Compare Glucotrol vs. glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glucotrol XL
(glipizide)

Diabeta
(glyburide)

Lowers blood sugar. Glucotrol XL (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low, so you must always carry some form of sugar with you that can be readily used.Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.
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Coupons for Glucotrol
Best available price for 60 (5mg) tablets of glucotrol
Coupons for glyburide
Best available price for 60 (5mg) tablets of glyburide
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.29Glucotrol
Reviews for Glucotrol
50%
of people (All ages) say Glucotrol is worth it
32%
say it works well
19%
say it's a big hassle
332 reviews
Have you used Glucotrol XL (glipizide)?
Worth itNot sureNot worth it
Reviews for glyburide
45%
+5% better vs. Glucotrol
34%
-2% worse vs. Glucotrol
21%
+2% better vs. Glucotrol
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Side effects
Glucotrolglyburide
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Low blood sugar 3%
  • Constipation 3%
  • Nausea 3%
  • Headache 2%
More Glucotrol side effects »
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
How it works
Glucotrolglyburide
Glucotrol XL (glipizide) stimulates your body to release insulin and lower blood sugar.Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.
Type of medication
Glucotrolglyburide
Prescription onlyPrescription only
Available as
Glucotrolglyburide
  • Pill
  • Extended release pill
  • Pill
Used for
Glucotrolglyburide
Risk factors for serious side effects
Glucotrolglyburide
  • Skipping meals or having inconsistent meal times
  • Drinking alcohol
  • Using other blood sugar-lowering medicine
  • People age 60 or older
  • Those with kidney and/or liver problems
Detailed Glucotrol XL (glipizide) risks & warnings »
  • Over age 65
  • Kidney problems
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
Detailed Diabeta (glyburide) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
Glucotrolglyburide
  • Avoid drinking alcohol while taking Glucotrol XL (glipizide).
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
Food
Glucotrolglyburide
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
  • Eat well-balanced meals to avoid low blood sugar.
Kidneys and liver
Glucotrolglyburide
  • People with kidney and/or liver problems take a longer time to get rid of Glucotrol XL (glipizide) from their body. They are more sensitive to the effects of low blood sugar that include symptoms such as fast heartbeat, sweating, pale skin, shakiness, confusion and irritability. They need to make sure to carry with them some form of sugar such as hard candies or glucose tablets at all times while they are on this medicine.
  • Can be used in those with kidney problems.
  • Not ideal for elderly or those with poor kidney function.
Weight
Glucotrolglyburide
  • Can cause mild weight gain of 2 to 3 pounds on average.
  • Can cause weight gain, dizziness, or stomach upset.
  • Can cause weight gain (about 2 to 3 pounds).
Upsides and benefits
Glucotrolglyburide
  • Lowers A1c levels by 1-2%. (A1c is a test that measures your average blood sugars over the past 3 months).
  • Glucotrol XL (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Can be used in those with kidney problems.
  • Available as a generic form and is relatively cheap.
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
Downsides and risks
Glucotrolglyburide
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • While taking Glucotrol XL (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
  • Can cause mild weight gain of 2 to 3 pounds on average.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
Tips from our pharmacists for people taking the medication
Glucotrolglyburide
  • Take the medicine 30 minutes before eating, usually before your first big meal of the day.
  • Avoid drinking alcohol while taking Glucotrol XL (glipizide).
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
  • Check your blood sugar regularly.
  • Glucotrol XL (glipizide) can cause dizziness so avoid activities that require coordination until you know how your body can handle the medicine.
  • Check your blood sugar regularly.
  • Eat well-balanced meals to avoid low blood sugar.
  • Works best if you take it 30 minutes before first main meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
Learn more
More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Glucotrol XL (glipizide)?
Worth itNot sureNot worth it
More about glyburideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it