAllegra
    • Flonase (Fluticasone) doesn't have a counter on it, so it can be hard to remember how many sprays are left (each bottle has 120 sprays).
    • Needs to be primed (pressed/pumped until a fine spray appears) up to six times prior to using it for the first time, or if you haven't used it in 2 weeks.
    • Since the medicine in Flonase (Fluticasone) is a steroid, it can slow down your healing process if you've hurt your nose or had nose surgery.
    • For some people, the effects Allegra (Fexofenadine) has on allergies will wear off over time.
    • May not work as well as the first-generation antihistamines, like diphenhydramine (Benadryl).
    • The dose needs to be adjusted for people with kidney problems.
    Tips from our pharmacists for people taking the medication
    FlonaseAllegra
    • It can take several days for Flonase (Fluticasone) to start working fully.
    • Don't take more of it than was prescribed for you.
    • Blow your nose before using Flonase (Fluticasone).
    • Can cause thrush (a fungal infection) inside the nose and throat.
    • Can also cause a headache, sore throat, or nosebleeds.
    • Starts working in 1 to 2 hours depending on what dosage form you're taking.
    • Works best when taken regularly, even before symptoms are expected to appear.
    • Can make you feel dizzy or sleepy, so you can take it at bedtime.
    • Follow age-specific dosing and don't take more than recommended.
    • If symptoms get worse or you need to use it for more than a few weeks, talk with your doctor.
    Learn more
    More about FlonaseSide effectsReviews & ratingsAlternativesFDA package insert
    More about AllegraSide effectsReviews & ratingsAlternativesFDA package insert