Compare glyburide vs. Human Insulin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta (glyburide)

Prescription only

Humulin (Human Insulin)

Prescription only
Lowers blood sugar.

Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.

4.4/ 7 average rating with 110 reviewsforglyburide
Lowers blood sugar.

This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.

5.0/ 7 average rating with 57 reviewsforHuman Insulin
Upsides
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
  • Some types of this medication are available without a prescription.
  • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
  • Available in different combinations so that you can do one shot or multiple shots a day.
Downsides
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
  • Has to be taken exactly as directed or it can cause high or low blood sugar.
  • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
Used for
Dosage forms
  • Pill
  • Injection
  • Inhaler
Price
Lowest price near you
$10
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Reviews
110 
45%
think this treatment is worth it
34%
think this treatment works well
21%
think this treatment is a hassle

Have you used Diabeta (glyburide)?

Leave a review
57 
67%
think this treatment is worth it
46%
think this treatment works well
11%
think this treatment is a hassle

Have you used Humulin (Human Insulin)?

Leave a review
Side effects
The Diabeta (glyburide) FDA package insert doesn’t have numbers about how common side effects are.
The Humulin (Human Insulin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Low blood sugar

    Over age 65

    ...and 4 more risk factors

  • Severe allergic reactions

    History of sulfa allergies

See more detailed risks and warnings