Compare Flonase vs. Nyquil Cold and Flu

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Flonase
(Fluticasone)

Nyquil Cold And Flu
(Acetaminophen / Dextromethorphan / Doxylamine)

Relieves allergy symptoms. Flonase (Fluticasone) is a good first-choice medicine for treating a runny or stuffy nose caused by allergies, and it's cheaper than some alternatives.Relieves cold and flu symptoms, and helps you sleep. Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a useful combination medicine that relieves cold and flu symptoms and will help you sleep. Make sure you really need all of its ingredients.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.048808172531214Flonase
Reviews for Flonase (Fluticasone)
72%
of people say Flonase (Fluticasone) is worth it
43%
say it works well
7%
say it's a big hassle
Reviews for Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine)
83%
+11% vs. Flonase (Fluticasone)
42%
1% vs. Flonase (Fluticasone)
6%
+1% vs. Flonase (Fluticasone)
Side effects
FlonaseNyquil Cold and Flu
  • Asthma symptoms 4%
  • Nausea/vomiting 3%
  • Nosebleed 2%
  • Headache 1%
  • Cough 1%
  • Sore throat 1%
More Flonase side effects »

We haven’t found good data for Nyquil Cold and Flu side effects.

FDA side effect reports for Nyquil Cold and Flu »
How it works
FlonaseNyquil Cold and Flu
Flonase (Fluticasone) is a nasal steroid. It works directly in your nose to reduce swelling and inflammation caused by allergies.Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that treats cold and flu symptoms. Acetaminophen relieves pain and reduces fever. Dextromethorphan is a cough suppressant. Doxylamine is an antihistamine that relieves a runny nose and makes you very sleepy.
Type of medication
FlonaseNyquil Cold and Flu
Anti-inflammatory
Corticosteroid
Prescription or OTC
Pain reliever
APAP
Cough suppressantAntihistamine
Ethanolamine derivative
Over-the-counter
Available as
FlonaseNyquil Cold and Flu
  • Nasal spray
  • Pill
  • Liquid
Used for (click to learn more)
FlonaseNyquil Cold and Flu
Risk factors for serious side effects
FlonaseNyquil Cold and Flu
  • Switching from oral or injectable steroids to inhaled, especially if used long term
  • Using other inhaled steroids with Flonase (Fluticasone)
    • Long-term use
    • Taking more than recommended dose
    • Switching from oral or injectable steroids to inhaled, especially if used long term
    • Using other inhaled steroids with Flonase (Fluticasone)
    • Long-term use
    • Exposure to immunizable diseases (chickenpox and measles)
    • Exposure to tuberculosis
    • Surgery or trauma to the nose or sinuses
    • Long-term use
    Detailed Flonase (Fluticasone) risks & warnings »
    • Drinking more than 2 alcoholic beverages a day
    • Taking with other Tylenol-containing medicines
    • History of liver disease
    • Using other medications that affect serotonin
    • Taking with alcohol
    • Taking with other medicines that make you less alert
    • Age 65 years or older
    • Glaucoma
    • Benign prostatic hypertrophy (BPH)
    Detailed Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) risks & warnings »
    Pregnancy category
    FlonaseNyquil Cold and Flu
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.
    • Avoid using alcohol and other drugs that make you drowsy.
    Food
    No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.
    • The antihistamine (doxylamine) will help you sleep.
    • Avoid using alcohol and other drugs that make you drowsy.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    FlonaseNyquil Cold and Flu
    • First-choice medication for treating runny and stuffy noses caused by allergies. It works by reducing inflammation in the nose.
    • Because it's used directly where the inflammation is happening, it has fewer side effects than oral steroids do and has a lower chance of causing withdrawal symptoms once the medication is stopped.
    • Can be used as needed to help control symptoms in people age 13 years or older.
    • Available as a generic medication.
    • Nyquil Cold And Flu (Acetaminophen / Dextromethorphan / Doxylamine) is a combination medicine that relieves multiple cold symptoms. It's good to use if you have watery eyes, a cough, fever, and pain.
    • The cough medicine (dextromethorphan) works well and has very few side effects.
    • The pain reliever (acetaminophen) is easier on your stomach and has fewer drug interactions than other pain medications like aspirin or ibuprofen.
    • The antihistamine (doxylamine) will help you sleep.
    Downsides and risks
    FlonaseNyquil Cold and Flu
    • Flonase (Fluticasone) doesn't have a counter on it, so it can be hard to remember how many sprays are left (each bottle has 120 sprays).
    • Needs to be primed (pressed/pumped until a fine spray appears) up to six times prior to using it for the first time, or if you haven't used it in 2 weeks.
    • Since the medicine in Flonase (Fluticasone) is a steroid, it can slow down your healing process if you've hurt your nose or had nose surgery.
    • If you don't really need all of the medications in this combination, you're taking extra medicine and might have extra side effects for no reason.
    • You shouldn't use it if you have high blood pressure.
    • To avoid hurting your liver, you have to keep track of the total amount of acetaminophen (APAP) you're taking since it's a very common ingredient in pain and cold/flu combination medicines.
    Tips from our pharmacists for people taking the medication
    FlonaseNyquil Cold and Flu
    • It can take several days for Flonase (Fluticasone) to start working fully.
    • Don't take more of it than was prescribed for you.
    • Blow your nose before using Flonase (Fluticasone).
    • Can cause thrush (a fungal infection) inside the nose and throat.
    • Can also cause a headache, sore throat, or nosebleeds.
    • Doxylamine (the antihistamine ingredient) can make you tired, so take it close to bedtime.
    • Follow age-specific dosing instructions on how much to take. Don't take more than recommended on the package.
    • Contains acetaminophen, also known as Tylenol or APAP. Taking too much can cause liver failure and death. Don't take more than what's recommended on the package or with other Tylenol-containing products.
    • Avoid using alcohol and other drugs that make you drowsy.
    • Let your doctor know if your symptoms don't improve in a few days, or if you have a really bad sore throat with a fever, headache, nausea, or vomiting.
    Learn more
    More about FlonaseSide effectsReviews & ratingsAlternativesFDA package insert
    More about Nyquil Cold and FluSide effectsReviews & ratingsAlternativesFDA package insert