Compare Fosamax vs. Evista

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Fosamax
(Alendronate)

Evista
(Raloxifene)

Prevents bone loss. Fosamax (Alendronate) is a first-choice treatment for osteoporosis and is available as a generic, but taking it can be a hassle.Prevents bone loss and lowers your risk of breast cancer. Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.291666666666667Fosamax
Reviews for Fosamax (Alendronate)
43%
of people say Fosamax (Alendronate) is worth it
30%
say it works well
18%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
FosamaxEvista

We haven’t found good data for Fosamax side effects.

FDA side effect reports for Fosamax »
  • Muscle spasms/leg cramps 4%
  • Leg cramps 3%
  • Sinus inflammation 3%
  • Leg or ankle swelling 2%
  • Muscle pain 2%
  • Sleep difficulty 2%
  • Rash 2%
  • Joint pain 2%
  • Weight gain 2%
  • Any side effect 1%
More Evista side effects »
How it works
FosamaxEvista
Fosamax (Alendronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Evista (Raloxifene) is a selective estrogen receptor modulator (SERM). It acts like estrogen to make your bones stronger and less likely to break, and also protects breast and uterus tissues from other estrogen effects.
Type of medication
FosamaxEvista
BisphosphonatePrescription only
Osteoporosis
Selective estrogen receptor modulator
Prescription only
Available as
FosamaxEvista
  • Pill
  • Effervescent tablet
  • Liquid
  • Pill
Used for (click to learn more)
FosamaxEvista
Risk factors for serious side effects
FosamaxEvista
      • Oral or dental surgery
      • Cancer
      • Poor oral hygiene
          Detailed Fosamax (Alendronate) risks & warnings »
          • History of stroke
          • Heart and blood vessel problems
          • History of mini stroke (TIA)
          • Atrial fibrillation
          • Smoking
          • High blood pressure
            • History of high triglycerides
              Detailed Evista (Raloxifene) risks & warnings »
              Pregnancy category
              FosamaxEvista
              CFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              XFDA pregnancy category (Unsafe)

              Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

              See the FDA package insert
              Alcohol
              No specific alcohol-related info.
              • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
              Food
              No specific food-related info.
              • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
              Kidneys and liver
              No specific kidneys and liver-related info.
              • Evista (Raloxifene) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              No specific weight-related info.No specific weight-related info.
              Upsides and benefits
              FosamaxEvista
              • Lowers your risk of bone fractures.
              • Available as a generic medication.
              • Available in two forms: one that can be taken once a day or another that's taken once a week.
              • Comes as a regular tablet, an oral solution, or effervescent tablets meant to be dissolved in water.
              • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
              • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
              • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).
              Downsides and risks
              FosamaxEvista
              • You need to take it the first thing in the morning with a full glass of water.
              • Not good for people who can't sit or stand upright for at least 30 minutes in the morning.
              • The use of bisphosphonates increases your risk of other types of fractures not related to osteoporosis (called atypical fractures).
              • Can cause bad heartburn or stomach problems.
              • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
              • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
              • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
              • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
              Tips from our pharmacists for people taking the medication
              FosamaxEvista
              • Take Fosamax (Alendronate) first thing in the morning with a full glass of water before eating or drinking anything else, including other medicines.
              • The pill must be swallowed whole.
              • Stay upright for at least 30 minutes after taking the medicine, and don't eat or drink anything except plain water during that time.
              • Make sure you take enough calcium and vitamin D to allow this medicine to work.
              • Can cause an upset stomach, joint pain, back pain, or heartburn.
              • Stop taking the medicine and let your doctor know if swallowing becomes painful, if you have chest pain, or if any of the side effects worsen.
              • If you have dental work coming up, get it done before starting this medicine since some people have experienced serious jaw problems while on Fosamax (Alendronate).
              • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
              • Your doctor may tell you to take calcium and vitamin D with Evista (Raloxifene) to prevent osteoporosis (bone thinning and loss), especially if you don’t get enough in your diet.
              • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
              Learn more
              More about FosamaxSide effectsReviews & ratingsAlternativesFDA package insert
              More about EvistaSide effectsReviews & ratingsAlternativesFDA package insert