Compare fluphenazine vs. thioridazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Prolixin
(fluphenazine)

Mellaril
(thioridazine)

Treats schizophrenia and psychosis. Prolixin (fluphenazine) can stabilize your mood. It is used to find the right dose for you before moving to a long-acting injection.Treats schizophrenia. Taking Mellaril (thioridazine) is one of many options to treat schizophrenia if other medicines haven't worked, but there are some side effects which can be dangerous.
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Best available price for 60 (5mg) tablets of fluphenazine
Reviews & ratings
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Have you used Prolixin (fluphenazine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Mellaril (thioridazine)?
Worth itNot sureNot worth it
Side effects
fluphenazinethioridazine

The fluphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about fluphenazine side effects »

The thioridazine FDA package insert doesn’t have numbers about how common side effects are.

More about thioridazine side effects »
How it works
fluphenazinethioridazine
Prolixin (fluphenazine) is a derivative of phenothiazine. It regulates dopamine levels in your brain to control psychotic episodes or schizophrenia.Mellaril (thioridazine) is a typical antipsychotic that lowers levels of dopamine in the brain. In schizophrenia, it's believed the brain produces too much dopamine.
Type of medication
fluphenazinethioridazine
Prescription onlyPrescription only
Available as
fluphenazinethioridazine
  • Pill
  • Liquid
  • Injection
  • Pill
Used for
fluphenazinethioridazine
Risk factors for serious side effects
fluphenazinethioridazine
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
Detailed Prolixin (fluphenazine) risks & warnings »
  • History of heartbeat problems
  • Taking medicines for depression
  • Taking beta blockers
  • People older than 65 years with dementia and psychosis
  • Long-term use of Mellaril (thioridazine)
Detailed Mellaril (thioridazine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
fluphenazinethioridazine
  • Don't combine with alcohol or narcotics since it can stop your breathing.
  • Don't drink alcohol while taking Mellaril (thioridazine).
Food
fluphenazinethioridazine
No food related info.
  • You can take Mellaril (thioridazine) with or without food. Take it with food if you get an upset stomach.
Sleep
fluphenazinethioridazine
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Mellaril (thioridazine) can make you feel sleepy the first few days that you take it, and you might be more likely to fall and hurt yourself. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Mellaril (thioridazine) affects you. Be very careful getting up if you've been sitting or lying down for a while, and brace yourself and sit down if you do feel dizzy.
Upsides and benefits
fluphenazinethioridazine
  • Good at stabilizing your mood.
  • Available in several oral and injectable forms, including a long-acting injection that is taken less frequently.
  • Available in generic.
  • Compared to other similar medicines, Mellaril (thioridazine) is less likely to cause problems controlling your movements.
Downsides and risks
fluphenazinethioridazine
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can make it difficult for you to control your movements if you've been on Prolixin (fluphenazine) for a while.
  • Mellaril (thioridazine) is only recommended for schizophrenia if other medicines haven't worked because the side effects can be very dangerous.
  • You have to take Mellaril (thioridazine) numerous times a day which can make it hard to remember.
  • Mellaril (thioridazine) can interfere with your heartbeat, so your doctor might have you do annual tests with your heart to make sure it's healthy.
Tips from our pharmacists for people taking the medication
fluphenazinethioridazine
  • Can make you more sensitive to the sun. Wear sunscreen or protective clothing while outside.
  • Can make it difficult for you to start and stop your movements. Talk to your doctor right away if this happens.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
  • Don't stop taking Prolixin (fluphenazine) suddenly. It can be dangerous.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
  • Mix the concentrated form with at least 1/4 cup of fluids. Don't mix with caffeine, tea, or apple juice since it affects the absorption of Prolixin (fluphenazine).
  • Don't stop taking Mellaril (thioridazine) suddenly without talking to your doctor, even if you start to feel well.
  • You can take Mellaril (thioridazine) with or without food. Take it with food if you get an upset stomach.
  • If you've missed a dose of Mellaril (thioridazine), take it as soon as you remember. But if it's time for your next dose, just take your normal amount and don't take extra medicine to make up for the missed dose.
  • Don't drive or do anything requiring concentration until you know how Mellaril (thioridazine) affects you.
  • Don't drink alcohol while taking Mellaril (thioridazine).
Learn more
More about fluphenazineSide effectsAlternativesFDA package insert
Have you used Prolixin (fluphenazine)?
Worth itNot sureNot worth it
More about thioridazineSide effectsAlternativesFDA package insert
Have you used Mellaril (thioridazine)?
Worth itNot sureNot worth it