Compare Glyburide vs. Glucotrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta
(Glyburide)

Glucotrol
(Glipizide)

Lowers blood sugar. Glyburide is a very effective oral blood sugar-lowering medicine, but has more side effects and restrictions compared to other medicines in this class (sulfonylureas).Lowers blood sugar. Glucotrol (Glipizide) is a very effective oral blood sugar-lowering medicine. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.4036697247706424Glyburide
Reviews for Diabeta (Glyburide)
46%
of people say Diabeta (Glyburide) is worth it
33%
say it works well
20%
say it's a big hassle
Reviews for Glucotrol (Glipizide)
50%
+4% vs. Diabeta (Glyburide)
32%
1% vs. Diabeta (Glyburide)
19%
+1% vs. Diabeta (Glyburide)
Side effects
GlyburideGlucotrol

The Glyburide FDA package insert doesn’t have numbers about how common side effects are.

More about Glyburide side effects »
  • Passing gas 2%
  • Dizziness 1%
  • Nervousness 1%
More Glucotrol side effects »
How it works
GlyburideGlucotrol
Glyburide is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Glucotrol (Glipizide) is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.
Type of medication
GlyburideGlucotrol
Anti-diabetic
Sulfonylurea
Prescription only
Anti-diabetic
Sulfonylurea
Prescription only
Available as
GlyburideGlucotrol
  • Pill
  • Pill
  • Extended release
Used for (click to learn more)
GlyburideGlucotrol
Risk factors for serious side effects
GlyburideGlucotrol
    • Elderly
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
    • History of sulfa allergies
    Detailed Diabeta (Glyburide) risks & warnings »
      • Use of other blood sugar lowering medicines
      • Alcohol
      • Intense physical activity
      • History of sulfa allergies
      Detailed Glucotrol (Glipizide) risks & warnings »
      Pregnancy category
      GlyburideGlucotrol
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      • Avoid drinking alcohol.
      • Avoid drinking alcohol.
      Food
      • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
      • Eat regular, balanced meals to avoid low blood sugar.
      • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
      • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
      • Eat regular, balanced meals to avoid low blood sugar.
      Kidneys and liver
      • Not a good choice for people with kidney problems because it's processed by the kidneys.
      • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      No specific sleep-related info.No specific sleep-related info.
      Weight
      • Can cause mild weight gain (2 to 3 pounds).
      • Can cause weight gain, dizziness, or stomach upset.
      • Can cause mild weight gain (2 to 3 pounds).
      • Can cause weight gain, dizziness, or stomach upset.
      Upsides and benefits
      GlyburideGlucotrol
      • Oral blood sugar-lowering medicine.
      • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
      • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
      • One of the least expensive diabetes medicines.
      • Might be a better choice for people with kidney problems compared to similar drugs because Glipizide isn't processed by the kidneys.
      • Oral blood sugar-lowering medicine.
      • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
      • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
      • One of the least expensive diabetes medicines.
      Downsides and risks
      GlyburideGlucotrol
      • Not preferred for people 65 years or older since it can cause prolonged low blood sugar (more than 12 hours).
      • Not a good choice for people with kidney problems because it's processed by the kidneys.
      • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
      • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
      • Can cause mild weight gain (2 to 3 pounds).
      • Loses effectiveness over time or as your body stops making insulin.
      • Food can cause unpredictable effects of the immediate-release version of Glipizide, so you have to take it at least 30 minutes before a meal.
      • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
      • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
      • Can cause mild weight gain (2 to 3 pounds).
      • Loses effectiveness over time or as your body stops making insulin.
      Tips from our pharmacists for people taking the medication
      GlyburideGlucotrol
      • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
      • Can cause weight gain, dizziness, or stomach upset.
      • Avoid drinking alcohol.
      • Eat regular, balanced meals to avoid low blood sugar.
      • Check your blood sugar regularly.
      • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
      • Can cause weight gain, dizziness, or stomach upset.
      • Avoid drinking alcohol.
      • Eat regular, balanced meals to avoid low blood sugar.
      • Check your blood sugar regularly.
      Learn more
      More about GlyburideSide effectsReviews & ratingsAlternativesFDA package insert
      More about GlucotrolSide effectsReviews & ratingsAlternativesFDA package insert