Compare Glucovance vs. Human insulin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glucovance
(Metformin / Glyburide)

Humulin
(Human Insulin)

Lowers blood sugar. Glucovance (Metformin / Glyburide) is a very effective combo medication to lower blood sugar when taking one medication alone isn't enough. It's likely to cause diarrhea for the first few weeks, and you can’t drink much alcohol.Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.
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Reviews & ratings
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Reviews for Humulin (Human Insulin)
67%
+67% vs. Glucovance (Metformin / Glyburide)
46%
+46% vs. Glucovance (Metformin / Glyburide)
11%
11% vs. Glucovance (Metformin / Glyburide)
Side effects
GlucovanceHuman insulin
  • Low blood sugar 35%
  • Gi side effects 14%
  • Diarrhea 11%
  • Abdominal pain 3%
  • Upper respiratory infection 3%
  • Nausea/vomiting 2%
  • Dizziness 2%
More Glucovance side effects »

The Human insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human insulin side effects »
How it works
GlucovanceHuman insulin
Glucovance (Metformin / Glyburide) is a combination medication for diabetes. Metformin lowers sugar (glucose) production in your body, decreases the amount of glucose getting into your blood, and makes your body more sensitive to insulin. Glyburide helps your body make more insulin to lower blood sugar.Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.
Type of medication
GlucovanceHuman insulin
Anti-diabetic
Biguanide
Sulfonylurea
Prescription only
Anti-diabetic
Insulin
Prescription only
Available as
GlucovanceHuman insulin
  • Pill
  • Injection
  • Inhaler
Used for (click to learn more)
GlucovanceHuman insulin
Risk factors for serious side effects
GlucovanceHuman insulin
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
  • Alcohol use
    • Elderly
    • Use of other blood sugar lowering medicines
    • Alcohol use
    • Intense physical activity
    • History of sulfa reactions
      Detailed Glucovance (Metformin / Glyburide) risks & warnings »
            Detailed Humulin (Human Insulin) risks & warnings »
            Pregnancy category
            GlucovanceHuman insulin
            BFDA pregnancy category (Probably safe)

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            See the FDA package insert
            BFDA pregnancy category (Probably safe)

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            See the FDA package insert
            Alcohol
            • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
            • Try limiting the amount of alcohol you drink while taking this medication.
            No specific alcohol-related info.
            Food
            • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
            No specific food-related info.
            Kidneys and liver
            • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
            • Glucovance (Metformin / Glyburide) can cause lactic acidosis, a rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucovance (Metformin / Glyburide). It may not be a good choice for people with kidney problems. Glucovance (Metformin / Glyburide) should be stopped 48 hours before and/or after surgery or procedure that'll use contrast dye.
            No specific kidneys and liver-related info.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.No specific sleep-related info.
            Weight
            • Can cause some weight gain.
            • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
            Upsides and benefits
            GlucovanceHuman insulin
            • A combination medication that lowers your blood sugar in multiple ways. It's used by people who need tighter control of their blood sugar.
            • Can greatly lower A1c levels. The Hemoglobin A1c test measures your average blood sugar levels over the last few months.
            • Prevents harmful effects of high blood sugar levels on your organs and blood vessels.
            • Also lowers certain lipid (fat and cholesterol) levels.
            • Some types of this medication are available without a prescription.
            • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
            • Available in different combinations so that you can do one shot or multiple shots a day.
            Downsides and risks
            GlucovanceHuman insulin
            • There's a higher risk of low blood sugar episodes than with other kinds of oral diabetes medications.
            • Most people will have nausea, stomach upset, or diarrhea in the first few weeks. You can lower these symptoms if you take it on a full stomach.
            • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
            • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
            • Can cause some weight gain.
            • Has to be taken exactly as directed or it can cause high or low blood sugar.
            • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
            Tips from our pharmacists for people taking the medication
            GlucovanceHuman insulin
            • Can cause upset stomach, nausea, and diarrhea in the first couple of weeks.
            • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
            • Tell your doctor about any deep or rapid breathing, persistent nausea, vomiting, or stomach pain.
            • Try limiting the amount of alcohol you drink while taking this medication.
            • Check your blood sugar regularly.
            • Change the location where you give yourself the shot every time.
            • Don't use if the liquid in the vial looks different than normal.
            • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
            • Take the medication exactly how your doctor tells you to.
            • Know the symptoms of low blood sugar.
            Learn more
            More about GlucovanceSide effectsAlternativesFDA package insert
            More about Human insulinSide effectsReviews & ratingsAlternativesFDA package insert