Compare Glucotrol vs. Prandin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glucotrol
(glipizide)

Prandin
(repaglinide)

Lowers blood sugar. Glucotrol (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low so you must always carry some form of sugar with you that can be readily used.Lowers blood sugar. Prandin (repaglinide) works quickly to lower blood sugar, especially during mealtimes. However, it can cause hypoglycemia (low blood sugar) if you are not consistent with your diet and exercise schedule.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.29Glucotrol
Reviews for Glucotrol
50%
of people (All ages) say Glucotrol is worth it
32%
say it works well
19%
say it's a big hassle
332 reviews
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it

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Have you used Prandin (repaglinide)?
Worth itNot sureNot worth it
Side effects
GlucotrolPrandin
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Low blood sugar 3%
  • Constipation 3%
  • Nausea 3%
  • Headache 2%
More Glucotrol side effects »
  • Common cold 8%
  • Low blood sugar 24%
  • Headache 1%
  • Joint pain 3%
  • Sinus inflammation 4%
  • Diarrhea 3%
  • Back pain 1%
  • Swelling in arms and legs 5%
  • Heart failure 4%
More Prandin side effects »
How it works
GlucotrolPrandin
Glucotrol (glipizide) stimulates your body to release insulin and lower blood sugar.Prandin (repaglinide) stimulates your body to produce more insulin.
Type of medication
GlucotrolPrandin
Prescription onlyPrescription only
Available as
GlucotrolPrandin
  • Pill
  • Extended release pill
  • Pill
Used for
GlucotrolPrandin
Risk factors for serious side effects
GlucotrolPrandin
  • Skipping meals or having inconsistent meal times
  • Drinking alcohol
  • Using other blood sugar-lowering medicine
  • People age 60 or older
  • Those with kidney and/or liver problems
Detailed Glucotrol (glipizide) risks & warnings »
  • Alcoholism
  • Changes in meal pattern
  • Changes in exercise
  • Insulin
  • Other antidiabetic medications
Detailed Prandin (repaglinide) risks & warnings »
Pregnancy
Alcohol
GlucotrolPrandin
  • Avoid drinking alcohol while taking Glucotrol (glipizide).
No alcohol related info.
Food
GlucotrolPrandin
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
  • If you skip a meal, skip your dose to prevent hypoglycemia (low blood sugar).
  • Quickly and effectively lowers blood sugar during meal times.
Kidneys and liver
GlucotrolPrandin
No kidneys and liver related info.
  • Not a good choice if you have poor kidney function, liver problems, or younger than 18 years old.
Weight
GlucotrolPrandin
  • Can cause mild weight gain of 2-3lb.
  • May cause some weight gain.
Upsides and benefits
GlucotrolPrandin
  • Lowers A1c levels by 1-2%.
  • Glucotrol (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Okay to use by people with kidney problems.
  • Available as a generic form and is relatively cheap.
  • Quickly and effectively lowers blood sugar during meal times.
  • Less likely to cause hypoglycemia (low blood sugar) than Starlix (nateglinide).
  • Good first-choice if you cannot tolerate metformin or add-on therapy if your blood sugars are not controlled on metformin alone.
Downsides and risks
GlucotrolPrandin
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • While taking Glucotrol (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
  • Can cause mild weight gain of 2-3lb.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
  • May cause some weight gain.
  • May cause hypoglycemia (low blood sugar).
  • Can frequently interfere with how other medicines work.
  • Not a good choice if you have poor kidney function, liver problems, or younger than 18 years old.
Tips from our pharmacists for people taking the medication
GlucotrolPrandin
  • Take the medicine 30 minutes before eating, usually before your first big meal of the day.
  • Avoid drinking alcohol while taking Glucotrol (glipizide).
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
  • Check your blood sugar regularly.
  • Glucotrol (glipizide) can cause dizziness so avoid activities that require coordination until you know how your body can handle the medicine.
  • Works quickly to lower blood sugar so should be taken 15 to 30 minutes before a meal.
  • If you skip a meal, skip your dose to prevent hypoglycemia (low blood sugar).
  • Maintain a regular diet and exercise schedule while on this medicine to prevent fluctuations in your blood sugar.
Learn more
More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Glucotrol (glipizide)?
Worth itNot sureNot worth it
More about PrandinSide effectsAlternativesFDA package insert
Have you used Prandin (repaglinide)?
Worth itNot sureNot worth it