Compare glyburide vs. Janumet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta
(glyburide)

Janumet
(sitagliptin / metformin)

Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.Lowers your blood sugar. Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.
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Coupons for glyburide
Best available price for 60 (5mg) tablets of glyburide
Coupons for Janumet
Best available price for 60 (50mg/1000mg) tablets of janumet
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.42glyburide
Reviews for glyburide
45%
of people (All ages) say glyburide is worth it
34%
say it works well
21%
say it's a big hassle
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Reviews for Janumet
46%
-1% worse vs. glyburide
38%
-4% worse vs. glyburide
15%
-6% worse vs. glyburide
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it
Side effects
glyburideJanumet
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
  • Low blood sugar 15%
  • Diarrhea 4%
  • Ear, nose, or throat infection 1%
  • Headache 3%
More Janumet side effects »
How it works
glyburideJanumet
Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.Janumet (sitagliptin / metformin) is a combination of two anti-diabetic medicines. Metformin lowers the amount of sugar your body produces, and sitagliptin enhances the release of insulin.
Type of medication
glyburideJanumet
Prescription onlyPrescription only
Available as
glyburideJanumet
  • Pill
  • Pill
  • Extended release
Used for
glyburideJanumet
Risk factors for serious side effects
glyburideJanumet
  • Over age 65
  • Kidney problems
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
Detailed Diabeta (glyburide) risks & warnings »
  • Kidney problems
  • Liver problems
  • Congestive heart failure
  • Using contrast dye for procedures
  • Surgery
Detailed Janumet (sitagliptin / metformin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
glyburideJanumet
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
No alcohol related info.
Food
glyburideJanumet
  • Eat well-balanced meals to avoid low blood sugar.
  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
Kidneys and liver
glyburideJanumet
  • Not ideal for elderly or those with poor kidney function.
  • Not appropriate for those with poor kidney function.
Weight
glyburideJanumet
  • Can cause weight gain, dizziness, or stomach upset.
  • Can cause weight gain (about 2 to 3 pounds).
No weight related info.
Upsides and benefits
glyburideJanumet
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
  • This 2-in-1 combination can lower the number of pills you have to take daily.
  • Lowers A1c (average blood sugar over time) up to 2.5%.
  • Available in extended and immediate release forms to allow better control of your blood sugar.
  • Doesn't increase your appetite unlike other anti-diabetic medicines.
  • Does not cause hypoglycemia or very low blood sugar.
Downsides and risks
glyburideJanumet
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
  • Available as brand name only and may be expensive.
  • Metformin component usually causes upset stomach.
  • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
  • Not appropriate for those with poor kidney function.
Tips from our pharmacists for people taking the medication
glyburideJanumet
  • Check your blood sugar regularly.
  • Eat well-balanced meals to avoid low blood sugar.
  • Works best if you take it 30 minutes before first main meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
  • Take with food to avoid upset stomach with diarrhea, nausea, and vomiting.
  • May cause headaches and cold-like symptoms.
  • Tell your doctor about any deep or rapid breathing, or persistent nausea, vomiting, and stomach pain.
  • Can be expensive depending on insurance coverage.
  • Check your blood sugar regularly.
Learn more
More about glyburideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
More about JanumetSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Janumet (sitagliptin / metformin)?
Worth itNot sureNot worth it