Compare glyburide vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta (glyburide)

Prescription only

Glucotrol (glipizide)

Prescription only
Lowers blood sugar.

Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.

4.4/ 7 average rating with 110 reviewsforglyburide
Lowers blood sugar.

Glucotrol (glipizide) is an effective medicine for lowering blood sugar, but it can cause your blood sugar level to be too low so you must always carry some form of sugar with you that can be readily used.

4.3/ 7 average rating with 332 reviewsforGlucotrol
Upsides
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
  • Lowers A1c levels by 1-2%.
  • Glucotrol (glipizide) is an oral medicine so it might be a good alternative for those who don't like injections.
  • Protects your organs and blood vessels by preventing the harmful effects of high blood sugar levels.
  • Okay to use by people with kidney problems.
  • Available as a generic form and is relatively cheap.
Downsides
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
  • Has a higher risk than other diabetes medicine for causing blood sugar levels to be too low.
  • While taking Glucotrol (glipizide), your blood sugars should be checked 2 to 5 times a week, but less often once you are on a stable dose.
  • Can cause mild weight gain of 2-3lb.
  • Might lose its effectiveness over time.
  • Needs to be taken 30 minutes before a meal for it to be most effective.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release pill
Price
Lowest price near you
$10
Find instant savings
Lowest price near you
$9.99
Find instant savings
Want to save even more money?
Sign up now for a 30-day trial and save up to 95% at Kroger, Albertsons, Safeway, and other pharmacies.
Reviews
110 
45%
think this treatment is worth it
34%
think this treatment works well
21%
think this treatment is a hassle

Have you used Diabeta (glyburide)?

Leave a review
332 
50%
think this treatment is worth it
32%
think this treatment works well
19%
think this treatment is a hassle

Have you used Glucotrol (glipizide)?

Leave a review
Side effects
The Diabeta (glyburide) FDA package insert doesn’t have numbers about how common side effects are.
9possible side effects
  • Dizziness
    7%
  • Diarrhea
    5%
  • Nervousness
    4%
  • Tremor
    4%
  • Low blood sugar
    3%
  • Constipation
    3%
  • Passing gas
    3%
  • Nausea
    3%
  • Headache
    2%
See more detailed side effects
Risks and warnings
  • Low blood sugar

    Over age 65

    ...and 4 more risk factors

  • Severe allergic reactions

    History of sulfa allergies

See more detailed risks and warnings
  • Low blood sugar

    Skipping meals or having inconsistent meal times

    ...and 4 more risk factors

  • Severe allergic reaction

    History of allergy to sulfa-containing medicine

  • Kidney and liver disease

    Those with kidney and/or liver disease

  • Breakdown of red blood cells

    People with G6PD deficiency

See more detailed risks and warnings