Compare Fosamax vs. Reclast

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Fosamax (alendronate)

Prescription only

Reclast (zoledronate)

Prescription only
Prevents bone loss.

Fosamax (alendronate) is a first-choice treatment for osteoporosis, but taking it can be a hassle.

3.2/ 5 average rating with 169 reviewsforFosamax
Prevents bone loss.

Reclast (zoledronate) is a good choice for osteoporosis if you aren't able to take bisphosphonates by mouth. It is available as a generic, but you have to see a doctor to get each dose.

3.1/ 5 average rating with 39 reviewsforReclast
Upsides
  • First choice to treat osteoporosis
  • Lowers your risk of fractures due to osteoporosis.
  • Available generic.
  • Available as daily, weekly, or twice weekly dosing.
  • Comes as a regular tablet, an oral solution, or effervescent tablet.
  • Available in generic.
  • Depending on what you're using it for, you may only need to take it as a one-time dose, or every 1 to 2 years.
Downsides
  • Can harm your esophagus if you don't remain upright for 30 minutes after taking it.
  • Not recommended for people who can't sit or stand upright for at least 30 minutes.
  • Can increase the risk of atypical fractures.
  • Can cause bad heartburn or stomach problems.
  • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
  • It can't be used if you have really poor kidney function.
  • Joint pain and muscle pain are common side effects after the infusion.
Used for
Dosage forms
  • Pill
  • Effervescent tablet
  • Liquid
  • Injection
Price
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Reviews
169 reviews so far
43%
saidit'sworth it
30%
saiditworked well
19%
saidit'sa big hassle

Have you used Fosamax (alendronate)?

Leave a review
39 reviews so far
28%
saidit'sworth it
28%
saiditworked well
36%
saidit'sa big hassle

Have you used Reclast (zoledronate)?

Leave a review
Side effects
1possible side effects
  • Abdominal pain
    2%
See more detailed side effects
17possible side effects
  • Muscle aches
    20%
  • Fatigue
    18%
  • Headache
    15%
  • Muscle pain
    12%
  • Pain
    12%
  • Chills
    10%
  • Influenza-like illness
    9%
  • Stomach pain
    8%
  • Shortness of breath
    7%
  • Feeling unwell
    7%
  • Musculoskeletal stiffness
    5%
  • Lack of energy
    3%
  • Atrial fibrillation
    3%
  • Palpitations
    3%
  • Excessive sweating
    3%
  • Eye pain
    2%
  • Lower kidney function
    2%
See more detailed side effects
Risks and risk factors
  • Irritation and ulcers to the stomach and esophagus
    • Taking anti-inflammatory medicines like ibuprofen, and naproxen
    • History of ulcers or stomach or esophageal conditions
    • Difficulty swallowing
    • Problems sitting or standing for at least 30 minutes
  • Pain in the bones and muscles
  • Problems in the jaw bone
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
    • Prolonged use of Fosamax (alendronate)
  • Leg bone fractures
  • Low calcium in the blood
See more detailed risks and warnings
  • Pain in the bones and muscles
  • Problems in the jawbone
    • Oral or dental surgery
    • Cancer
    • Poor oral hygiene
  • Leg bone fractures
  • Low calcium in the blood
    • Low parathyroid hormone
    • History of thyroid surgery
    • Problems with calcium absorption
  • Kidney injury
    • Kidney disease
    • Taking a water pill
    • Dehydrated
    • Elderly
See more detailed risks and warnings