Compare Geodon vs. Invega

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Geodon
(Ziprasidone)

Invega
(Paliperidone)

Helps control your thoughts and mood. Geodon (Ziprasidone) treats bipolar disorder and schizophrenia, and causes fewer side effects than similar medicines. It’s not a good choice if you have heart problems.Helps control your thoughts and mood. Invega (Paliperidone) is good for treating psychosis and improving mood. It's more likely to cause hormone problems than other antipsychotics.
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Reviews & ratings
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Reviews for Invega (Paliperidone)
30%
14% vs. Geodon (Ziprasidone)
33%
11% vs. Geodon (Ziprasidone)
30%
5% vs. Geodon (Ziprasidone)
Side effects
GeodonInvega
  • Drowsiness 19%
  • Extrapyramidal symptoms 19%
  • Dizziness 9%
  • Restlessness 5%
  • Respiratory tract infection 5%
  • Muscle weakness 4%
  • Adverse reaction 3%
  • Vomiting 3%
  • Abnormal vision 3%
  • Accidental injury 2%
More Geodon side effects »
  • Abnormally fast heart beat 7%
  • Anxiety 5%
  • Common cold 4%
  • Indigestion 4%
  • Constipation 3%
  • Positional low blood pressure 3%
  • Muscle weakness 3%
  • Headache 2%
  • Nausea 2%
  • Abdominal discomfort 2%
More Invega side effects »
How it works
GeodonInvega
Geodon (Ziprasidone) is a second generation antipsychotic. It treats schizophrenia and bipolar disorder by adjusting the levels of dopamine and serotonin in your brain, which affects thoughts and mood.Invega (Paliperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affect your thoughts and mood.
Type of medication
GeodonInvega
Antipsychotic
2nd generation
Prescription only
Antipsychotic
Atypical
Prescription only
Available as
GeodonInvega
  • Pill
  • Injection
  • Extended release
  • Injection
Used for (click to learn more)
GeodonInvega
Risk factors for serious side effects
GeodonInvega
  • Elderly patients with dementia
    • History of heart problems
    • Drug interactions
    • Low potassium
    • Low magnesium
      • Duration of treatment
        • Women of childbearing age
        Detailed Geodon (Ziprasidone) risks & warnings »
        • Elderly patients with dementia
            • History of heart problems
            • Drug interactions
              • People with diabetes
              • People with high cholesterol
              • People with diabetes
              • Alcohol
              • Taking other medicines that make you less alert
                Detailed Invega (Paliperidone) risks & warnings »
                Pregnancy category
                GeodonInvega
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                Alcohol
                No specific alcohol-related info.No specific alcohol-related info.
                Food
                • Take Geodon (Ziprasidone) twice a day, preferably with food.
                • Invega (Paliperidone) can increase your blood sugar and cholesterol. Invega (Paliperidone) is moderately likely to raise your blood sugar and cholesterol compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                Kidneys and liver
                No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                Sex
                No specific sex-related info.No specific sex-related info.
                Sleep
                • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
                • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
                Weight
                • It causes slightly less weight gain than similar medicines.
                • Compared to other antipsychotics, it has a lower risk of weight gain, hyperglycemia, and hyperlipidemia.
                • Sometimes causes weight gain and low blood pressure.
                • Invega (Paliperidone) can cause you to gain weight. Invega (Paliperidone) is moderately likely to cause weight gain compared to other antipsychotic medications. Exercise and eat healthy food to lower your risk.
                Upsides and benefits
                GeodonInvega
                • Geodon (Ziprasidone) can be used with lithium or valproate to better treat bipolar disorder.
                • Geodon (Ziprasidone) can treat agitation in people with schizophrenia by reducing symptoms of anxiety, nervousness, and distress.
                • Compared to other antipsychotics, it has a lower risk of weight gain, hyperglycemia, and hyperlipidemia.
                • The Geodon (Ziprasidone) capsule is available as a generic.
                • The injectable form can treat sudden agitation in schizophrenia when it's not possible to use the capsules.
                • It's available as a pill that you take by mouth daily for continuous treatment and as an injection used for short-term treatment of agitation.
                • Effective at relieving psychotic symptoms and relapse rates for people with schizophrenia.
                • Also relieves psychotic symptoms and improves mood for people with schizoaffective disorder.
                • Works just as well as other antipsychotic medicines.
                • Less likely to cause heart or liver problems than some other antipsychotic medications.
                Downsides and risks
                GeodonInvega
                • Elderly people with dementia shouldn’t take Geodon (Ziprasidone).
                • You shouldn’t take Geodon (Ziprasidone) if you have a history of heart problems (slow heart rate, recent heart attack, heart failure, or heart rhythm problems). It’s also not safe to take if you have low potassium or magnesium, or are taking medicines that increase the risk of this happening (diuretics).
                • You'll need to get blood tests before you start taking Geodon (Ziprasidone).
                • It causes slightly less weight gain than similar medicines.
                • Can't take Geodon (Ziprasidone) capsules and injections at the same time. Capsules should be used instead of the injection as soon as possible.
                • Invega (Paliperidone) has a high risk of causing hormone problems that cause nipples to leak fluid and male breasts to grow abnormally large.
                • Sometimes causes weight gain and low blood pressure.
                • Mild risk of causing extrapyramidal symptoms (EPS): movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                • You might need routine blood tests to check how the medicine is affecting your body.
                • Not a good choice for elderly people who have dementia.
                • All antipsychotics have side effects that make them difficult to take. You might need to try a few different medicines until you find one that works best for you.
                Tips from our pharmacists for people taking the medication
                GeodonInvega
                • It usually takes 4 to 6 weeks to see the full effects, so hang in there and wait until it works to figure out the right dose for you.
                • Take Geodon (Ziprasidone) twice a day, preferably with food.
                • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
                • Geodon (Ziprasidone) can cause heart problems, so call your doctor right away if you faint or feel a change in your heartbeat.
                • Let your doctor know if you're taking a diuretic (water pill) or have a condition like chronic diarrhea that'll lower the amount of potassium or magnesium in your blood.
                • It'll take 4 to 6 weeks to see the medication's full effects on thoughts and mood.
                • Can cause dizziness and drowsiness, or worsen you cholesterol and blood sugar levels.
                • For the first week, avoid activities like driving that require you to be alert.
                • Don't worry if you see tablet shells in your stool since the medication was already absorbed by your body.
                • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                • Elderly people who have dementia shouldn't take Invega (Paliperidone).
                Learn more
                More about GeodonSide effectsReviews & ratingsAlternativesFDA package insert
                More about InvegaSide effectsReviews & ratingsAlternativesFDA package insert