Compare Glucovance vs. Glyburide

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glucovance
(Metformin / Glyburide)

Diabeta
(Glyburide)

Lowers blood sugar. Glucovance (Metformin / Glyburide) is a very effective combo medication to lower blood sugar when taking one medication alone isn't enough. It's likely to cause diarrhea for the first few weeks, and you can’t drink much alcohol.Lowers blood sugar. Glyburide is a very effective oral blood sugar-lowering medicine, but has more side effects and restrictions compared to other medicines in this class (sulfonylureas).
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Reviews & ratings
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Reviews for Diabeta (Glyburide)
46%
+46% vs. Glucovance (Metformin / Glyburide)
33%
+33% vs. Glucovance (Metformin / Glyburide)
20%
20% vs. Glucovance (Metformin / Glyburide)
Side effects
GlucovanceGlyburide
  • Low blood sugar 35%
  • Gi side effects 14%
  • Diarrhea 11%
  • Abdominal pain 3%
  • Upper respiratory infection 3%
  • Nausea/vomiting 2%
  • Dizziness 2%
More Glucovance side effects »

The Glyburide FDA package insert doesn’t have numbers about how common side effects are.

More about Glyburide side effects »
How it works
GlucovanceGlyburide
Glucovance (Metformin / Glyburide) is a combination medication for diabetes. Metformin lowers sugar (glucose) production in your body, decreases the amount of glucose getting into your blood, and makes your body more sensitive to insulin. Glyburide helps your body make more insulin to lower blood sugar.Glyburide is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.
Type of medication
GlucovanceGlyburide
Anti-diabetic
Biguanide
Sulfonylurea
Prescription only
Anti-diabetic
Sulfonylurea
Prescription only
Available as
GlucovanceGlyburide
  • Pill
  • Pill
Used for (click to learn more)
GlucovanceGlyburide
Risk factors for serious side effects
GlucovanceGlyburide
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
  • Alcohol use
    • Elderly
    • Use of other blood sugar lowering medicines
    • Alcohol use
    • Intense physical activity
    • History of sulfa reactions
      Detailed Glucovance (Metformin / Glyburide) risks & warnings »
        • Elderly
        • Use of other blood sugar lowering medicines
        • Alcohol
        • Intense physical activity
        • History of sulfa allergies
        Detailed Diabeta (Glyburide) risks & warnings »
        Pregnancy category
        GlucovanceGlyburide
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
        • Try limiting the amount of alcohol you drink while taking this medication.
        • Avoid drinking alcohol.
        Food
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • Eat regular, balanced meals to avoid low blood sugar.
        Kidneys and liver
        • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
        • Glucovance (Metformin / Glyburide) can cause lactic acidosis, a rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucovance (Metformin / Glyburide). It may not be a good choice for people with kidney problems. Glucovance (Metformin / Glyburide) should be stopped 48 hours before and/or after surgery or procedure that'll use contrast dye.
        • Not a good choice for people with kidney problems because it's processed by the kidneys.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        • Can cause some weight gain.
        • Can cause mild weight gain (2 to 3 pounds).
        • Can cause weight gain, dizziness, or stomach upset.
        Upsides and benefits
        GlucovanceGlyburide
        • A combination medication that lowers your blood sugar in multiple ways. It's used by people who need tighter control of their blood sugar.
        • Can greatly lower A1c levels. The Hemoglobin A1c test measures your average blood sugar levels over the last few months.
        • Prevents harmful effects of high blood sugar levels on your organs and blood vessels.
        • Also lowers certain lipid (fat and cholesterol) levels.
        • Oral blood sugar-lowering medicine.
        • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • One of the least expensive diabetes medicines.
        Downsides and risks
        GlucovanceGlyburide
        • There's a higher risk of low blood sugar episodes than with other kinds of oral diabetes medications.
        • Most people will have nausea, stomach upset, or diarrhea in the first few weeks. You can lower these symptoms if you take it on a full stomach.
        • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
        • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
        • Can cause some weight gain.
        • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
        • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
        • Can cause mild weight gain (2 to 3 pounds).
        • Not preferred for people 65 years or older since it can cause prolonged low blood sugar (more than 12 hours).
        • Not a good choice for people with kidney problems because it's processed by the kidneys.
        • Loses effectiveness over time or as your body stops making insulin.
        Tips from our pharmacists for people taking the medication
        GlucovanceGlyburide
        • Can cause upset stomach, nausea, and diarrhea in the first couple of weeks.
        • Tell your doctor about any deep or rapid breathing, persistent nausea, vomiting, or stomach pain.
        • Try limiting the amount of alcohol you drink while taking this medication.
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • Check your blood sugar regularly.
        • Can cause weight gain, dizziness, or stomach upset.
        • Avoid drinking alcohol.
        • Eat regular, balanced meals to avoid low blood sugar.
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • Check your blood sugar regularly.
        Learn more
        More about GlucovanceSide effectsAlternativesFDA package insert
        More about GlyburideSide effectsReviews & ratingsAlternativesFDA package insert