Compare Geodon vs. Risperdal

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Geodon
(Ziprasidone)

Risperdal
(Risperidone)

Helps control your thoughts and mood. Geodon (Ziprasidone) treats bipolar disorder and schizophrenia, and causes fewer side effects than similar medicines. It’s not a good choice if you have heart problems.Helps control your thoughts and mood. Risperdal (Risperidone) is good for treating psychosis, mania, and irritability. Among newer antipsychotic medicines, more likely to cause side effects, especially weight gain and hormone problems.
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Reviews & ratings
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Reviews for Risperdal (Risperidone)
48%
+4% vs. Geodon (Ziprasidone)
41%
3% vs. Geodon (Ziprasidone)
48%
23% vs. Geodon (Ziprasidone)
Side effects
GeodonRisperdal
  • Drowsiness 19%
  • Extrapyramidal symptoms 19%
  • Dizziness 9%
  • Restlessness 5%
  • Respiratory tract infection 5%
  • Muscle weakness 4%
  • Adverse reaction 3%
  • Vomiting 3%
  • Abnormal vision 3%
  • Accidental injury 2%
More Geodon side effects »
  • Relaxation or sleepiness 48%
  • Increased appetite 29%
  • Fatigue 22%
  • Parkinsonism 17%
  • Constipation 11%
  • Dizziness 11%
  • Abdominal pain upper 11%
  • Common cold 10%
  • Nausea 9%
  • Indigestion 8%
More Risperdal side effects »
How it works
GeodonRisperdal
Geodon (Ziprasidone) is a second generation antipsychotic. It treats schizophrenia and bipolar disorder by adjusting the levels of dopamine and serotonin in your brain, which affects thoughts and mood.Risperdal (Risperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
GeodonRisperdal
Antipsychotic
2nd generation
Prescription only
Antipsychotic
Atypical
Prescription only
Available as
GeodonRisperdal
  • Pill
  • Injection
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
Used for (click to learn more)
GeodonRisperdal
Risk factors for serious side effects
GeodonRisperdal
  • Elderly patients with dementia
    • History of heart problems
    • Drug interactions
    • Low potassium
    • Low magnesium
      • Duration of treatment
        • Women of childbearing age
        Detailed Geodon (Ziprasidone) risks & warnings »
        • Elderly patients with dementia
            • History of heart problems
            • Drug interactions
              • People with diabetes
              • People with high cholesterol
              • People with diabetes
              • Alcohol
              • Taking other medicines that make you less alert
                Detailed Risperdal (Risperidone) risks & warnings »
                Pregnancy category
                GeodonRisperdal
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                CFDA pregnancy category (Weigh risks vs. benefits)

                Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                See the FDA package insert
                Alcohol
                No specific alcohol-related info.No specific alcohol-related info.
                Food
                • Take Geodon (Ziprasidone) twice a day, preferably with food.
                • Risperdal (Risperidone) can increase your blood sugar and cholesterol. Exercise and eat healthy food to lower your risk.
                • Risperdal (Risperidone) can cause you to gain weight. Exercise and eat healthy food to lower your risk.
                Kidneys and liver
                No specific kidneys and liver-related info.No specific kidneys and liver-related info.
                Sex
                No specific sex-related info.No specific sex-related info.
                Sleep
                • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
                • Can cause dizziness and drowsiness.
                Weight
                • It causes slightly less weight gain than similar medicines.
                • Compared to other antipsychotics, it has a lower risk of weight gain, hyperglycemia, and hyperlipidemia.
                • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                • May cause weight gain and worsen cholesterol or blood sugar.
                • Risperdal (Risperidone) can cause you to gain weight. Exercise and eat healthy food to lower your risk.
                Upsides and benefits
                GeodonRisperdal
                • Geodon (Ziprasidone) can be used with lithium or valproate to better treat bipolar disorder.
                • Geodon (Ziprasidone) can treat agitation in people with schizophrenia by reducing symptoms of anxiety, nervousness, and distress.
                • Compared to other antipsychotics, it has a lower risk of weight gain, hyperglycemia, and hyperlipidemia.
                • The Geodon (Ziprasidone) capsule is available as a generic.
                • The injectable form can treat sudden agitation in schizophrenia when it's not possible to use the capsules.
                • It's available as a pill that you take by mouth daily for continuous treatment and as an injection used for short-term treatment of agitation.
                • Effective at relieving psychotic symptoms, manic episodes, irritability, and aggressive behavior.
                • Lowers relapse rates in people with schizophrenia and people with irritability associated with autism.
                • Antipsychotic medicines are all about equally effective.
                • Less likely to cause heart problems than some antipsychotics.
                Downsides and risks
                GeodonRisperdal
                • Elderly people with dementia shouldn’t take Geodon (Ziprasidone).
                • You shouldn’t take Geodon (Ziprasidone) if you have a history of heart problems (slow heart rate, recent heart attack, heart failure, or heart rhythm problems). It’s also not safe to take if you have low potassium or magnesium, or are taking medicines that increase the risk of this happening (diuretics).
                • You'll need to get blood tests before you start taking Geodon (Ziprasidone).
                • It causes slightly less weight gain than similar medicines.
                • Can't take Geodon (Ziprasidone) capsules and injections at the same time. Capsules should be used instead of the injection as soon as possible.
                • Mild to moderate risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
                • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
                • Compared to other antipsychotics, higher risk of hormone problems that cause nipples to leak and male breasts to grow abnormally large.
                • You might need routine blood tests to check how the medicine is affecting your body.
                • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                Tips from our pharmacists for people taking the medication
                GeodonRisperdal
                • It usually takes 4 to 6 weeks to see the full effects, so hang in there and wait until it works to figure out the right dose for you.
                • Take Geodon (Ziprasidone) twice a day, preferably with food.
                • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
                • Geodon (Ziprasidone) can cause heart problems, so call your doctor right away if you faint or feel a change in your heartbeat.
                • Let your doctor know if you're taking a diuretic (water pill) or have a condition like chronic diarrhea that'll lower the amount of potassium or magnesium in your blood.
                • Takes 4 to 6 weeks to see full effects on thoughts and mood.
                • Can cause dizziness and drowsiness.
                • For the first week, avoid activities that require you to be alert.
                • May cause weight gain and worsen cholesterol or blood sugar.
                • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
                • Elderly people with dementia shouldn't take it.
                Learn more
                More about GeodonSide effectsReviews & ratingsAlternativesFDA package insert
                More about RisperdalSide effectsReviews & ratingsAlternativesFDA package insert