Compare Glucotrol vs. Human insulin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glucotrol
(Glipizide)

Humulin
(Human Insulin)

Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.2696969696969695Glucotrol
Reviews for Glucotrol (Glipizide)
50%
of people say Glucotrol (Glipizide) is worth it
32%
say it works well
19%
say it's a big hassle
Reviews for Humulin (Human Insulin)
67%
+17% vs. Glucotrol (Glipizide)
46%
+14% vs. Glucotrol (Glipizide)
11%
+8% vs. Glucotrol (Glipizide)
Side effects
GlucotrolHuman insulin
  • Passing gas 2%
  • Dizziness 1%
  • Nervousness 1%
More Glucotrol side effects »

The Human insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human insulin side effects »
How it works
GlucotrolHuman insulin
Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.
Type of medication
GlucotrolHuman insulin
Anti-diabetic
Sulfonylurea
Prescription only
Anti-diabetic
Insulin
Prescription only
Available as
GlucotrolHuman insulin
  • Pill
  • Extended release
  • Injection
  • Inhaler
Used for (click to learn more)
GlucotrolHuman insulin
Risk factors for serious side effects
GlucotrolHuman insulin
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
    • History of sulfa allergies
    Detailed Glucotrol (Glipizide) risks & warnings »
          Detailed Humulin (Human Insulin) risks & warnings »
          Pregnancy category
          GlucotrolHuman insulin
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          • Avoid drinking alcohol.
          No specific alcohol-related info.
          Food
          • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
          • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
          • Eat regular, balanced meals to avoid low blood sugar.
          No specific food-related info.
          Kidneys and liver
          • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
          No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          • Can cause mild weight gain (2 to 3 pounds).
          • Can cause weight gain, dizziness, or stomach upset.
          • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
          Upsides and benefits
          GlucotrolHuman insulin
          • Oral blood sugar-lowering medicine.
          • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
          • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
          • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
          • One of the least expensive diabetes medicines.
          • Some types of this medication are available without a prescription.
          • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
          • Available in different combinations so that you can do one shot or multiple shots a day.
          Downsides and risks
          GlucotrolHuman insulin
          • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
          • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
          • Can cause mild weight gain (2 to 3 pounds).
          • Loses effectiveness over time or as your body stops making insulin.
          • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
          • Has to be taken exactly as directed or it can cause high or low blood sugar.
          • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
          Tips from our pharmacists for people taking the medication
          GlucotrolHuman insulin
          • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
          • Can cause weight gain, dizziness, or stomach upset.
          • Avoid drinking alcohol.
          • Eat regular, balanced meals to avoid low blood sugar.
          • Check your blood sugar regularly.
          • Change the location where you give yourself the shot every time.
          • Don't use if the liquid in the vial looks different than normal.
          • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
          • Take the medication exactly how your doctor tells you to.
          • Know the symptoms of low blood sugar.
          Learn more
          More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
          More about Human insulinSide effectsReviews & ratingsAlternativesFDA package insert