Compare Glucovance vs. Novolog

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Glucovance
(Metformin / Glyburide)

Novolog
(Insulin Aspart)

Lowers blood sugar. Glucovance (Metformin / Glyburide) is a very effective combo medication to lower blood sugar when taking one medication alone isn't enough. It's likely to cause diarrhea for the first few weeks, and you can’t drink much alcohol.Lowers blood sugar. Novolog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
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Reviews & ratings
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Reviews for Novolog (Insulin Aspart)
58%
+58% vs. Glucovance (Metformin / Glyburide)
46%
+46% vs. Glucovance (Metformin / Glyburide)
18%
18% vs. Glucovance (Metformin / Glyburide)
Side effects
GlucovanceNovolog
  • Low blood sugar 35%
  • Gi side effects 14%
  • Diarrhea 11%
  • Abdominal pain 3%
  • Upper respiratory infection 3%
  • Nausea/vomiting 2%
  • Dizziness 2%
More Glucovance side effects »

The Novolog FDA package insert doesn’t have numbers about how common side effects are.

More about Novolog side effects »
How it works
GlucovanceNovolog
Glucovance (Metformin / Glyburide) is a combination medication for diabetes. Metformin lowers sugar (glucose) production in your body, decreases the amount of glucose getting into your blood, and makes your body more sensitive to insulin. Glyburide helps your body make more insulin to lower blood sugar.Novolog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.
Type of medication
GlucovanceNovolog
Anti-diabetic
Biguanide
Sulfonylurea
Prescription only
Anti-diabetic
Insulin
Prescription only
Available as
GlucovanceNovolog
  • Pill
  • Injection
Used for (click to learn more)
GlucovanceNovolog
Risk factors for serious side effects
GlucovanceNovolog
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
  • Alcohol use
    • Elderly
    • Use of other blood sugar lowering medicines
    • Alcohol use
    • Intense physical activity
    • History of sulfa reactions
      Detailed Glucovance (Metformin / Glyburide) risks & warnings »
      • Insulin dose too high
      • Use of other blood sugar lowering medicines
      • Poor injection techniques
      • Unstable kidney functions
      • Unstable liver functions
      • Use of other medicine that lowers potassium
      • Current electrolyte imbalance
        Detailed Novolog (Insulin Aspart) risks & warnings »
        Pregnancy category
        GlucovanceNovolog
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        Alcohol
        • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
        • Try limiting the amount of alcohol you drink while taking this medication.
        No specific alcohol-related info.
        Food
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • You have to check your blood sugar multiple times every day, usually before each meal.
        • Novolog is a fast-acting insulin that provides sugar control after meals.
        • Short-acting insulin good for blood sugar control around meal times.
        • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
        Kidneys and liver
        • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
        • Glucovance (Metformin / Glyburide) can cause lactic acidosis, a rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Glucovance (Metformin / Glyburide). It may not be a good choice for people with kidney problems. Glucovance (Metformin / Glyburide) should be stopped 48 hours before and/or after surgery or procedure that'll use contrast dye.
        • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        • Can cause some weight gain.
        • Likely to cause moderate weight gain (around 4 to 6 pounds).
        • Can cause weight gain and low blood sugar.
        Upsides and benefits
        GlucovanceNovolog
        • A combination medication that lowers your blood sugar in multiple ways. It's used by people who need tighter control of their blood sugar.
        • Can greatly lower A1c levels. The Hemoglobin A1c test measures your average blood sugar levels over the last few months.
        • Prevents harmful effects of high blood sugar levels on your organs and blood vessels.
        • Also lowers certain lipid (fat and cholesterol) levels.
        • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
        • Novolog is a fast-acting insulin that provides sugar control after meals.
        • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
        • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
        • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
        Downsides and risks
        GlucovanceNovolog
        • There's a higher risk of low blood sugar episodes than with other kinds of oral diabetes medications.
        • Most people will have nausea, stomach upset, or diarrhea in the first few weeks. You can lower these symptoms if you take it on a full stomach.
        • People with poor kidney function can't use Glucovance (Metformin / Glyburide).
        • Can't drink excessive amounts of alcohol or “binge drink” while taking this.
        • Can cause some weight gain.
        • You have to take insulin by injection.
        • You have to check your blood sugar multiple times every day, usually before each meal.
        • Likely to cause moderate weight gain (around 4 to 6 pounds).
        • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
        Tips from our pharmacists for people taking the medication
        GlucovanceNovolog
        • Can cause upset stomach, nausea, and diarrhea in the first couple of weeks.
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • Tell your doctor about any deep or rapid breathing, persistent nausea, vomiting, or stomach pain.
        • Try limiting the amount of alcohol you drink while taking this medication.
        • Check your blood sugar regularly.
        • Short-acting insulin good for blood sugar control around meal times.
        • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
        • Can cause weight gain and low blood sugar.
        • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
        • Always have a good source of sugar nearby for low blood sugar episodes.
        • Make sure you understand how to give yourself the injections.
        • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
        • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
        • Check your blood sugar levels every day.
        Learn more
        More about GlucovanceSide effectsAlternativesFDA package insert
        More about NovologSide effectsReviews & ratingsAlternativesFDA package insert