Compare Glyburide vs. Human Insulin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta
(glyburide)

Humulin
(human insulin)

Lowers blood sugar. Glyburide is a very effective oral blood sugar-lowering medicine, but has more side effects and restrictions compared to other medicines in this class (sulfonylureas).Lowers blood sugar. This form of insulin is one of the few medications in its class that you can get without a prescription, but it's expensive.
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Reviews & ratings
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4.42Glyburide
Reviews for Diabeta (glyburide)
45%
of people (All ages) say Diabeta (glyburide) is worth it
34%
say it works well
21%
say it's a big hassle
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Reviews for Humulin (human insulin)
67%
+22% better vs. Diabeta (glyburide)
46%
+12% better vs. Diabeta (glyburide)
11%
+10% better vs. Diabeta (glyburide)
Have you used Humulin (human insulin)?
Worth itNot sureNot worth it
Side effects
GlyburideHuman Insulin
  • Gastrointestinal disturbances 2%
  • Allergic skin reactions 2%
More Glyburide side effects »

The Human Insulin FDA package insert doesn’t have numbers about how common side effects are.

More about Human Insulin side effects »
How it works
GlyburideHuman Insulin
Glyburide is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Insulin is a hormone normally produced by your pancreas. It helps your body absorb and store sugar and fat from your bloodstream.
Type of medication
GlyburideHuman Insulin
Prescription only
Prescription only
Available as
GlyburideHuman Insulin
  • Pill
  • Injection
  • Inhaler
Used for
GlyburideHuman Insulin
Risk factors for serious side effects
GlyburideHuman Insulin
    • Elderly
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
    • History of sulfa allergies
    Detailed Diabeta (glyburide) risks & warnings »
          Detailed Humulin (human insulin) risks & warnings »
          Pregnancy

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Alcohol
          GlyburideHuman Insulin
          • Avoid drinking alcohol.
          No alcohol related info.
          Food
          GlyburideHuman Insulin
          • Eat regular, balanced meals to avoid low blood sugar.
          No food related info.
          Kidneys and liver
          GlyburideHuman Insulin
          • Not a good choice for people with kidney problems because it's processed by the kidneys.
          No kidneys and liver related info.
          Weight
          GlyburideHuman Insulin
          • Can cause mild weight gain (2 to 3 pounds).
          • Can cause weight gain, dizziness, or stomach upset.
          • People on Humulin (Human Insulin) can experience weight gain. Talk to your doctor or dietitian about changing your diet if this bothers you.
          Upsides and benefits
          GlyburideHuman Insulin
          • Oral blood sugar-lowering medicine.
          • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
          • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
          • One of the least expensive diabetes medicines.
          • Some types of this medication are available without a prescription.
          • Available as a shot to be injected into the fatty part of the skin, and as a powder to be inhaled through your nose.
          • Available in different combinations so that you can do one shot or multiple shots a day.
          Downsides and risks
          GlyburideHuman Insulin
          • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
          • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
          • Can cause mild weight gain (2 to 3 pounds).
          • Not preferred for people 65 years or older since it can cause prolonged low blood sugar (more than 12 hours).
          • Not a good choice for people with kidney problems because it's processed by the kidneys.
          • Loses effectiveness over time or as your body stops making insulin.
          • Has to be taken exactly as directed or it can cause high or low blood sugar.
          • As with all insulins, you have to work with your doctor closely to make sure you're giving yourself the correct dose, or you can have low or high blood sugar.
          Tips from our pharmacists for people taking the medication
          GlyburideHuman Insulin
          • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
          • Can cause weight gain, dizziness, or stomach upset.
          • Avoid drinking alcohol.
          • Eat regular, balanced meals to avoid low blood sugar.
          • Check your blood sugar regularly.
          • Change the location where you give yourself the shot every time.
          • Don't use if the liquid in the vial looks different than normal.
          • Store the unopened vials in the refrigerator. The used vials can be kept at room temperature for up to 28 days.
          • Take the medication exactly how your doctor tells you to.
          • Know the symptoms of low blood sugar.
          Learn more
          More about GlyburideSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Diabeta (glyburide)?
          Worth itNot sureNot worth it
          More about Human InsulinSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Humulin (human insulin)?
          Worth itNot sureNot worth it