Compare Glucotrol vs. Byetta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glucotrol
(Glipizide)

Byetta
(Exenatide)

Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers your blood sugar. Byetta (Exenatide) helps lower blood sugar for people with diabetes and causes weight loss, but it has to be given by injection and many people have upset stomach.
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Reviews & ratings
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4.2696969696969695Glucotrol
Reviews for Glucotrol (Glipizide)
50%
of people say Glucotrol (Glipizide) is worth it
32%
say it works well
19%
say it's a big hassle

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Side effects
GlucotrolByetta
  • Passing gas 2%
  • Dizziness 1%
  • Nervousness 1%
More Glucotrol side effects »
  • Low blood sugar 33%
  • Nausea 26%
  • Vomiting 14%
  • Headache 10%
  • Diarrhea 10%
  • Constipation 8%
  • Indigestion 6%
  • Feeling jittery 5%
  • Muscle weakness 4%
  • Dizziness 3%
More Byetta side effects »
How it works
GlucotrolByetta
Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Byetta (Exenatide) is a medication for diabetes. It stimulates your body to produce and release more insulin, lower the sugar hormone (glucagon), and slow down digestion.
Type of medication
GlucotrolByetta
Anti-diabetic
Sulfonylurea
Prescription only
Anti-diabetic
Incretin mimetic
Prescription only
Available as
GlucotrolByetta
  • Pill
  • Extended release
  • Injection
Used for (click to learn more)
GlucotrolByetta
Risk factors for serious side effects
GlucotrolByetta
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
    • History of sulfa allergies
    Detailed Glucotrol (Glipizide) risks & warnings »
          • Severe renal impairment
          • End-stage renal disease
          • Severe gastrointestinal disease
          • Gastroparesis
            Detailed Byetta (Exenatide) risks & warnings »
            Pregnancy category
            GlucotrolByetta
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            CFDA pregnancy category (Weigh risks vs. benefits)

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            See the FDA package insert
            Alcohol
            • Avoid drinking alcohol.
            No specific alcohol-related info.
            Food
            • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
            • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
            • Eat regular, balanced meals to avoid low blood sugar.
            • Give injections in your belly, thighs, or upper arm within an hour of your two main meals of the day (separate doses by 6 or more hours).
            • Eat regular, balanced meals to avoid low blood sugar.
            Kidneys and liver
            • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
            • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.No specific sleep-related info.
            Weight
            • Can cause mild weight gain (2 to 3 pounds).
            • Can cause weight gain, dizziness, or stomach upset.
            • Can lower your appetite by making you feel full. Some people also lose weight when taking Byetta (Exenatide).
            Upsides and benefits
            GlucotrolByetta
            • Oral blood sugar-lowering medicine.
            • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
            • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
            • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
            • One of the least expensive diabetes medicines.
            • Lowers A1c levels by 1% (A1c measures your average blood sugar over time.)
            • Prevents the harmful effects of high sugar levels on your organs.
            • Has a lower chance of causing low blood sugar than medications like glyburide or insulin.
            • Can lower your appetite by making you feel full. Some people also lose weight when taking Byetta (Exenatide).
            • Byetta (Exenatide) is not a replacement for diabetes pills, but you may be able to use it alone without the need for pills.
            • The injectable “pen” has easy to use doses which you may find more convenient than other types of injections.
            Downsides and risks
            GlucotrolByetta
            • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
            • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
            • Can cause mild weight gain (2 to 3 pounds).
            • Loses effectiveness over time or as your body stops making insulin.
            • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
            • Only lowers A1c levels by 1%, which may not be enough to get your blood sugar in the safe range.
            • Byetta (Exenatide) must be injected twice a day.
            • Up to 40% of people taking Byetta (Exenatide) have upset stomach and side effects like nausea, vomiting, diarrhea, constipation, or indigestion.
            • Because Byetta (Exenatide) can interact with antibiotics and birth control pills, you can't take it until one hour after these medications.
            • Other diabetes medications work as well and are cheaper.
            Tips from our pharmacists for people taking the medication
            GlucotrolByetta
            • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
            • Can cause weight gain, dizziness, or stomach upset.
            • Avoid drinking alcohol.
            • Check your blood sugar regularly.
            • Eat regular, balanced meals to avoid low blood sugar.
            • Store in the refrigerator until opening. Do not freeze.
            • Give injections in your belly, thighs, or upper arm within an hour of your two main meals of the day (separate doses by 6 or more hours).
            • Change the needle and prime the pen every time you inject.
            • It’s not safe to share this medication with other people, even if you change the needle.
            • Don’t mix with insulin; give separate injections. Can be given at the same time as insulin, but in different injection areas.
            • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure your medication is working and is safe. Some people may need to test more often, ask your doctor.
            • Eat regular, balanced meals to avoid low blood sugar.
            Learn more
            More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
            More about ByettaSide effectsReviews & ratingsAlternativesFDA package insert