Compare Glucovance vs. Humalog

Head-to-head comparisons of medication uses, side effects, ratings, and more.

glyburide / metformin

Humalog
(insulin lispro)

Lowers blood sugar. Glyburide / Metformin is an effective combination medicine for lowering blood sugar, but it is likely to cause diarrhea in the first few weeks.Lowers blood sugar. Humalog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
Reviews & ratings
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Have you used Glyburide / Metformin?
Worth itNot sureNot worth it
Reviews for Humalog
64%
-64% worse vs. Glucovance
50%
-50% worse vs. Glucovance
16%
+16% better vs. Glucovance
280 reviews
Have you used Humalog (insulin lispro)?
Worth itNot sureNot worth it
Side effects
GlucovanceHumalog
  • Upper respiratory infection 3%
  • Diarrhea 11%
  • Nausea/vomiting 2%
  • Stomach pain 3%
  • Dizziness 2%
  • Gastrointestinal side effects (diarrhea, nausea/vomiting, and stomach pain) 8%
  • Low blood sugar 8%
More Glucovance side effects »
  • Flu syndrome 35%
  • Sore throat 33%
  • Headache 30%
  • Inflammation inside the nose 25%
  • Pain 20%
  • Cough increased 17%
  • Infection 14%
  • Accidental injury 9%
  • Diarrhea 9%
  • Muscle weakness 7%
More Humalog side effects »
How it works
GlucovanceHumalog
Glyburide / Metformin combines 2 prescription medicines (glyburide and metformin) into 1 pill to help treat diabetes. Glyburide stimulates your body to release insulin to lower blood sugar. Metformin helps your body use its own insulin more effectively as well as lowers the amount of sugar your body naturally makes and absorbs from food.Humalog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.
Type of medication
GlucovanceHumalog
Prescription onlyPrescription only
Available as
GlucovanceHumalog
  • Pill
  • Injection
Used for
GlucovanceHumalog
Risk factors for serious side effects
GlucovanceHumalog
  • History of kidney problems
  • History of liver problems
  • Those with congestive heart failure
  • Using contrast dye for procedures
  • Undergoing surgery
Detailed Glyburide / Metformin risks & warnings »
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Humalog (insulin lispro) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
GlucovanceHumalog
  • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
  • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
No alcohol related info.
Food
GlucovanceHumalog
No food related info.
  • Short-acting insulin good for blood sugar control around meal times.
Kidneys and liver
GlucovanceHumalog
  • Not a good treatment option for those with kidney and/or liver problems.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Weight
GlucovanceHumalog
  • Can cause some weight gain.
  • Can cause weight gain and low blood sugar.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
Upsides and benefits
GlucovanceHumalog
  • Glyburide / Metformin effectively lowers blood sugar levels more so than if each of the individual medicines it contains are taken alone.
  • Protects your organs and blood vessels from the harmful effects of high blood sugar levels.
  • Can potentially lower your "bad cholesterol" levels.
  • Glyburide / Metformin is available in a generic form and is cheaper than many other combination diabetes medicines.
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Humalog is a fast-acting insulin that provides sugar control after meals.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Downsides and risks
GlucovanceHumalog
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • Glyburide / Metformin is likely to cause nausea, stomach upset, or diarrhea in the first few weeks.
  • Not a good treatment option for those with kidney and/or liver problems.
  • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
  • Can cause some weight gain.
  • You have to take insulin by injection.
  • You have to check your blood sugar multiple times every day, usually before each meal.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
Tips from our pharmacists for people taking the medication
GlucovanceHumalog
  • Check your blood sugar regularly.
  • Wear sunscreen and appropriate clothing to protect yourself from the sun.
  • Take the medicine with meals to prevent an upset stomach.
  • Tell your doctor right away if you experience rapid breathing, ongoing nausea, vomiting, or stomach pain.
  • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
  • Short-acting insulin good for blood sugar control around meal times.
  • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
  • Can cause weight gain and low blood sugar.
  • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
  • Always have a good source of sugar nearby for low blood sugar episodes.
  • Make sure you understand how to give yourself the injections.
  • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
  • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
  • Check your blood sugar levels every day.
Learn more
More about GlucovanceSide effectsAlternativesFDA package insert
Have you used Glyburide / Metformin?
Worth itNot sureNot worth it
More about HumalogSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Humalog (insulin lispro)?
Worth itNot sureNot worth it