Compare Glyburide vs. Byetta

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta
(glyburide)

Byetta
(exenatide)

Lowers blood sugar. Glyburide is a very effective oral blood sugar-lowering medicine, but has more side effects and restrictions compared to other medicines in this class (sulfonylureas).Lowers your blood sugar. Byetta (Exenatide) helps lower blood sugar for people with diabetes and causes weight loss, but it has to be given by injection and many people have upset stomach.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.42Glyburide
Reviews for Diabeta (glyburide)
45%
of people (All ages) say Diabeta (glyburide) is worth it
34%
say it works well
21%
say it's a big hassle
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Reviews for Byetta (exenatide)
Not enough review data. Review it!
+5% better vs. Diabeta (glyburide)
Not enough review data. Review it!
+16% better vs. Diabeta (glyburide)
Not enough review data. Review it!
+21% better vs. Diabeta (glyburide)
Have you used Byetta (exenatide)?
Worth itNot sureNot worth it
Side effects
GlyburideByetta
  • Gastrointestinal disturbances 2%
  • Allergic skin reactions 2%
More Glyburide side effects »
  • Low blood sugar 6%
  • Nausea 26%
  • Vomiting 14%
  • Diarrhea 10%
  • Headache 10%
  • Constipation 8%
  • Dizziness 3%
More Byetta side effects »
How it works
GlyburideByetta
Glyburide is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Byetta (Exenatide) is a medication for diabetes. It stimulates your body to produce and release more insulin, lower the sugar hormone (glucagon), and slow down digestion.
Type of medication
GlyburideByetta
Prescription only
Prescription only
Available as
GlyburideByetta
  • Pill
  • Injection
Used for
GlyburideByetta
Risk factors for serious side effects
GlyburideByetta
  • Elderly
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
  • History of sulfa allergies
Detailed Diabeta (glyburide) risks & warnings »
  • Severe renal impairment
  • End-stage renal disease
  • Severe gastrointestinal disease
  • Gastroparesis
Detailed Byetta (exenatide) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
GlyburideByetta
No interactions related info.
  • Because Byetta (Exenatide) can interact with antibiotics and birth control pills, you can't take it until one hour after these medications.
Alcohol
GlyburideByetta
  • Avoid drinking alcohol.
No alcohol related info.
Food
GlyburideByetta
  • Eat regular, balanced meals to avoid low blood sugar.
  • Eat regular, balanced meals to avoid low blood sugar.
Kidneys and liver
GlyburideByetta
  • Not a good choice for people with kidney problems because it's processed by the kidneys.
  • If you have severe kidney or liver problems, you should not take Byetta (Exenatide). Talk to your doctor about testing your kidneys before starting Byetta (Exenatide). People taking medications that are damaging to kidneys such as ACE inhibitors, NSAIDs or diuretics in addition to Byetta (Exenatide) may notice nausea, vomiting, or diarrhea.
Pain
GlyburideByetta
No pain related info.
  • Using Byetta (Exenatide) has been associated with stomach pain, nausea, vomiting and diarrhea. If you have severe gastrointestinal disease such as Crohn’s Disease or Ulcerative Colitis, you should talk to your doctor about using a different medication for diabetes. You should not use Byetta (Exenatide) if you have gastroparesis, a condition that causes slow or irregular digestion. Gastroparesis can be common for people that have had uncontrolled diabetes for a while.
Weight
GlyburideByetta
  • Can cause mild weight gain (2 to 3 pounds).
  • Can cause weight gain, dizziness, or stomach upset.
No weight related info.
Upsides and benefits
GlyburideByetta
  • Oral blood sugar-lowering medicine.
  • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • One of the least expensive diabetes medicines.
  • Lowers A1c levels by 1% (A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs.
  • Has a lower chance of causing low blood sugar than medications like glyburide or insulin.
  • Can lower your appetite by making you feel full. Some people also lose weight when taking Byetta (Exenatide).
  • Byetta (Exenatide) is not a replacement for diabetes pills, but you may be able to use it alone without the need for pills.
  • The injectable “pen” has easy to use doses which you may find more convenient than other types of injections.
Downsides and risks
GlyburideByetta
  • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
  • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
  • Can cause mild weight gain (2 to 3 pounds).
  • Not preferred for people 65 years or older since it can cause prolonged low blood sugar (more than 12 hours).
  • Not a good choice for people with kidney problems because it's processed by the kidneys.
  • Loses effectiveness over time or as your body stops making insulin.
  • Only lowers A1c levels by 1%, which may not be enough to get your blood sugar in the safe range.
  • Byetta (Exenatide) must be injected twice a day.
  • Up to 40% of people taking Byetta (Exenatide) have upset stomach and side effects like nausea, vomiting, diarrhea, constipation, or indigestion.
  • Because Byetta (Exenatide) can interact with antibiotics and birth control pills, you can't take it until one hour after these medications.
  • Other diabetes medications work as well and are cheaper.
Tips from our pharmacists for people taking the medication
GlyburideByetta
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Avoid drinking alcohol.
  • Eat regular, balanced meals to avoid low blood sugar.
  • Check your blood sugar regularly.
  • Store in the refrigerator until opening. Do not freeze.
  • Give injections in your belly, thighs, or upper arm within an hour of your two main meals of the day (separate doses by 6 or more hours).
  • Change the needle and prime the pen every time you inject.
  • It’s not safe to share this medication with other people, even if you change the needle.
  • Don’t mix with insulin; give separate injections. Can be given at the same time as insulin, but in different injection areas.
  • Eat regular, balanced meals to avoid low blood sugar.
  • It's best to check your blood sugar at least once a day using a home blood sugar monitor to make sure your medication is working and is safe. Some people may need to test more often, ask your doctor.
Learn more
More about GlyburideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
More about ByettaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Byetta (exenatide)?
Worth itNot sureNot worth it