Compare fluphenazine vs. loxapine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prolixin
(fluphenazine)

Loxitane
(loxapine)

Treats schizophrenia and psychosis. Prolixin (fluphenazine) can stabilize your mood. It is used to find the right dose for you before moving to a long-acting injection.Treats schizophrenia. Loxitane (loxapine) is not recommended as a first choice medicine for treatment of schizophrenia, but it can be good if other medicines haven't worked because of bad side effects.
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Coupons for fluphenazine
Best available price for 60 (5mg) tablets of fluphenazine
Coupons for loxapine
Best available price for 60 (10mg) capsules of loxapine
Reviews & ratings
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Have you used Prolixin (fluphenazine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Loxitane (loxapine)?
Worth itNot sureNot worth it
Side effects
fluphenazineloxapine

The fluphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about fluphenazine side effects »

The loxapine FDA package insert doesn’t have numbers about how common side effects are.

More about loxapine side effects »
How it works
fluphenazineloxapine
Prolixin (fluphenazine) is a derivative of phenothiazine. It regulates dopamine levels in your brain to control psychotic episodes or schizophrenia.Loxitane (loxapine) is a typical antipsychotic. It works in the brain to calm down parts of the brain that might be responsible for aggressive behavior.
Type of medication
fluphenazineloxapine
Prescription onlyPrescription only
Available as
fluphenazineloxapine
  • Pill
  • Liquid
  • Injection
  • Pill
Used for
fluphenazineloxapine
Risk factors for serious side effects
fluphenazineloxapine
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
Detailed Prolixin (fluphenazine) risks & warnings »
  • People age 65 and older with dementia and psychosis
  • Taking antipsychotic medications
  • History of seizures
Detailed Loxitane (loxapine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
fluphenazineloxapine
  • Don't combine with alcohol or narcotics since it can stop your breathing.
  • Don't drink alcohol or take narcotics while taking Loxitane (loxapine) since you can have problems breathing.
Food
fluphenazineloxapine
No food related info.
  • Take Loxitane (loxapine) with food to avoid stomach upset.
Sleep
fluphenazineloxapine
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
No sleep related info.
Upsides and benefits
fluphenazineloxapine
  • Good at stabilizing your mood.
  • Available in several oral and injectable forms, including a long-acting injection that is taken less frequently.
  • Loxitane (loxapine) can be used to control schizophrenia if other medicines haven't worked because you don't like their side effects.
  • Loxitane (loxapine) is available as a generic.
Downsides and risks
fluphenazineloxapine
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can make it difficult for you to control your movements if you've been on Prolixin (fluphenazine) for a while.
  • Loxitane (loxapine) is not recommended as a first choice for treating schizophrenia because it's more likely to cause trouble with controlling movements.
  • Loxitane (loxapine) can stop vomiting, so it can be difficult to tell if someone's overdosed on drugs.
  • Loxitane (loxapine) can raise heart rate and lower blood pressure.
Tips from our pharmacists for people taking the medication
fluphenazineloxapine
  • Can make you more sensitive to the sun. Wear sunscreen or protective clothing while outside.
  • Can make it difficult for you to start and stop your movements. Talk to your doctor right away if this happens.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
  • Don't stop taking Prolixin (fluphenazine) suddenly. It can be dangerous.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Mix the concentrated form with at least 1/4 cup of fluids. Don't mix with caffeine, tea, or apple juice since it affects the absorption of Prolixin (fluphenazine).
  • Take Loxitane (loxapine) with food to avoid stomach upset.
  • Don't drive or do anything requiring concentration until you know how Loxitane (loxapine) affects you since it can make you sleepy.
  • Don't drink alcohol or take narcotics while taking Loxitane (loxapine) since you can have problems breathing.
  • Be very careful getting up if you've been sitting or lying down for a while as Loxitane (loxapine) can cause changes in your blood pressure, which might make you more likely to faint or fall.
Learn more
More about fluphenazineSide effectsAlternativesFDA package insert
Have you used Prolixin (fluphenazine)?
Worth itNot sureNot worth it
More about loxapineSide effectsAlternativesFDA package insert
Have you used Loxitane (loxapine)?
Worth itNot sureNot worth it