Compare Glucotrol vs. Byetta

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Lowers blood sugar. Glucotrol (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low so you must always carry some form of sugar with you that can be readily used.Lowers blood sugar. Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.
Reviews & ratings
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Reviews for Glucotrol
of people (All ages) say Glucotrol is worth it
say it works well
say it's a big hassle
332 reviews
Have you used Glucotrol (glipizide)?
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Have you used Byetta (Exenatide)?
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Side effects
  • Passing gas 2%
  • Low blood sugar 3%
  • Nervousness 1%
  • Tremor 4%
  • Diarrhea 5%
  • Dizziness 1%
  • Headache 2%
  • Constipation 3%
  • Nausea 3%
More Glucotrol side effects »
  • Low blood sugar 11%
  • Gas 1%
  • Gastroesophageal reflux disease (GERD) 1%
  • Loss of appetite 3%
  • Abdominal swelling 3%
  • Weakness 4%
  • Indigestion 5%
  • Constipation 8%
  • Headache 10%
  • Vomiting 14%
More Byetta side effects »
How it works
Glucotrol (glipizide) stimulates your body to release insulin and lower blood sugar.Byetta (Exenatide) enhances the release of insulin in your gut and pancreas to lower your blood sugar.
Type of medication
Prescription onlyLower-cost generic availablePrescription onlyNo lower cost generic available
Available as
  • Pill
  • Extended release pill
  • Injection
Used for
Risk factors for serious side effects
  • Skipping meals or having inconsistent meal times
  • Drinking alcohol
  • Using other blood sugar-lowering medicine
  • People age 60 or older
  • Those with kidney and/or liver problems
Detailed Glucotrol (glipizide) risks & warnings »
  • Severe renal impairment
  • End-stage renal disease
  • Severe gastrointestinal disease
  • Gastroparesis
Detailed Byetta (Exenatide) risks & warnings »

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

  • Avoid drinking alcohol while taking Glucotrol (glipizide).
No alcohol related info.
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
No food related info.
Kidneys and liver
No kidneys and liver related info.
  • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
No pain related info.
  • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medicine for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
  • Can cause mild weight gain of 2-3lb.
No weight related info.
Upsides and benefits
  • Lowers A1c levels by 1-2%.
  • Glucotrol (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Okay to use by people with kidney problems.
  • Available as a generic form and is relatively cheap.
  • Can lower your A1c (average blood sugar over time) by 1%.
  • Not as likely to cause very low blood sugar as glyburine or insulin.
  • Does not increase your appetite like other anti-diabetic medicines.
  • Pen is dialed to a single dose for easy injections.
Downsides and risks
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • While taking Glucotrol (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
  • Can cause mild weight gain of 2-3lb.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
  • Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
  • It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
  • Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
Tips from our pharmacists for people taking the medication
  • Take the medicine 30 minutes before eating, usually before your first big meal of the day.
  • Avoid drinking alcohol while taking Glucotrol (glipizide).
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
  • Check your blood sugar regularly.
  • Glucotrol (glipizide) can cause dizziness so avoid activities that require coordination until you know how your body can handle the medicine.
  • Inject into your belly, thighs, or upper arms within an hour of your main meals.
  • Store unused pens in the refrigerator.
  • After first use, pens can be kept at room temperature for 30 days.
  • Change the needle and prime the pen every time you inject.
  • If you're also on insulin, don't inject into the same site.
  • Best to check your blood sugar once a day to make sure your medicine is working properly.
Learn more
More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
More about ByettaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Byetta (Exenatide)?
Worth itNot sureNot worth it