Compare Geodon vs. fluphenazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Geodon (Ziprasidone)

Prescription only

Prolixin (fluphenazine)

Prescription only
Helps control your thoughts and mood.

Geodon (Ziprasidone) treats bipolar disorder and schizophrenia, and causes fewer side effects than similar medicines. It’s not a good choice if you have heart problems.

3.4/ 5 average rating with 23 reviewsforGeodon
Treats schizophrenia and psychosis.

Prolixin (fluphenazine) can stabilize your mood. It is used to find the right dose for you before moving to a long-acting injection.

Upsides
  • Geodon (Ziprasidone) can be used with lithium or valproate to better treat bipolar disorder.
  • Geodon (Ziprasidone) can treat agitation in people with schizophrenia by reducing symptoms of anxiety, nervousness, and distress.
  • Compared to other antipsychotics, it has a lower risk of weight gain, hyperglycemia, and hyperlipidemia.
  • The Geodon (Ziprasidone) capsule is available as a generic.
  • The injectable form can treat sudden agitation in schizophrenia when it's not possible to use the capsules.
  • It's available as a pill that you take by mouth daily for continuous treatment and as an injection used for short-term treatment of agitation.
  • Good at stabilizing your mood.
  • Available in several oral and injectable forms, including a long-acting injection that is taken less frequently.
Downsides
  • Elderly people with dementia shouldn’t take Geodon (Ziprasidone).
  • You shouldn’t take Geodon (Ziprasidone) if you have a history of heart problems (slow heart rate, recent heart attack, heart failure, or heart rhythm problems). It’s also not safe to take if you have low potassium or magnesium, or are taking medicines that increase the risk of this happening (diuretics).
  • You'll need to get blood tests before you start taking Geodon (Ziprasidone).
  • It causes slightly less weight gain than similar medicines.
  • Can't take Geodon (Ziprasidone) capsules and injections at the same time. Capsules should be used instead of the injection as soon as possible.
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can make it difficult for you to control your movements if you've been on Prolixin (fluphenazine) for a while.
Used for
Dosage forms
  • Pill
  • Injection
  • Pill
  • Liquid
  • Injection
Price
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Reviews
23 reviews so far
43%
saidit'sworth it
43%
saiditworked well
30%
saidit'sa big hassle

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Side effects
12possible side effects
  • Injection Site Pain
    9%
  • Somnolence
    8%
  • Nausea
    4%
  • Headache
    3%
  • Diarrhea
    3%
  • Dizziness
    3%
  • Insomnia
    3%
  • Asthenia
    2%
  • Hypertension
    2%
  • Anxiety
    2%
  • Agitation
    2%
  • Extrapyramidal Syndrome
    2%
See more detailed side effects
The Prolixin (fluphenazine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • Increased risk of death
    • Elderly patients with dementia
  • Suicidal thoughts or behavior
  • Heart problems
    • History of heart problems
    • Drug interactions
    • Low potassium
    • Low magnesium
  • Neuroleptic malignant syndrome (NMS)
  • Abnormal and involuntary muscle movements
    • Duration of treatment
  • Low blood pressure
  • Risk to fetus
    • Women of childbearing age
See more detailed risks and warnings
  • Increased risk of death
    • People over 65 with dementia and psychosis
  • Difficulty controlling movements
  • Neuroleptic malignant syndrome
    • Taking antipsychotic medications
  • Low white blood cell count
See more detailed risks and warnings