Compare Glucotrol vs. Humalog

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glucotrol (glipizide)

Prescription only

Humalog (Insulin Lispro)

Prescription only
Lowers blood sugar.

Glucotrol (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low so you must always carry some form of sugar with you that can be readily used.

4.3/ 7 average rating with 332 reviewsforGlucotrol
Lowers blood sugar.

Humalog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.

5.1/ 7 average rating with 280 reviewsforHumalog
Upsides
  • Lowers A1c levels by 1-2%.
  • Glucotrol (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Okay to use by people with kidney problems.
  • Available as a generic form and is relatively cheap.
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Humalog is a fast-acting insulin that provides sugar control after meals.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Downsides
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • While taking Glucotrol (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
  • Can cause mild weight gain of 2-3lb.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
  • You have to take insulin by injection.
  • You have to check your blood sugar multiple times every day, usually before each meal.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
Used for
Dosage forms
  • Pill
  • Extended release pill
  • Injection
Price
Lowest price near you
$9.99
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Lowest price near you
$529.81
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Reviews
332 
50%
think this treatment is worth it
32%
think this treatment works well
19%
think this treatment is a hassle

Have you used Glucotrol (glipizide)?

Leave a review
280 
64%
think this treatment is worth it
50%
think this treatment works well
16%
think this treatment is a hassle

Have you used Humalog (Insulin Lispro)?

Leave a review
Side effects
9possible side effects
  • Dizziness
    7%
  • Diarrhea
    5%
  • Nervousness
    4%
  • Tremor
    4%
  • Low blood sugar
    3%
  • Constipation
    3%
  • Passing gas
    3%
  • Nausea
    3%
  • Headache
    2%
See more detailed side effects
The Humalog (Insulin Lispro) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Low blood sugar

    Skipping meals or having inconsistent meal times

    ...and 4 more risk factors

  • Severe allergic reaction

    History of allergy to sulfa-containing medicine

  • Kidney and liver disease

    Those with kidney and/or liver disease

  • Breakdown of red blood cells

    People with G6PD deficiency

See more detailed risks and warnings
  • Life-threatening low blood sugar (Hypoglycemia)

    Insulin dose too high

    ...and 4 more risk factors

  • Complications due to low potassium

    Use of other medicine that lowers potassium

    ...and 1 more risk factors

See more detailed risks and warnings