Compare Frova vs. Onzetra

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Frova
(frovatriptan)

Onzetra
(sumatriptan)

Treats migraine headaches. Triptans are the first-choice to treat migraines. Frova (frovatriptan) works just as well as other triptans for migraines, but doesn't work for other types of headaches like cluster headaches.Treats migraine headaches. Onzetra (sumatriptan) is the only medicine that's available in a breath-powered nose powder to treat migraines. However, it can be expensive compared to other medicines.
Reviews & ratings
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Have you used Frova (frovatriptan)?
Worth itNot sureNot worth it

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Have you used Onzetra (sumatriptan)?
Worth itNot sureNot worth it
Side effects
FrovaOnzetra
  • Dizziness 3%
  • Fatigue 3%
  • Headache 1%
  • Tingling or prickling sensation 2%
  • Flushing 2%
  • Dry mouth 2%
  • Hot or cold sensation 1%
  • Muscle pain 1%
  • Indigestion 1%
  • Chest pain 1%
More Frova side effects »
  • Changes in taste 17%
  • Discomfort in the nose 10%
  • Runny nose 3%
  • Stuffy nose 2%
More Onzetra side effects »
How it works
FrovaOnzetra
Frova (frovatriptan) is a triptan. It prevents the opening of blood vessels in your brain, which causes migraines.Onzetra (sumatriptan) is a selective serotonin receptor agonist called a triptan. It's believed that migraine headaches happen when blood vessels are too open and allow too much blood in the brain. Onzetra (sumatriptan) tightens the blood vessels, which relieves the pain.
Type of medication
FrovaOnzetra
Prescription onlyPrescription only
Available as
FrovaOnzetra
  • Pill
  • Nasal powder
Used for
FrovaOnzetra
Risk factors for serious side effects
FrovaOnzetra
  • Heart disease
  • history of chest pain/angina
  • uncontrolled high blood pressure
  • History of a stroke
  • Using Frova (frovatriptan) for more than 2 to 3 days a week or 10 days a month
Detailed Frova (frovatriptan) risks & warnings »
  • Heart disease
  • History of chest pain
  • Uncontrolled high blood pressure
  • History of a stroke
  • Using Onzetra (sumatriptan) for more than 10 days a month
Detailed Onzetra (sumatriptan) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Sleep
FrovaOnzetra
  • Frova (frovatriptan) can make you dizzy or sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
No sleep related info.
Upsides and benefits
FrovaOnzetra
  • Frova (frovatriptan) is available in generic.
  • Unlike other similar medicines, you can take up to 3 tablets of Frova (frovatriptan) every 24 hours.
  • Frova (frovatriptan) is first choice of medicines for treatment of migraine headaches.
  • Compared to pills, Onzetra (sumatriptan) is better absorbed in the body and good if it's hard to take pills.
  • Onzetra (sumatriptan) is a first choice medicine to treat migraines.
  • There is a copay program available that can make Onzetra (sumatriptan) cheaper.
Downsides and risks
FrovaOnzetra
  • Available as an oral tablet only, which may be difficult to swallow during bad migraine attack.
  • Doesn't prevent migraines.
  • Doesn't work for other types of headaches like cluster headaches.
  • Not recommended for children under 18 years old.
  • It can be very expensive. There are other forms of this same medicine that are much cheaper, including a nose spray.
  • You have to use two nosepieces to get the full dose of Onzetra (sumatriptan), which can be hard to remember.
  • Onzetra (sumatriptan) is only available in one strength.
Tips from our pharmacists for people taking the medication
FrovaOnzetra
  • Doesn't prevent migraines.
  • Use as soon as you feel a migraine starting. You can take another dose 2 hours later, but don't take more than 3 tablets in 24 hours.
  • Don't use it excessively since it can cause you to have more headaches. Talk to your doctor if you are having more than 4 migraines in a month.
  • Frova (frovatriptan) can make you dizzy or sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • Frova (frovatriptan) can cause nausea or tightness in the chest or throat. Talk to your doctor if it bothers you.
  • Follow the instructions exactly as shown by the package insert and your doctor or pharmacist; otherwise, Onzetra (sumatriptan) won't work correctly and you won't get any medicine.
  • Onzetra (sumatriptan) can only treat a migraine that's already happening. You can't use it to stop migraines from starting.
  • You have to use 2 nosepieces of Onzetra (sumatriptan) to get the full dose of medicine.
  • Don't use more than 2 full doses (4 nosepieces) in a 24-hour period.
  • If you're using more than 8 doses of Onzetra (sumatriptan) a month, talk to your doctor to see if you should try another medicine.
  • You can only use each nosepiece of Onzetra (sumatriptan) once. Throw it away in the trash after you've checked that you used the medicine correctly.
Learn more
More about FrovaSide effectsAlternativesFDA package insert
Have you used Frova (frovatriptan)?
Worth itNot sureNot worth it
More about OnzetraSide effectsAlternativesFDA package insert
Have you used Onzetra (sumatriptan)?
Worth itNot sureNot worth it