Compare Genvoya vs. Sustiva

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Genvoya (elvitegravir / cobicistat / emtricitabine / tenofovir)

Prescription only
Treats HIV infection.

Genvoya (elvitegravir / cobicistat / emtricitabine / tenofovir) is a convenient 4-in-1 medication. It's one of the first choices used to treat HIV infections and contains a newer medication that's safer for your kidneys and bones.

Works with other medicines to treat HIV infection.

Sustiva (efavirenz) is one of the most widely used and effective components of an HIV medication regimen. However, it is not a first-line choice because it can have a lot of side effects.

Upsides
  • First-choice treatment for HIV infections.
  • One tablet contains four different HIV medications and is only taken once daily.
  • Genvoya (elvitegravir / cobicistat / emtricitabine / tenofovir) has fewer side effects (headache, nausea, fatigue, diarrhea), and is safer on your kidneys and bones than Stribild.
  • If first-line choices for HIV medications are not an option, Sustiva (efavirenz) would be a good alternative to consider.
  • Only taken once daily.
  • Sustiva (efavirenz) is available in combination tablets.
  • Can be used in patients with mild to moderate kidney damage.
  • Can be used in children who are at least 3 months old.
Downsides
  • Should be taken with food.
  • Can increase cholesterol levels.
  • Can interact with many other drugs.
  • Not suggested for women who plan on becoming pregnant.
  • Many people exerience intolerable side effects (eg. insomnia, dizziness, abnormal dreams, confusion), which make it hard to take the medication regularly.
  • Cannot be taken alone for treatment of HIV.
Used for
Dosage forms
  • Pill
  • Pill
Price
Lowest price near you
$2819.78
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Lowest price near you
$1007.22
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Reviews
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Side effects
4possible side effects
  • Nausea
    10%
  • Diarrhea
    7%
  • Headache
    6%
  • Fatigue
    5%
See more detailed side effects
8possible side effects
  • Skin rash
    16%
  • Diarrhea
    14%
  • Pain
    13%
  • Nausea
    10%
  • Dizziness
    9%
  • Itching
    9%
  • Fatigue
    8%
  • Headache
    8%
See more detailed side effects
Risks and warnings
  • Lactic acidosis | Enlarged, fatty liver

    Liver disease

    ...and 2 more risk factors

  • Worsening hepatitis B infection

    Hepatitis B Virus infection

  • Kidney damage

    History of kidney damage

    ...and 1 more risk factors

  • Immune reconstitution syndrome

    HIV

    ...and 3 more risk factors

  • Drug interactions

    Taking medicines that interact with Genvoya (elvitegravir / cobicistat / emtricitabine / tenofovir)

See more detailed risks and warnings
  • Central nervous system (CNS) effects

    Starting Sustiva (efavirenz) for the first few weeks.

    ...and 1 more risk factors

  • Fat redistribution

    HIV treatment

  • Liver damage

    History of liver damage

    ...and 1 more risk factors

  • Immune reconstitution syndrome

    HIV

    ...and 3 more risk factors

  • Psychiatric effects

    History of mental illness

    ...and 1 more risk factors

  • Rash

    History of severe skin reactions

    ...and 1 more risk factors

See more detailed risks and warnings