Compare glyburide vs. Human Insulin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta
(glyburide)

Humulin
(human insulin)

Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for glyburide
Best available price for 60 (5mg) tablets of glyburide
Coupons for Human Insulin
Best available price for 15 (five 3ml kwikpens of 100 units/ml) cartons of humulin-n
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.42glyburide
Reviews for glyburide
45%
of people (All ages) say glyburide is worth it
34%
say it works well
21%
say it's a big hassle
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Reviews for Human Insulin
67%
-22% worse vs. glyburide
46%
-12% worse vs. glyburide
11%
-10% worse vs. glyburide
Have you used Humulin (human insulin)?
Worth itNot sureNot worth it
Side effects
glyburideHuman Insulin
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »

The Human Insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human Insulin side effects »
How it works
glyburideHuman Insulin
Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.
Type of medication
glyburideHuman Insulin
Prescription onlyPrescription only
Available as
glyburideHuman Insulin
  • Pill
  • Injection
  • Inhaler
Used for
glyburideHuman Insulin
Risk factors for serious side effects
glyburideHuman Insulin
  • Over age 65
  • Kidney problems
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
Detailed Diabeta (glyburide) risks & warnings »
    Detailed Humulin (human insulin) risks & warnings »
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Alcohol
    glyburideHuman Insulin
    • Try to avoid drinking alcohol while on Diabeta (glyburide).
    No alcohol related info.
    Food
    glyburideHuman Insulin
    • Eat well-balanced meals to avoid low blood sugar.
    No food related info.
    Kidneys and liver
    glyburideHuman Insulin
    • Not ideal for elderly or those with poor kidney function.
    No kidneys and liver related info.
    Weight
    glyburideHuman Insulin
    • Can cause weight gain, dizziness, or stomach upset.
    • Can cause weight gain (about 2 to 3 pounds).
    • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
    Upsides and benefits
    glyburideHuman Insulin
    • Available as an oral tablet.
    • Lowers your A1c (average blood sugar over time) up to 2%.
    • Available in generic version.
    • Available in single pill combination with other anti-diabetic medicines.
    • Some types of this medication are available without a prescription.
    • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
    • Available in different combinations so that you can do one shot or multiple shots a day.
    Downsides and risks
    glyburideHuman Insulin
    • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
    • You will have to check your blood sugar often when you first start taking it.
    • Can cause weight gain (about 2 to 3 pounds).
    • Not ideal for elderly or those with poor kidney function.
    • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
    • Has to be taken exactly as directed or it can cause high or low blood sugar.
    • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
    Tips from our pharmacists for people taking the medication
    glyburideHuman Insulin
    • Check your blood sugar regularly.
    • Eat well-balanced meals to avoid low blood sugar.
    • Works best if you take it 30 minutes before first main meal of the day.
    • Can cause weight gain, dizziness, or stomach upset.
    • Try to avoid drinking alcohol while on Diabeta (glyburide).
    • Change the location where you give yourself the shot every time.
    • Don't use if the liquid in the vial looks different than normal.
    • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
    • Take the medication exactly how your doctor tells you to.
    • Know the symptoms of low blood sugar.
    Learn more
    More about glyburideSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Diabeta (glyburide)?
    Worth itNot sureNot worth it
    More about Human InsulinSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Humulin (human insulin)?
    Worth itNot sureNot worth it