Compare Fluoxymesterone vs. Depo-Testosterone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Androxy
(Fluoxymesterone)

Depo-Testosterone
(Testosterone Cypionate Injection)

Treats low testosterone. While Androxy (Fluoxymesterone) is available for treating low testosterone, other treatments are better first choices.Treats low testosterone. This testosterone injection only has to be given once or twice a month and you can do it at home, but someone has to help you inject.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
3.742574257425743Fluoxymesterone
Reviews for Androxy (Fluoxymesterone)
47%
of people say Androxy (Fluoxymesterone) is worth it
23%
say it works well
27%
say it's a big hassle
Reviews for Depo-Testosterone (Testosterone Cypionate Injection)
48%
+1% vs. Androxy (Fluoxymesterone)
31%
+8% vs. Androxy (Fluoxymesterone)
17%
+10% vs. Androxy (Fluoxymesterone)
Side effects
FluoxymesteroneDepo-Testosterone

The Fluoxymesterone FDA package insert doesn’t have numbers about how common side effects are.

More about Fluoxymesterone side effects »

The Depo-Testosterone FDA package insert doesn’t have numbers about how common side effects are.

More about Depo-Testosterone side effects »
How it works
FluoxymesteroneDepo-Testosterone
Androxy (Fluoxymesterone) works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on. Also, it can slow the spread of certain kinds of breast cancer.The testosterone injection works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.
Type of medication
FluoxymesteroneDepo-Testosterone
Hormone replacementPrescription only
Hormone replacement
Testosterone
Prescription only
Available as
FluoxymesteroneDepo-Testosterone
  • Pill
  • Injection
Used for (click to learn more)
FluoxymesteroneDepo-Testosterone
  • Low testosterone
  • Low testosterone
Risk factors for serious side effects
FluoxymesteroneDepo-Testosterone
  • Diabetes
  • Male
  • Male
  • Enlarged prostate (benign prostatic hypertrophy)
  • Taking high doses of Androxy (Fluoxymesterone)
  • Heart, liver or kidney disease
  • Female
  • Breast cancer
  • Inability to move
      Detailed Androxy (Fluoxymesterone) risks & warnings »
      • Male
      • Male
      • Enlarged prostate (benign prostatic hypertrophy)
      • Taking high doses of Depo-Testosterone (Testosterone Cypionate Injection)
      • Heart, liver or kidney disease
      • Inability to move
      • Cancer
          • Diabetes
          • On blood thinners
            Detailed Depo-Testosterone (Testosterone Cypionate Injection) risks & warnings »
            Pregnancy category
            FluoxymesteroneDepo-Testosterone
            XFDA pregnancy category (Unsafe)

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            See the FDA package insert
            XFDA pregnancy category (Unsafe)

            Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

            See the FDA package insert
            Alcohol
            No specific alcohol-related info.No specific alcohol-related info.
            Food
            No specific food-related info.No specific food-related info.
            Kidneys and liver
            • There have been reports of people on Androxy (Fluoxymesterone) who have developed high levels of calcium in the blood, which can be bad for the kidneys. This has happened if you have breast cancer or if you are unable to move around. If you notice a metallic taste in your mouth, muscle or joint pain or a bad headache, talk to your doctor, since they may have to stop the medication.
            • There have been reports of people on Depo-Testosterone (Testosterone Cypionate Injection) who have developed high levels of calcium in the blood, which can be bad for the kidneys. This can happen if you are unable to move around or have cancer. If you notice a metallic taste in your mouth, muscle or joint pain or a bad headache, talk to your doctor, since they may have to stop the medication.
            Sex
            • Can cause increased acne and changes in sex drive.
            • If you're a man taking Androxy (Fluoxymesterone), you can see changes in your sex drive, including overstimulation and prolonged frequent erections. Talk to your doctor if this happens, since they might have to change the dose.
            • Can cause increased acne and changes in sex drive.
            • If you're a man taking Depo-Testosterone (Testosterone Cypionate Injection), you can see changes in your sex drive, including overstimulation and prolonged frequent erections. Talk to your doctor if this happens, since they might have to change the dose.
            Sleep
            No specific sleep-related info.No specific sleep-related info.
            Weight
            • If you're taking Androxy (Fluoxymesterone), and you notice swelling in your legs, or a sudden increase in your weight, talk to your doctor. This can be a serious side effect involving your heart.
            • If you're taking Depo-Testosterone (Testosterone Cypionate Injection), and you notice swelling in your legs, or a sudden increase in your weight, talk to your doctor. This can be a serious side effect involving your heart.
            Upsides and benefits
            FluoxymesteroneDepo-Testosterone
            • Available as an oral tablet.
            • A first-choice treatment for low testosterone in men and delayed puberty in boys.
            • Available in generic.
            • Only has to be given once every 2 to 4 weeks.
            • The shot can be done at home.
            Downsides and risks
            FluoxymesteroneDepo-Testosterone
            • Not considered a first-choice treatment for low testosterone, and not recommended for treating breast cancers that respond to testosterone.
            • Available only as brand name, so it can be expensive.
            • Only available as a shot.
            • Has to be given by someone else since it has to be injected into your buttocks.
            Tips from our pharmacists for people taking the medication
            FluoxymesteroneDepo-Testosterone
            • Can cause nausea, vomiting, and headache.
            • Don't double up if you miss a dose.
            • Can cause increased acne and changes in sex drive.
            • Keep this medication locked up and away from children since it's a controlled substance.
            • Your doctor will show you how to inject this correctly.
            • Can cause nausea, vomiting and headache.
            • Can cause increased acne and changes in sex drive.
            • Keep this medication locked up and away from children since it's a controlled substance.
            Learn more
            More about FluoxymesteroneSide effectsReviews & ratingsAlternativesFDA package insert
            More about Depo-TestosteroneSide effectsReviews & ratingsAlternativesFDA package insert