Compare fluphenazine vs. thioridazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prolixin (fluphenazine)

Prescription only

Mellaril (thioridazine)

Prescription only
Treats schizophrenia and psychosis.

Prolixin (fluphenazine) can stabilize your mood. It is used to find the right dose for you before moving to a long-acting injection.

Treats schizophrenia.

Taking Mellaril (thioridazine) is one of many options to treat schizophrenia if other medicines haven't worked, but there are some side effects which can be dangerous.

Upsides
  • Good at stabilizing your mood.
  • Available in several oral and injectable forms, including a long-acting injection that is taken less frequently.
  • Available in generic.
  • Compared to other similar medicines, Mellaril (thioridazine) is less likely to cause problems controlling your movements.
Downsides
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can make it difficult for you to control your movements if you've been on Prolixin (fluphenazine) for a while.
  • Mellaril (thioridazine) is only recommended for schizophrenia if other medicines haven't worked because the side effects can be very dangerous.
  • You have to take Mellaril (thioridazine) numerous times a day which can make it hard to remember.
  • Mellaril (thioridazine) can interfere with your heartbeat, so your doctor might have you do annual tests with your heart to make sure it's healthy.
Used for
Dosage forms
  • Pill
  • Liquid
  • Injection
  • Pill
Price
Lowest price near you
$15.99
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Lowest price near you
$27.76
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Side effects
The Prolixin (fluphenazine) FDA package insert doesn’t have numbers about how common side effects are.
The Mellaril (thioridazine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Increased risk of death

    People over 65 with dementia and psychosis

  • Neuroleptic malignant syndrome

    Taking antipsychotic medications

See more detailed risks and warnings
  • Problems with the heartbeat

    History of heartbeat problems

    ...and 2 more risk factors

  • Increased risk of death in elderly people with dementia

    People older than 65 years with dementia and psychosis

  • Difficulty controlling movements

    Long-term use of Mellaril (thioridazine)

  • Neuroleptic malignant syndrome

    Taking antipsychotic medications

  • Sleepiness and risk of falls

    Drinking alcohol or taking narcotics

  • Decreased white blood cells

    History of low white blood cells

See more detailed risks and warnings