Compare Geodon vs. Saphris

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Geodon
(ziprasidone)

Saphris
(asenapine)

Helps control your thoughts and mood. Geodon (Ziprasidone) treats bipolar disorder and schizophrenia, and causes fewer side effects than similar medicines. It’s not a good choice if you have heart problems.Treats bipolar disorder and schizophrenia. While Saphris (asenapine) has fewer side effects compared with other medicines that treat bipolar disorder and schizophrenia, it can be more expensive.
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Prices and coupon for 30 (40mg) capsules of ziprasidone
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Prices and coupon for 30 (10mg) orally disintegrating tabs of asenapine
Reviews & ratings
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Have you used Geodon (ziprasidone)?
Worth itNot sureNot worth it

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Have you used Saphris (asenapine)?
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Side effects
GeodonSaphris
  • Extrapyramidal symptoms 6%
  • Drowsiness 7%
  • Nausea 3%
  • Constipation 1%
  • Respiratory tract infection 5%
  • Dizziness 2%
  • Indigestion 1%
  • Restlessness 1%
  • Muscle weakness 2%
  • Diarrhea 1%
More Geodon side effects »
  • Trouble sleeping 2%
  • Sleepiness 6%
  • Difficulty controlling movements 3%
  • Restlessness 3%
  • Numbness in the mouth 4%
  • Dizziness 1%
  • Weight gain 2%
More Saphris side effects »
How it works
GeodonSaphris
Geodon (Ziprasidone) is a second generation antipsychotic. It treats schizophrenia and bipolar disorder by adjusting the levels of dopamine and serotonin in your brain, which affects thoughts and mood.While it's not clear how Saphris (asenapine) helps to treat bipolar disorder or schizophrenia, it changes the amount of dopamine and serotonin in the brain, two chemicals that are known to regulate mood.
Type of medication
GeodonSaphris
Prescription only
Prescription only
Available as
GeodonSaphris
  • Pill
  • Injection
  • Dissolving pill
Used for
GeodonSaphris
Risk factors for serious side effects
GeodonSaphris
  • Elderly patients with dementia
    • History of heart problems
    • Drug interactions
    • Low potassium
    • Low magnesium
      • Duration of treatment
        • Women of childbearing age
        Detailed Geodon (ziprasidone) risks & warnings »
        • People age 65 or older with dementia and psychosis
        • Taking antipsychotic medications
            • High blood pressure
            • History of heart disease
              Detailed Saphris (asenapine) risks & warnings »
              Pregnancy

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Sleep
              GeodonSaphris
              • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
              No sleep related info.
              Weight
              GeodonSaphris
              • It causes slightly less weight gain than similar medicines.
              • People on medicines like Saphris (asenapine) have had weight gain and higher blood sugar to the point of having diabetes. Your doctor will work with you to stop that from happening.
              Upsides and benefits
              GeodonSaphris
              • Geodon (Ziprasidone) can be used with lithium or valproate to better treat bipolar disorder.
              • Geodon (Ziprasidone) can treat agitation in people with schizophrenia by reducing symptoms of anxiety, nervousness, and distress.
              • Compared to other antipsychotics, it has a lower risk of weight gain, hyperglycemia, and hyperlipidemia.
              • The Geodon (Ziprasidone) capsule is available as a generic.
              • The injectable form can treat sudden agitation in schizophrenia when it's not possible to use the capsules.
              • It's available as a pill that you take by mouth daily for continuous treatment and as an injection used for short-term treatment of agitation.
              • Saphris (asenapine) can be used to treat bipolar disorder in children age 10 or older, and schizophrenia in children age 12 or older.
              • You don't need water to take Saphris (asenapine); the pill dissolves in your mouth right away.
              • Compared to other medicines, the side effects of Saphris (asenapine) are milder.
              Downsides and risks
              GeodonSaphris
              • Elderly people with dementia shouldn’t take Geodon (Ziprasidone).
              • You shouldn’t take Geodon (Ziprasidone) if you have a history of heart problems (slow heart rate, recent heart attack, heart failure, or heart rhythm problems). It’s also not safe to take if you have low potassium or magnesium, or are taking medicines that increase the risk of this happening (diuretics).
              • You'll need to get blood tests before you start taking Geodon (Ziprasidone).
              • It causes slightly less weight gain than similar medicines.
              • Can't take Geodon (Ziprasidone) capsules and injections at the same time. Capsules should be used instead of the injection as soon as possible.
              • Saphris (asenapine) is only available as a brand name.
              • Compared to other medicines, Saphris (asenapine) can cause changes in your hormones and make you sleepy.
              • You have to take Saphris (asenapine) twice a day, which can be hard to remember.
              Tips from our pharmacists for people taking the medication
              GeodonSaphris
              • It usually takes 4 to 6 weeks to see the full effects, so hang in there and wait until it works to figure out the right dose for you.
              • Take Geodon (Ziprasidone) twice a day, preferably with food.
              • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
              • Geodon (Ziprasidone) can cause heart problems, so call your doctor right away if you faint or feel a change in your heartbeat.
              • Let your doctor know if you're taking a diuretic (water pill) or have a condition like chronic diarrhea that'll lower the amount of potassium or magnesium in your blood.
              • To take Saphris (asenapine), place the pill under your tongue and let it dissolve completely. Don't chew or swallow the pill, and don't eat or drink for 10 minutes after you take it.
              • You might feel numbness or tingling in your mouth or throat after you take Saphris (asenapine). This usually goes away after an hour.
              • Don't drive or do anything requiring concentration until you know how Saphris (asenapine) affects you.
              • Don't stop taking Saphris (asenapine) suddenly without talking to your doctor first because it can be very dangerous.
              • If you miss a dose of Saphris (asenapine), take it as soon as you remember, unless it’s time for your next dose; don't take 2 doses at the same time.
              • Keep Saphris (asenapine) in your pantry away from heat, moisture, and light. Don't store it in your bathroom's medicine cabinet.
              Learn more
              More about GeodonSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Geodon (ziprasidone)?
              Worth itNot sureNot worth it
              More about SaphrisSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Saphris (asenapine)?
              Worth itNot sureNot worth it