Compare Geodon vs. perphenazine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Geodon (Ziprasidone)

Prescription only

Trilafon (perphenazine)

Prescription only
Helps control your thoughts and mood.

Geodon (Ziprasidone) treats bipolar disorder and schizophrenia, and causes fewer side effects than similar medicines. It’s not a good choice if you have heart problems.

4.6/ 7 average rating with 23 reviewsforGeodon
Treats schizophrenia.

Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.

Upsides
  • Geodon (Ziprasidone) can be used with lithium or valproate to better treat bipolar disorder.
  • Geodon (Ziprasidone) can treat agitation in people with schizophrenia by reducing symptoms of anxiety, nervousness, and distress.
  • Compared to other antipsychotics, it has a lower risk of weight gain, hyperglycemia, and hyperlipidemia.
  • The Geodon (Ziprasidone) capsule is available as a generic.
  • The injectable form can treat sudden agitation in schizophrenia when it's not possible to use the capsules.
  • It's available as a pill that you take by mouth daily for continuous treatment and as an injection used for short-term treatment of agitation.
  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
Downsides
  • Elderly people with dementia shouldn’t take Geodon (Ziprasidone).
  • You shouldn’t take Geodon (Ziprasidone) if you have a history of heart problems (slow heart rate, recent heart attack, heart failure, or heart rhythm problems). It’s also not safe to take if you have low potassium or magnesium, or are taking medicines that increase the risk of this happening (diuretics).
  • You'll need to get blood tests before you start taking Geodon (Ziprasidone).
  • It causes slightly less weight gain than similar medicines.
  • Can't take Geodon (Ziprasidone) capsules and injections at the same time. Capsules should be used instead of the injection as soon as possible.
  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
Used for
Dosage forms
  • Pill
  • Injection
  • Pill
Price
Lowest price near you
$31.52
Find instant savings
No pricing information available
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
23 
43%
think this treatment is worth it
43%
think this treatment works well
30%
think this treatment is a hassle

Have you used Geodon (Ziprasidone)?

Leave a review
Not enough review data.Leave a review
Side effects
10possible side effects
  • Injection Site Pain
    9%
  • Somnolence
    8%
  • Nausea
    4%
  • Headache
    3%
  • Diarrhea
    3%
  • Dizziness
    3%
  • Insomnia
    3%
  • Asthenia
    2%
  • Hypertension
    2%
  • Anxiety
    2%
See more detailed side effects
The Trilafon (perphenazine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Increased risk of death

    Elderly patients with dementia

  • Heart problems

    History of heart problems

    ...and 3 more risk factors

  • Abnormal and involuntary muscle movements

    Duration of treatment

  • Risk to fetus

    Women of childbearing age

See more detailed risks and warnings
  • Higher risk of death

    People age 65 or older with dementia and psychosis

  • Sleepiness

    Drinking alcohol or taking narcotics

See more detailed risks and warnings