Compare glyburide vs. Byetta
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.
Byetta (Exenatide) can lower your blood sugars in addition to metformin. It does not increase your appetite unlike some other anti-diabetics, but must be given by injection and usually causes upset stomach.
- Available as an oral tablet.
- Lowers your A1c (average blood sugar over time) up to 2%.
- Available in generic version.
- Available in single pill combination with other anti-diabetic medicines.
- Can lower your A1c (average blood sugar over time) by 1%.
- Not as likely to cause very low blood sugar as glyburine or insulin.
- Does not increase your appetite like other anti-diabetic medicines.
- Pen is dialed to a single dose for easy injections.
- More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
- You will have to check your blood sugar often when you first start taking it.
- Can cause weight gain (about 2 to 3 pounds).
- Not ideal for elderly or those with poor kidney function.
- May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
- Byetta (Exenatide) must be injected twice a day. Other medicines like it can be injected once daily or even weekly.
- It commonly causes nausea, vomiting, diarrhea, constipation, or indigestion.
- Can affect how well your antibiotics and birth control pills work. Take them no sooner than one hour after your injections.
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- Upset stomach3%
- Low blood sugar
- Over age 65
- Kidney problems
- Use of other blood sugar lowering medicines
- Intense physical activity
- Severe allergic reactions
- History of sulfa allergies
- Loss of medication effectiveness
- Kidney problems
- Severe renal impairment
- End-stage renal disease
- Serious stomach problems
- Severe gastrointestinal disease
- Low blood sugar (hypoglycemia)