Compare Glyburide vs. Humalog

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta
(Glyburide)

Humalog
(Insulin Lispro)

Lowers blood sugar. Glyburide is a very effective oral blood sugar-lowering medicine, but has more side effects and restrictions compared to other medicines in this class (sulfonylureas).Lowers blood sugar. Humalog is a fast-acting insulin that provides meal-time sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.42Glyburide
Reviews for Diabeta (Glyburide)
45%
of people (All ages) say Diabeta (Glyburide) is worth it
34%
say it works well
21%
say it's a big hassle
110 reviews
Have you used Diabeta (Glyburide)?
Worth itNot sureNot worth it
Reviews for Humalog (Insulin Lispro)
64%
+19% vs. Diabeta (Glyburide)
50%
+16% vs. Diabeta (Glyburide)
16%
+5% vs. Diabeta (Glyburide)
280 reviews
Have you used Humalog (Insulin Lispro)?
Worth itNot sureNot worth it
Side effects
GlyburideHumalog

The Glyburide FDA package insert doesn’t have numbers about how common side effects are.

More about Glyburide side effects »

The Humalog FDA package insert doesn’t have numbers about how common side effects are.

More about Humalog side effects »
How it works
GlyburideHumalog
Glyburide is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Humalog is a short-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable after meals.
Type of medication
GlyburideHumalog
Anti-diabetic
Sulfonylurea
Prescription only
Anti-diabetic
Insulin
Prescription only
Available as
GlyburideHumalog
  • Pill
  • Injection
Used for (click to learn more)
GlyburideHumalog
Risk factors for serious side effects
GlyburideHumalog
  • Elderly
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
  • History of sulfa allergies
Detailed risks & warnings »
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
GlyburideHumalog
  • Avoid drinking alcohol.
No alcohol related info.
Food
GlyburideHumalog
  • Eat regular, balanced meals to avoid low blood sugar.
  • Short-acting insulin good for blood sugar control around meal times.
Kidneys and liver
GlyburideHumalog
  • Not a good choice for people with kidney problems because it's processed by the kidneys.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Weight
GlyburideHumalog
  • Can cause mild weight gain (2 to 3 pounds).
  • Can cause weight gain, dizziness, or stomach upset.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Can cause weight gain and low blood sugar.
Upsides and benefits
GlyburideHumalog
  • Oral blood sugar-lowering medicine.
  • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
  • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
  • One of the least expensive diabetes medicines.
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Humalog is a fast-acting insulin that provides sugar control after meals.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Downsides and risks
GlyburideHumalog
  • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
  • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
  • Can cause mild weight gain (2 to 3 pounds).
  • Not preferred for people 65 years or older since it can cause prolonged low blood sugar (more than 12 hours).
  • Not a good choice for people with kidney problems because it's processed by the kidneys.
  • Loses effectiveness over time or as your body stops making insulin.
  • You have to take insulin by injection.
  • You have to check your blood sugar multiple times every day, usually before each meal.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
Tips from our pharmacists for people taking the medication
GlyburideHumalog
  • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Avoid drinking alcohol.
  • Eat regular, balanced meals to avoid low blood sugar.
  • Check your blood sugar regularly.
  • Short-acting insulin good for blood sugar control around meal times.
  • Take 5 to 10 minutes before a meal. Effects last for 2-4 hours.
  • Can cause weight gain and low blood sugar.
  • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
  • Always have a good source of sugar nearby for low blood sugar episodes.
  • Make sure you understand how to give yourself the injections.
  • When mixing with another insulin (such as insulin NPH), draw this insulin into the syringe first.
  • Don't shake the vial. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
  • Check your blood sugar levels every day.
Learn more
More about GlyburideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Diabeta (Glyburide)?
Worth itNot sureNot worth it
More about HumalogSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Humalog (Insulin Lispro)?
Worth itNot sureNot worth it