Compare glyburide vs. Janumet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta (glyburide)

Prescription only
Lowers blood sugar.

Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.

4.4/ 7 average rating with 110 reviewsforglyburide
Lowers your blood sugar.

Janumet is a combination of two anti-diabetic medicines that work better together, but is available as brand only.

4.5/ 7 average rating with 79 reviewsforJanumet
Upsides
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
  • This 2-in-1 combination can lower the number of pills you have to take daily.
  • Lowers A1c (average blood sugar over time) up to 2.5%.
  • Available in extended and immediate release forms to allow better control of your blood sugar.
  • Doesn't increase your appetite unlike other anti-diabetic medicines.
  • Does not cause hypoglycemia or very low blood sugar.
Downsides
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
  • Available as brand name only and may be expensive.
  • Metformin component usually causes upset stomach.
  • Sitagliptin component may increase your risk for throat infections and inflammation of pancreas.
  • Not appropriate for those with poor kidney function.
Used for
Dosage forms
  • Pill
  • Pill
  • Extended release
Price
Lowest price near you
$10
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Lowest price near you
$415.3
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Reviews
110 
45%
think this treatment is worth it
34%
think this treatment works well
21%
think this treatment is a hassle

Have you used Diabeta (glyburide)?

Leave a review
79 
46%
think this treatment is worth it
38%
think this treatment works well
15%
think this treatment is a hassle

Have you used Janumet (sitagliptin / metformin)?

Leave a review
Side effects
The Diabeta (glyburide) FDA package insert doesn’t have numbers about how common side effects are.
The Janumet (sitagliptin / metformin) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Low blood sugar

    Over age 65

    ...and 4 more risk factors

  • Severe allergic reactions

    History of sulfa allergies

See more detailed risks and warnings
  • Excess lactic acid in the blood

    Kidney problems

    ...and 5 more risk factors

See more detailed risks and warnings