Compare glyburide vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta
(glyburide)

Glucotrol XL
(glipizide)

Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.Lowers blood sugar. Glucotrol XL (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low, so you must always carry some form of sugar with you that can be readily used.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.42glyburide
Reviews for glyburide
45%
of people (All ages) say glyburide is worth it
34%
say it works well
21%
say it's a big hassle
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Reviews for Glucotrol
50%
-5% worse vs. glyburide
32%
+2% better vs. glyburide
19%
-2% worse vs. glyburide
332 reviews
Have you used Glucotrol XL (glipizide)?
Worth itNot sureNot worth it
Side effects
glyburideGlucotrol
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
  • Dizziness 1%
  • Diarrhea 5%
  • Nervousness 1%
  • Tremor 4%
  • Passing gas 2%
  • Low blood sugar 3%
  • Constipation 3%
  • Nausea 3%
  • Headache 2%
More Glucotrol side effects »
How it works
glyburideGlucotrol
Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.Glucotrol XL (glipizide) stimulates your body to release insulin and lower blood sugar.
Type of medication
glyburideGlucotrol
Prescription onlyPrescription only
Available as
glyburideGlucotrol
  • Pill
  • Pill
  • Extended release pill
Used for
glyburideGlucotrol
Risk factors for serious side effects
glyburideGlucotrol
  • Over age 65
  • Kidney problems
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
Detailed Diabeta (glyburide) risks & warnings »
  • Skipping meals or having inconsistent meal times
  • Drinking alcohol
  • Using other blood sugar-lowering medicine
  • People age 60 or older
  • Those with kidney and/or liver problems
Detailed Glucotrol XL (glipizide) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
glyburideGlucotrol
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
  • Avoid drinking alcohol while taking Glucotrol XL (glipizide).
Food
glyburideGlucotrol
  • Eat well-balanced meals to avoid low blood sugar.
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
Kidneys and liver
glyburideGlucotrol
  • Not ideal for elderly or those with poor kidney function.
  • People with kidney and/or liver problems take a longer time to get rid of Glucotrol XL (glipizide) from their body. They are more sensitive to the effects of low blood sugar that include symptoms such as fast heartbeat, sweating, pale skin, shakiness, confusion and irritability. They need to make sure to carry with them some form of sugar such as hard candies or glucose tablets at all times while they are on this medicine.
  • Can be used in those with kidney problems.
Weight
glyburideGlucotrol
  • Can cause weight gain, dizziness, or stomach upset.
  • Can cause weight gain (about 2 to 3 pounds).
  • Can cause mild weight gain of 2 to 3 pounds on average.
Upsides and benefits
glyburideGlucotrol
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
  • Lowers A1c levels by 1-2%. (A1c is a test that measures your average blood sugars over the past 3 months).
  • Glucotrol XL (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Can be used in those with kidney problems.
  • Available as a generic form and is relatively cheap.
Downsides and risks
glyburideGlucotrol
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • While taking Glucotrol XL (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
  • Can cause mild weight gain of 2 to 3 pounds on average.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
Tips from our pharmacists for people taking the medication
glyburideGlucotrol
  • Check your blood sugar regularly.
  • Eat well-balanced meals to avoid low blood sugar.
  • Works best if you take it 30 minutes before first main meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
  • Take the medicine 30 minutes before eating, usually before your first big meal of the day.
  • Avoid drinking alcohol while taking Glucotrol XL (glipizide).
  • Eat regular and well-balanced meals to keep your blood sugar levels normal.
  • Check your blood sugar regularly.
  • Glucotrol XL (glipizide) can cause dizziness so avoid activities that require coordination until you know how your body can handle the medicine.
Learn more
More about glyburideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Glucotrol XL (glipizide)?
Worth itNot sureNot worth it