Compare Glucotrol vs. Glucovance

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glucotrol
(glipizide)

Glucovance
(metformin / glyburide)

Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Glucovance (Metformin / Glyburide) is a very effective combo medication to lower blood sugar when taking one medication alone isn't enough. It's likely to cause diarrhea for the first few weeks, and you can’t drink much alcohol.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Glucotrol
Best available price for 60 (5mg) tablets of glipizide
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.29Glucotrol
Reviews for Glucotrol (glipizide)
50%
of people (All ages) say Glucotrol (glipizide) is worth it
32%
say it works well
19%
say it's a big hassle
332 reviews
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
Reviews for Glucovance (metformin / glyburide)
Not enough review data. Review it!
-50% worse vs. Glucotrol (glipizide)
Not enough review data. Review it!
-32% worse vs. Glucotrol (glipizide)
Not enough review data. Review it!
+19% better vs. Glucotrol (glipizide)
Have you used Glucovance (metformin / glyburide)?
Worth itNot sureNot worth it
Side effects
GlucotrolGlucovance
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Drowsiness 2%
More Glucotrol side effects »
  • Upper respiratory infection 3%
  • Diarrhea 11%
  • Nausea/vomiting 2%
  • Abdominal pain 3%
  • Dizziness 2%
  • Gi side effects 8%
  • Low blood sugar 8%
More Glucovance side effects »
How it works
GlucotrolGlucovance
Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Glucovance (Metformin / Glyburide) is a combination medication for diabetes. Metformin lowers sugar (glucose) production in your body, decreases the amount of glucose getting into your blood, and makes your body more sensitive to insulin. Glyburide helps your body make more insulin to lower blood sugar.
Type of medication
GlucotrolGlucovance
Prescription only
Prescription only
Available as
GlucotrolGlucovance
  • Pill
  • Extended release
  • Pill
Used for
GlucotrolGlucovance
Risk factors for serious side effects
GlucotrolGlucovance
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
  • History of sulfa allergies
Detailed Glucotrol (glipizide) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Glucovance (metformin / glyburide) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
GlucotrolGlucovance
  • Avoid drinking alcohol.
  • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
  • Try limiting the amount of alcohol you drink while taking this medication.
Food
GlucotrolGlucovance
  • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
  • Eat regular, balanced meals to avoid low blood sugar.
No food related info.
Kidneys and liver
GlucotrolGlucovance
  • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
  • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
  • Glucovance (Metformin / Glyburide) can cause lactic acidosis, a rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucovance (Metformin / Glyburide). It may not be a good choice for people with kidney problems. Glucovance (Metformin / Glyburide) should be stopped 48 hours before and/or after surgery or procedure that'll use contrast dye.
Weight
GlucotrolGlucovance
  • Can cause mild weight gain (2 to 3 pounds).
  • Can cause weight gain, dizziness, or stomach upset.
  • Can cause some weight gain.
Upsides and benefits
GlucotrolGlucovance
  • Oral blood sugar-lowering medicine.
  • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
  • One of the least expensive diabetes medicines.
  • A combination medication that lowers your blood sugar in multiple ways. It's used by people who need tighter control of their blood sugar.
  • Can greatly lower A1c levels. The Hemoglobin A1c test measures your average blood sugar levels over the last few months.
  • Prevents harmful effects of high blood sugar levels on your organs and blood vessels.
  • Also lowers certain lipid (fat and cholesterol) levels.
Downsides and risks
GlucotrolGlucovance
  • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
  • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
  • Can cause mild weight gain (2 to 3 pounds).
  • Loses effectiveness over time or as your body stops making insulin.
  • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
  • There's a higher risk of low blood sugar episodes than with other kinds of oral diabetes medications.
  • Most people will have nausea, stomach upset, or diarrhea in the first few weeks. You can lower these symptoms if you take it on a full stomach.
  • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
  • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
  • Can cause some weight gain.
Tips from our pharmacists for people taking the medication
GlucotrolGlucovance
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Avoid drinking alcohol.
  • Eat regular, balanced meals to avoid low blood sugar.
  • Check your blood sugar regularly.
  • Can cause upset stomach, nausea, and diarrhea in the first couple of weeks.
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Tell your doctor about any deep or rapid breathing, persistent nausea, vomiting, or stomach pain.
  • Try limiting the amount of alcohol you drink while taking this medication.
  • Check your blood sugar regularly.
Learn more
More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
More about GlucovanceSide effectsAlternativesFDA package insert
Have you used Glucovance (metformin / glyburide)?
Worth itNot sureNot worth it