Compare fluphenazine vs. Haldol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prolixin
(fluphenazine)

Haldol
(haloperidol)

Treats schizophrenia and psychosis. Prolixin (fluphenazine) can stabilize your mood. It is used to find the right dose for you before moving to a long-acting injection.Helps control your thoughts and calms agitation. Haldol (Haloperidol) is okay for treating psychosis and agitation. It's less likely to cause weight gain than other antipsychotics, but it's more likely to cause other bad side effects.
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Coupons for fluphenazine
Best available price for 60 (5mg) tablets of fluphenazine
Coupons for Haldol
Best available price for 30 (5mg) tablets of haloperidol
Reviews & ratings
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Have you used Prolixin (fluphenazine)?
Worth itNot sureNot worth it
Reviews for Haldol
38%
-38% worse vs. fluphenazine
42%
-42% worse vs. fluphenazine
34%
+34% better vs. fluphenazine
Have you used Haldol (haloperidol)?
Worth itNot sureNot worth it
Side effects
fluphenazineHaldol

The fluphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about fluphenazine side effects »

The Haldol FDA package insert doesn’t have numbers about how common side effects are.

More about Haldol side effects »
How it works
fluphenazineHaldol
Prolixin (fluphenazine) is a derivative of phenothiazine. It regulates dopamine levels in your brain to control psychotic episodes or schizophrenia.Haldol (Haloperidol) is a traditional antipsychotic. Researchers don't know exactly how it works, but it seems to change dopamine activity in your brain, which affects thoughts and mood.
Type of medication
fluphenazineHaldol
Prescription onlyPrescription only
Available as
fluphenazineHaldol
  • Pill
  • Liquid
  • Injection
  • Pill
  • Liquid
  • Injection
Used for
fluphenazineHaldol
Risk factors for serious side effects
fluphenazineHaldol
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
Detailed Prolixin (fluphenazine) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Haldol (haloperidol) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
fluphenazineHaldol
  • Don't combine with alcohol or narcotics since it can stop your breathing.
No alcohol related info.
Food
fluphenazineHaldol
No food related info.
  • Haldol (Haloperidol) can increase your blood sugar and cholesterol. However, Haldol (Haloperidol) is less likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
Sleep
fluphenazineHaldol
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
  • It can cause dizziness, drowsiness, and can lower your blood pressure.
Weight
fluphenazineHaldol
No weight related info.
  • Haldol (Haloperidol) can cause you to gain weight. However, Haldol (Haloperidol) is less likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
Upsides and benefits
fluphenazineHaldol
  • Good at stabilizing your mood.
  • Available in several oral and injectable forms, including a long-acting injection that is taken less frequently.
  • Effective at relieving psychotic symptoms and agitation.
  • Works just as well as other antipsychotic medicines.
  • Less likely to cause weight gain and problems with cholesterol and blood sugar than most other antipsychotics.
Downsides and risks
fluphenazineHaldol
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can make it difficult for you to control your movements if you've been on Prolixin (fluphenazine) for a while.
  • It's an older medicine and has a lot more side effects than newer antipsychotics.
  • Compared to other antipsychotics, it causes more hormone problems that can cause nipples to leak fluid, and sudden, dangerous abnormal heart rhythms.
  • Has a higher risk of extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements. One of these symptoms (called tardive dyskinesia) is permanent and more likely if you take this medicine for many years.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
Tips from our pharmacists for people taking the medication
fluphenazineHaldol
  • Can make you more sensitive to the sun. Wear sunscreen or protective clothing while outside.
  • Can make it difficult for you to start and stop your movements. Talk to your doctor right away if this happens.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
  • Don't stop taking Prolixin (fluphenazine) suddenly. It can be dangerous.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Mix the concentrated form with at least 1/4 cup of fluids. Don't mix with caffeine, tea, or apple juice since it affects the absorption of Prolixin (fluphenazine).
  • It'll take 4 to 6 weeks to see the medication's full effects on your thoughts.
  • It can cause dizziness, drowsiness, and can lower your blood pressure.
  • For the first week, avoid activities like driving that require you to be alert.
  • Immediately tell your doctor if you can't control your muscle movements or if you have a fever or excess sweating.
  • Don't use in elderly people who have dementia.
  • The oral liquid concentrate can be mixed with water or juice before taking it.
Learn more
More about fluphenazineSide effectsAlternativesFDA package insert
Have you used Prolixin (fluphenazine)?
Worth itNot sureNot worth it
More about HaldolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Haldol (haloperidol)?
Worth itNot sureNot worth it