Compare Glyburide vs. Janumet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta
(Glyburide)

Janumet
(Sitagliptin / Metformin)

Lowers blood sugar. Glyburide is a very effective oral blood sugar-lowering medicine, but has more side effects and restrictions compared to other medicines in this class (sulfonylureas).Lowers blood sugar. Janumet is an expensive but very effective combination of oral blood sugar-lowering medicines.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.4036697247706424Glyburide
Reviews for Diabeta (Glyburide)
46%
of people say Diabeta (Glyburide) is worth it
33%
say it works well
20%
say it's a big hassle
Reviews for Janumet (Sitagliptin / Metformin)
44%
2% vs. Diabeta (Glyburide)
36%
+3% vs. Diabeta (Glyburide)
16%
+4% vs. Diabeta (Glyburide)
Side effects
GlyburideJanumet

The Glyburide FDA package insert doesn’t have numbers about how common side effects are.

More about Glyburide side effects »
  • Diarrhea 4%
  • Nausea 4%
  • Headache 3%
  • Abdominal pain 1%
  • Ear, nose, or throat infection 1%
More Janumet side effects »
How it works
GlyburideJanumet
Glyburide is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Janumet is an antidiabetic combination medicine. Metformin lowers the amount of sugar your body produces, and sitagliptin helps your body release more insulin.
Type of medication
GlyburideJanumet
Anti-diabetic
Sulfonylurea
Prescription only
Anti-diabetic
DPP-4 inhibitor
Biguanide
Prescription only
Available as
GlyburideJanumet
  • Pill
  • Pill
  • Extended release
Used for (click to learn more)
GlyburideJanumet
Risk factors for serious side effects
GlyburideJanumet
    • Elderly
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
    • History of sulfa allergies
    Detailed Diabeta (Glyburide) risks & warnings »
    • Kidney problems
    • Liver problems
    • Congestive heart failure
    • Contrast dye for procedure
    • Surgery
    • Alcohol use
          Detailed Janumet (Sitagliptin / Metformin) risks & warnings »
          Pregnancy category
          GlyburideJanumet
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          • Avoid drinking alcohol.
          No specific alcohol-related info.
          Food
          • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
          • Eat regular, balanced meals to avoid low blood sugar.
          • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
          Kidneys and liver
          • Not a good choice for people with kidney problems because it's processed by the kidneys.
          • People with poor kidney function can't use it.
          • Janumet (Sitagliptin / Metformin) can cause this rare but life-threatening condition. Symptoms include deep and rapid breathing, nausea, vomiting, and stomach pain. This is a medical emergency and you should get help right away. Baseline blood work for kidney and liver function are helpful to see if you can use Janumet (Sitagliptin / Metformin). It may not be a good choice for people with kidney problems. Janumet (Sitagliptin / Metformin) should be stopped 48 hours before and/or after surgery or any imaging procedure needing contrast dye.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          • Can cause mild weight gain (2 to 3 pounds).
          • Can cause weight gain, dizziness, or stomach upset.
          • Doesn't cause weight gain or low blood sugar.
          Upsides and benefits
          GlyburideJanumet
          • Oral blood sugar-lowering medicine.
          • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
          • One of the least expensive diabetes medicines.
          • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
          • 2-in-1 combination medicine. If you need more than one blood sugar medicine, this lowers the number of pills you have to take.
          • Lowers A1c levels by 1-2.5%. (Hemoglobin A1c measures your average blood sugar over time.)
          • Doesn't cause weight gain or low blood sugar.
          • You don't have to check your blood sugar every day with this medicine.
          • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
          Downsides and risks
          GlyburideJanumet
          • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
          • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
          • Can cause mild weight gain (2 to 3 pounds).
          • Not preferred for people 65 years or older since it can cause prolonged low blood sugar (more than 12 hours).
          • Not a good choice for people with kidney problems because it's processed by the kidneys.
          • Loses effectiveness over time or as your body stops making insulin.
          • Likely expensive since there's no generic version available.
          • The metformin part of Janumet can cause nausea, indigestion, or diarrhea for most people in the first few weeks.
          • People with poor kidney function can't use it.
          • The sitagliptin part of Janumet can cause some people to have frequent throat infections or nasal congestion.
          • Might raise the risk of problems with your pancreas.
          Tips from our pharmacists for people taking the medication
          GlyburideJanumet
          • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
          • Can cause weight gain, dizziness, or stomach upset.
          • Avoid drinking alcohol.
          • Eat regular, balanced meals to avoid low blood sugar.
          • Check your blood sugar regularly.
          • Take it with food to avoid upset stomach with diarrhea, nausea, and vomiting.
          • May cause headaches and cold-like symptoms.
          • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
          • Can be expensive depending on insurance coverage.
          • Check your blood sugar regularly.
          Learn more
          More about GlyburideSide effectsReviews & ratingsAlternativesFDA package insert
          More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert