Compare Fortesta vs. Depo-Testosterone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Fortesta
(testosterone gel)

Depo-Testosterone
(testosterone cypionate injection)

Treats low testosterone. This testosterone gel is a convenient topical form of hormone replacement that's less likely to rub off on other people you come into contact with, but it's not available as a generic yet.Treats low testosterone. This testosterone injection only has to be given once or twice a month and you can do it at home, but someone has to help you inject.
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Reviews & ratings
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Have you used Fortesta (testosterone gel)?
Worth itNot sureNot worth it
Reviews for Depo-Testosterone (testosterone cypionate injection)
49%
-1% worse vs. Fortesta (testosterone gel)
32%
-18% worse vs. Fortesta (testosterone gel)
17%
-17% worse vs. Fortesta (testosterone gel)
100 reviews
Have you used Depo-Testosterone (testosterone cypionate injection)?
Worth itNot sureNot worth it
Side effects
FortestaDepo-Testosterone
  • Skin reaction 16%
More Fortesta side effects »

The Depo-Testosterone FDA package insert doesn’t have numbers about how common side effects are.

More about Depo-Testosterone side effects »
How it works
FortestaDepo-Testosterone
Testosterone gel works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.The testosterone injection works by adding or replacing the hormone testosterone in your body. Testosterone is responsible for causing and maintaining many of the changes in male bodies from puberty on.
Type of medication
FortestaDepo-Testosterone
Prescription only
Prescription only
Available as
FortestaDepo-Testosterone
  • Cream, gel, or ointment
  • Injection
Used for
FortestaDepo-Testosterone
  • Low Testosterone
  • Low Testosterone
Risk factors for serious side effects
FortestaDepo-Testosterone
Coming soon.
  • Male
  • Male
  • Enlarged prostate (benign prostatic hypertrophy)
  • Taking high doses of Depo-Testosterone (Testosterone Cypionate Injection)
  • Heart, liver or kidney disease
  • Inability to move
  • Cancer
      • Diabetes
      • On blood thinners
        Detailed Depo-Testosterone (testosterone cypionate injection) risks & warnings »
        Pregnancy

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        Kidneys and liver
        FortestaDepo-Testosterone
        No kidneys and liver related info.
        • There have been reports of people on Depo-Testosterone (Testosterone Cypionate Injection) who have developed high levels of calcium in the blood, which can be bad for the kidneys. This can happen if you are unable to move around or have cancer. If you notice a metallic taste in your mouth, muscle or joint pain or a bad headache, talk to your doctor, since they may have to stop the medication.
        Upsides and benefits
        FortestaDepo-Testosterone
        • You apply it to your thighs like a lotion.
        • Putting testosterone gel on your thights makes it less likely you'll transfer the medication to other people around you, compared to some other kinds of topical testosterone.
        • A first-choice treatment for low testosterone in men and delayed puberty in boys.
        • Available in generic.
        • Only has to be given once every 2 to 4 weeks.
        • The shot can be done at home.
        Downsides and risks
        FortestaDepo-Testosterone
        • Not available in generic form, so it can be more expensive.
        • You have to wait at least 2 hours after applying testosterone gel before you can swim or bathe, otherwise your body won't absorb the full amount of the medication.
        • Only available as a shot.
        • Has to be given by someone else since it has to be injected into your buttocks.
        Tips from our pharmacists for people taking the medication
        FortestaDepo-Testosterone
        • Prime testosterone gel first by pumping 8 times before you use a new bottle.
        • Don't swim or bathe for at least 2 hours after you apply testosterone gel.
        • Wash your hands with soap and water, and cover the area with clothing as soon as the gel is dry so you don't spread it to other people.
        • If you think you'll have skin-to-skin contact at the area where you've placed testosterone gel, wash that area with soap and water then dry.
        • Don't use testosterone gel anywhere besides your front and inner thighs.
        • Your doctor will show you how to inject this correctly.
        • Can cause nausea, vomiting and headache.
        • Can cause increased acne and changes in sex drive.
        • Keep this medication locked up and away from children since it's a controlled substance.
        Learn more
        More about FortestaSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Fortesta (testosterone gel)?
        Worth itNot sureNot worth it
        More about Depo-TestosteroneSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Depo-Testosterone (testosterone cypionate injection)?
        Worth itNot sureNot worth it