Compare Glucotrol vs. Lantus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glucotrol
(Glipizide)

Lantus
(Insulin Glargine)

Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.Lowers blood sugar. Lantus (Insulin Glargine) is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.29Glucotrol
Reviews for Glucotrol (Glipizide)
50%
of people (All ages) say Glucotrol (Glipizide) is worth it
32%
say it works well
19%
say it's a big hassle
332 reviews
Have you used Glucotrol (Glipizide)?
Worth itNot sureNot worth it
Reviews for Lantus (Insulin Glargine)
67%
+17% better vs. Glucotrol (Glipizide)
51%
+19% better vs. Glucotrol (Glipizide)
14%
+5% better vs. Glucotrol (Glipizide)
584 reviews
Have you used Lantus (Insulin Glargine)?
Worth itNot sureNot worth it
Side effects
GlucotrolLantus
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Drowsiness 2%
More Glucotrol side effects »
  • Ear, nose, or throat infection 22%
  • Infection 9%
  • Accidental injury 6%
  • Headache 6%
  • Ankle and leg swelling 20%
  • High blood pressure 20%
  • Sinus inflammation 19%
  • Flu 19%
  • Clouded eye lens 18%
  • Bronchitis 15%
More Lantus side effects »
How it works
GlucotrolLantus
Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Lantus (Insulin Glargine) is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.
Type of medication
GlucotrolLantus
Prescription only
Prescription only
Available as
GlucotrolLantus
  • Pill
  • Extended release
  • Injection
Used for
GlucotrolLantus
Risk factors for serious side effects
GlucotrolLantus
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
    • History of sulfa allergies
    Detailed Glucotrol (Glipizide) risks & warnings »
    • Insulin dose too high
    • Use of other blood sugar lowering medicines
    • Poor injection techniques
    • Unstable kidney functions
    • Unstable liver functions
    • Use of other medicine that lowers potassium
    • Current electrolyte imbalance
      Detailed Lantus (Insulin Glargine) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Alcohol
      GlucotrolLantus
      • Avoid drinking alcohol.
      No alcohol related info.
      Food
      GlucotrolLantus
      • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
      • Eat regular, balanced meals to avoid low blood sugar.
      No food related info.
      Kidneys and liver
      GlucotrolLantus
      • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      Weight
      GlucotrolLantus
      • Can cause mild weight gain (2 to 3 pounds).
      • Can cause weight gain, dizziness, or stomach upset.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Can cause weight gain and low blood sugar.
      Upsides and benefits
      GlucotrolLantus
      • Oral blood sugar-lowering medicine.
      • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
      • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
      • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
      • One of the least expensive diabetes medicines.
      • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
      • Lantus is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
      • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
      • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
      • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
      Downsides and risks
      GlucotrolLantus
      • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
      • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
      • Can cause mild weight gain (2 to 3 pounds).
      • Loses effectiveness over time or as your body stops making insulin.
      • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
      • You have to take insulin by injection.
      • You have to check your blood sugar every day.
      • Likely to cause moderate weight gain (around 4 to 6 pounds).
      • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
      Tips from our pharmacists for people taking the medication
      GlucotrolLantus
      • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
      • Can cause weight gain, dizziness, or stomach upset.
      • Avoid drinking alcohol.
      • Eat regular, balanced meals to avoid low blood sugar.
      • Check your blood sugar regularly.
      • Long-acting insulin good for baseline blood sugar control.
      • Works in 1 hour and lasts about 24 hours.
      • Can cause weight gain and low blood sugar.
      • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
      • Always have a good source of sugar nearby for low blood sugar episodes.
      • Take it at the same time every day.
      • Make sure you understand how to give yourself the injections.
      • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
      • Check your blood sugar levels every day.
      Learn more
      More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Glucotrol (Glipizide)?
      Worth itNot sureNot worth it
      More about LantusSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Lantus (Insulin Glargine)?
      Worth itNot sureNot worth it