Compare Glucovance vs. Human Insulin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

glyburide / metformin

Humulin
(human insulin)

Lowers blood sugar. Glyburide / Metformin is an effective combination medicine for lowering blood sugar, but it is likely to cause diarrhea in the first few weeks.Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.
Reviews & ratings
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Have you used Glyburide / Metformin?
Worth itNot sureNot worth it
Reviews for Human Insulin
67%
-67% worse vs. Glucovance
46%
-46% worse vs. Glucovance
11%
+11% better vs. Glucovance
Have you used Humulin (human insulin)?
Worth itNot sureNot worth it
Side effects
GlucovanceHuman Insulin
  • Upper respiratory infection 3%
  • Diarrhea 11%
  • Nausea/vomiting 2%
  • Stomach pain 3%
  • Dizziness 2%
  • Gastrointestinal side effects (diarrhea, nausea/vomiting, and stomach pain) 8%
  • Low blood sugar 8%
More Glucovance side effects »

The Human Insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human Insulin side effects »
How it works
GlucovanceHuman Insulin
Glyburide / Metformin combines 2 prescription medicines (glyburide and metformin) into 1 pill to help treat diabetes. Glyburide stimulates your body to release insulin to lower blood sugar. Metformin helps your body use its own insulin more effectively as well as lowers the amount of sugar your body naturally makes and absorbs from food.Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.
Type of medication
GlucovanceHuman Insulin
Prescription onlyPrescription only
Available as
GlucovanceHuman Insulin
  • Pill
  • Injection
  • Inhaler
Used for
GlucovanceHuman Insulin
Risk factors for serious side effects
GlucovanceHuman Insulin
  • History of kidney problems
  • History of liver problems
  • Those with congestive heart failure
  • Using contrast dye for procedures
  • Undergoing surgery
Detailed Glyburide / Metformin risks & warnings »
    Detailed Humulin (human insulin) risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Alcohol
    GlucovanceHuman Insulin
    • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
    • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
    No alcohol related info.
    Kidneys and liver
    GlucovanceHuman Insulin
    • Not a good treatment option for those with kidney and/or liver problems.
    No kidneys and liver related info.
    Weight
    GlucovanceHuman Insulin
    • Can cause some weight gain.
    • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
    Upsides and benefits
    GlucovanceHuman Insulin
    • Glyburide / Metformin effectively lowers blood sugar levels more so than if each of the individual medicines it contains are taken alone.
    • Protects your organs and blood vessels from the harmful effects of high blood sugar levels.
    • Can potentially lower your "bad cholesterol" levels.
    • Glyburide / Metformin is available in a generic form and is cheaper than many other combination diabetes medicines.
    • Some types of this medication are available without a prescription.
    • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
    • Available in different combinations so that you can do one shot or multiple shots a day.
    Downsides and risks
    GlucovanceHuman Insulin
    • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
    • Glyburide / Metformin is likely to cause nausea, stomach upset, or diarrhea in the first few weeks.
    • Not a good treatment option for those with kidney and/or liver problems.
    • Drinking large amounts of or frequently using alcohol while taking Glyburide / Metformin can cause harm to your body.
    • Can cause some weight gain.
    • Has to be taken exactly as directed or it can cause high or low blood sugar.
    • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
    Tips from our pharmacists for people taking the medication
    GlucovanceHuman Insulin
    • Check your blood sugar regularly.
    • Wear sunscreen and appropriate clothing to protect yourself from the sun.
    • Take the medicine with meals to prevent an upset stomach.
    • Tell your doctor right away if you experience rapid breathing, ongoing nausea, vomiting, or stomach pain.
    • Limit the amount of alcohol you drink while taking Glyburide / Metformin.
    • Change the location where you give yourself the shot every time.
    • Don't use if the liquid in the vial looks different than normal.
    • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
    • Take the medication exactly how your doctor tells you to.
    • Know the symptoms of low blood sugar.
    Learn more
    More about GlucovanceSide effectsAlternativesFDA package insert
    Have you used Glyburide / Metformin?
    Worth itNot sureNot worth it
    More about Human InsulinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Humulin (human insulin)?
    Worth itNot sureNot worth it