Compare Flonase vs. Nasonex

Flonase (Fluticasone) and Nasonex (Mometasone) are steroids that help relieve allergy symptoms, and are both available as nasal spray. Flonase is a good first-choice medicine for treating a runny or stuffy nose caused by allergies, and it's cheaper than some alternatives. Nasonex is also a good first-choice treatment but can take 1 to 2 weeks to start working fully.

Flonase
(fluticasone)

Nasonex
(mometasone)

Relieves allergy symptoms. Flonase (Fluticasone) is a good first-choice medicine for treating a runny or stuffy nose caused by allergies, and it's cheaper than some alternatives.Relieves allergy symptoms. Nasonex (Mometasone) is a good first-choice treatment for stuffy and runny noses caused by allergies.
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Coupons for Flonase
Best available price for 1 (16g of 50mcg) nasal spray of flonase
Coupons for Nasonex
Best available price for 1 (17g of 50mcg) nasal spray of nasonex
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.05Flonase
Reviews for Flonase
72%
of people (All ages) say Flonase is worth it
43%
say it works well
7%
say it's a big hassle
890 reviews
Have you used Flonase (fluticasone)?
Worth itNot sureNot worth it
Reviews for Nasonex
68%
+4% better vs. Flonase
39%
+4% better vs. Flonase
8%
+1% better vs. Flonase
675 reviews
Have you used Nasonex (mometasone)?
Worth itNot sureNot worth it
Side effects
FlonaseNasonex
  • Asthma symptoms 4%
  • Nosebleed 1%
  • Nausea/vomiting 3%
  • Cough 1%
  • Blood in mucus 2%
  • Bronchitis 2%
  • Abdominal pain 2%
More Flonase side effects »
  • Headache 4%
  • Viral infection 3%
  • Sore throat 2%
  • Nosebleed 5%
  • Coughing 1%
  • Ear, nose, or throat infection 4%
  • Menstrual cramps 2%
  • Musculoskeletal pain 2%
  • Sinus inflammation 2%
  • Joint pain 4%
More Nasonex side effects »
How it works
FlonaseNasonex
Flonase (Fluticasone) is a nasal steroid. It works directly in your nose to reduce swelling and inflammation caused by allergies.Nasonex (Mometasone) is a topical steroid. It works directly where it's applied to help reduce swelling and inflammation in your nose.
Type of medication
FlonaseNasonex
Prescription or OTCPrescription only
Available as
FlonaseNasonex
  • Nasal spray
  • Nasal spray
Used for
FlonaseNasonex
Risk factors for serious side effects
FlonaseNasonex
  • Switching from oral or injectable steroids to inhaled, especially if used long term
  • Using other inhaled steroids with Flonase (Fluticasone)
  • Long-term use
  • Taking more than recommended dose
Detailed Flonase (fluticasone) risks & warnings »
  • Long-term use
  • Surgery or trauma to the nose or sinuses
  • Exposure to immunizable diseases (chickenpox and measles)
Detailed Nasonex (mometasone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Pain
FlonaseNasonex
  • Long-term use of Flonase (Fluticasone) can increase your chances of getting thrush in the nose and throat. Your doctor will check your nose and throat if you have to be on this medication for a long time. Also, tell your doctor if you notice pain in the nose and throat with redness and white patches.
  • Long-term use of Nasonex (Mometasone) can increase your chances of getting thrush in the nose and throat. Your doctor will check your nose and throat if you have to be on this medication for a long time. Also, tell your doctor if you notice pain in the nose and throat with redness and white patches.
Upsides and benefits
FlonaseNasonex
  • First-choice medication for treating runny and stuffy noses caused by allergies. It works by reducing inflammation in the nose.
  • Because it's used directly where the inflammation is happening, it has fewer side effects than oral steroids do and has a lower chance of causing withdrawal symptoms once the medication is stopped.
  • Can be used as needed to help control symptoms in people age 13 years or older.
  • Available as a generic medication.
  • First-choice medication for treating runny and stuffy noses caused by allergies. It works by reducing inflammation in the nose.
  • Because it's used directly where the inflammation is happening, it has fewer side effects than oral steroids do and has a lower chance of causing withdrawal symptoms once the medication is stopped.
  • Can be used as needed to help control symptoms in people age 13 years or older.
  • Available as a generic, which is cheaper.
Downsides and risks
FlonaseNasonex
  • Flonase (Fluticasone) doesn't have a counter on it, so it can be hard to remember how many sprays are left (each bottle has 120 sprays).
  • Needs to be primed (pressed/pumped until a fine spray appears) up to six times prior to using it for the first time, or if you haven't used it in 2 weeks.
  • Since the medicine in Flonase (Fluticasone) is a steroid, it can slow down your healing process if you've hurt your nose or had nose surgery.
  • Needs to be primed 10 times before it can be used, or re-primed if not used for more than 2 weeks.
  • Doesn't have a counter on it, so it can be hard to remember how many sprays are left (each bottle has 120 sprays).
  • Since the medicine in Nasonex (Mometasone) is a steroid, it can slow down your healing process if you've hurt your nose or had nose surgery.
Tips from our pharmacists for people taking the medication
FlonaseNasonex
  • It can take several days for Flonase (Fluticasone) to start working fully.
  • Don't take more of it than was prescribed for you.
  • Blow your nose before using Flonase (Fluticasone).
  • Can cause thrush (a fungal infection) inside the nose and throat.
  • Can also cause a headache, sore throat, or nosebleeds.
  • Use Nasonex (Mometasone) once a day, following age-specific recommendations on how many sprays to use. Don't take more than prescribed.
  • Blow your nose before using.
  • Can cause thrush (a fungal infection) inside your nose and throat. Can also cause nosebleeds, a sore throat, and headaches.
  • Needs to be used regularly during allergy season for it to work. It can take 1 to 2 weeks for the medicine to start working fully.
  • Check with your doctor or pharmacist on how to use the nasal spray the right way.
  • Shake well before using it. Before the first use, prime the bottle by spraying it until you see a fine mist.
Learn more
More about FlonaseSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Flonase (fluticasone)?
Worth itNot sureNot worth it
More about NasonexSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Nasonex (mometasone)?
Worth itNot sureNot worth it