Compare Gilenya vs. Aubagio

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Gilenya
(Fingolimod)

Aubagio
(Teriflunomide)

Treats relapsing forms of multiple sclerosis. Gilenya (Fingolimod) is an oral medication that has a lot of side effects, but it reduces the number of flare-ups, slows physical changes, and decreases the number of new brain lesions in relapsing MS.Treats relapsing forms of MS. Aubagio (Teriflunomide) is an oral medicine that effectively reduces the number of flare-ups, slows physical changes, and decreases the number of new brain lesions in relapsing MS. Because it stays in the body for so long, if you have a serious reaction or possible pregnancy you'll need to have it quickly removed with another medicine.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4Gilenya
Reviews for Gilenya (Fingolimod)
42%
of people say Gilenya (Fingolimod) is worth it
30%
say it works well
30%
say it's a big hassle
Reviews for Aubagio (Teriflunomide)
40%
2% vs. Gilenya (Fingolimod)
25%
5% vs. Gilenya (Fingolimod)
35%
5% vs. Gilenya (Fingolimod)
Side effects
GilenyaAubagio
  • Alt/ast increased 9%
  • Diarrhea 5%
  • Back pain 5%
  • Ggt increased 4%
  • Bronchitis 4%
  • Migraine 4%
  • Vission blurred 3%
  • Abnormally slow heartbeat 3%
  • Influenza viral infections 3%
  • Tinea infections 3%
More Gilenya side effects »
  • Hair loss or baldness 10%
  • Diarrhea 9%
  • Mild hypophospatemia 9%
  • Alanine aminotransferase increased 7%
  • Nausea 7%
  • Headache 4%
  • Moderate hypophospatemia 4%
  • Gamma-glutamyltransferase increase 4%
  • Gastroenteritis viral 3%
  • Bladder infection 3%
More Aubagio side effects »
How it works
GilenyaAubagio
Gilenya (Fingolimod) is an immune modulator. Researchers don't know exactly how it works, but it seems to stop your white blood cells from attacking the nerves in your brain and spinal cord.Aubagio (Teriflunomide) is an immune modulator. Researchers don't know exactly how it works for MS, but it seems to lower your white blood cells and keep them from attacking the nerves in your brain and spinal cord.
Type of medication
GilenyaAubagio
Multiple sclerosis treatment, Immunosuppressant
Immunomodulator
Prescription only
Multiple Sclerosis treatment
Pyrimidine synthesis inhibitor
Prescription only
Available as
GilenyaAubagio
  • Pill
  • Pill
Used for (click to learn more)
GilenyaAubagio
Risk factors for serious side effects
GilenyaAubagio
  • Taking with drugs that slow heart rate
  • History of heart problems
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • Weak immune system
    • Diabetes
    • History of eye inflammation (uveitis)
    • Women of childbearing age
    • History of respiratory problems
    • History of liver problems
    Detailed Gilenya (Fingolimod) risks & warnings »
    • Taking medicines that affect your liver or cause liver injury
        • Reaction to leflunomide
        • Age 60 or older
        • Taking medicines that are toxic to the nervous system
        • Diabetes
        • Taking other immunosuppressant drugs
        • Age 60 or older
        • Weak immune system
        • High uric acid levels
          • Acute kidney failure
          • History of lung disease
          • History of high blood pressure
          Detailed Aubagio (Teriflunomide) risks & warnings »
          Pregnancy category
          GilenyaAubagio
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          XFDA pregnancy category (Unsafe)

          Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Take one capsule daily with or without food.
          • It comes a 7 mg and 14mg dose and only needs to be taken once a day, with or without food.
          • Take one capsule daily with or without food.
          Kidneys and liver
          No specific kidneys and liver-related info.
          • Aubagio can also cause serious and life-threatening liver, lung, skin, kidney and blood pressure effects.
          • People taking Aubagio (Teriflunomide) had temporary acute kidney failure thought to be due to high uric acid buildup in the kidneys (uric acid nephropathy). Kidney function started to decrease from 12 weeks to 2 years after the first dose, then returned to normal with continued dosing. It’s not completely clear is there were other reasons for this effect and people generally didn't have any symptoms.
          • Aubagio (Teriflunomide) has caused high blood potassium levels in people that also had acute kidney failure. Your doctor will do tests to check your potassium levels especially if you already have kidney problems.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          GilenyaAubagio
          • Gilenya (Fingolimod) is the first once-daily pill you can take for relapsing forms of multiple sclerosis (MS).
          • Studies show it lowers relapse rates better than placebo and Avonex, and it delays the progression of physical disabilites better than placebo.
          • Gilenya also reduced the number of new MS lesions better than Avonex.
          • You can take it by mouth.
          • It comes a 7 mg and 14mg dose and only needs to be taken once a day, with or without food.
          • In clinical studies, Aubagio reduced relapses, slowed disability, and decreased the number of new brain lesions compared to sugar pill (placebo).
          • Although it may not work for everyone, most people felt it wasn't much of a hassle.
          Downsides and risks
          GilenyaAubagio
          • Taking more than the 0.5 mg dose won't give more benefits, but will only cause more side effects.
          • Gilenya can remain in your blood for up to 2 months after you stop taking it. Your immune response won't work as well during this time.
          • Not the best choice if you've had a heart attack, stroke, or have been in the hospital for heart failure in the past 6 months. The risk of serious heart rate effects is higher when taken with certain drugs (methadone, erythromycin, citalopram, ketoconazole) or if you have low potassium or magnesium.
          • If you have to re-start Gilenya after stopping it for 2 weeks or more, you'll have to take your first dose at your doctor's office again.
          • If you didn't get chicken pox and never had a vaccination, you'll need to be vaccinated and wait one month before starting Gilenya.
          • Some people have nausea and diarrhea when they start treatment. In most cases, these effects are mild and get better over time.
          • Aubagio can cause your hair to thin. This is temporary, and your hair will go back to normal after a few months.
          • You should have certain lab tests to make sure you don't have any problems from taking Aubagio. These include: complete blood count and liver enzyme testing within 6 months before you start treatment, tuberculosis (TB) screening, and blood pressure.
          • Numbness or tingling in your hands and feet (peripheral neuropathy), different from MS was reported more often than with sugar pill (placebo)
          • Aubagio may stay in your blood up to 2 years after you stop taking it. You can quickly remove Aubagio the accelerated elimination procedure, but symptoms of your disease may return.
          • You can't take it if you're pregnant.
          Tips from our pharmacists for people taking the medication
          GilenyaAubagio
          • It's very important you read the Gilenya Medication Guide. Don't change your dose or stop the medicine without asking your doctor.
          • You'll need to be watched for at least 6 hours in a doctor's office after taking your first dose because it can cause serious heart rate and blood pressure problems.
          • Gilenya increases your risk of infections. Get blood tests 6 months before starting treatment.
          • Use effective birth control or plan to stop Gilenya 2 months before getting pregnant. If you do become pregnant while on Gilenya (Fingolimod), you'll need to enroll in the Gilenya pregnancy registry.
          • Tell your doctor if you've had any vaccines recently. Don't get any live vaccines while taking Gilenya.
          • Your doctor will monitor your eyes, lungs, and liver for up to 2 months after stopping Gilenya.
          • Take one capsule daily with or without food.
          • It's very important you read the Aubagio Medication Guide.
          • Most common side effects are diarrhea, nausea, hair thinning, and elevated liver blood levels.
          • Not the best choice if you have liver problems or are on medications that affect the liver.
          • Liver blood tests need to be done for 6 months once you start taking Aubagio. If these tests are abnormal and liver damage is suspected your doctor will stop the medicine and tell you to start taking cholestyramine for 11 days to lower the toxic level.
          • You'll need to have a TB test before you start taking Aubagio.
          • Can cause numbness and tingling of your hands and feet. Let your doctor know if this becomes a problem.
          • Aubagio increases your risk of infections so tell your doctor if you notice a fever, cough that doesn't go away, or flu-like symptoms. Get your blood counts checked 6 months before starting treatment.
          • Aubagio can also cause serious and life-threatening liver, lung, skin, kidney and blood pressure effects.
          • Aubagio will harm your unborn baby and is pregnancy category X. You must have a negative pregnancy test before starting Aubagio.
          • Both men and women are affected. If they want to have a baby both need to stop taking Aubagio and begin rapid removal process using cholestyramine or activated charcoal for 11 days. Without this process, Aubagio will stay in the body for up to 2 years.
          • Take one capsule daily with or without food.
          Learn more
          More about GilenyaSide effectsReviews & ratingsAlternativesFDA package insert
          More about AubagioSide effectsReviews & ratingsAlternativesFDA package insert