Compare glyburide vs. Januvia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta
(glyburide)

Januvia
(sitagliptin)

Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.Lowers your blood sugar. Januvia (sitagliptin) is a good add-on treatment if your blood sugars are not controlled and you don't want to use an injectable medicine.
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Coupons for glyburide
Best available price for 60 (5mg) tablets of glyburide
Coupons for Januvia
Best available price for 30 (100mg) tablets of januvia
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.42glyburide
Reviews for glyburide
45%
of people (All ages) say glyburide is worth it
34%
say it works well
21%
say it's a big hassle
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Reviews for Januvia
44%
+1% better vs. glyburide
34%
Same vs. glyburide
17%
-4% worse vs. glyburide
143 reviews
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it
Side effects
glyburideJanuvia
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
  • Common cold 2%
  • Diarrhea 1%
  • Upper respiratory infection 3%
  • Headache 1%
More Januvia side effects »
How it works
glyburideJanuvia
Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.Januvia (sitagliptin) is an anti-diabetic drug that enhances your body's release of insulin.
Type of medication
glyburideJanuvia
Prescription onlyPrescription only
Available as
glyburideJanuvia
  • Pill
  • Pill
Used for
glyburideJanuvia
Risk factors for serious side effects
glyburideJanuvia
  • Over age 65
  • Kidney problems
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
Detailed Diabeta (glyburide) risks & warnings »
  • History of pancreatitis
  • High blood triglyceride levels
  • Gallstones (stones in gallbladder)
  • History of alchoholism
  • Kidney problems
Detailed Januvia (sitagliptin) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
glyburideJanuvia
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
No alcohol related info.
Food
glyburideJanuvia
  • Eat well-balanced meals to avoid low blood sugar.
  • Take once a day in the morning with or without food.
Kidneys and liver
glyburideJanuvia
  • Not ideal for elderly or those with poor kidney function.
  • Januvia (sitagliptin) can worsen kidney problems. Your doctor may check your kidney function before and during treatment. Your doctor may have to adjust the dose or stop this medicine based on changes in kidney function.
Pain
glyburideJanuvia
No pain related info.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
Weight
glyburideJanuvia
  • Can cause weight gain (about 2 to 3 pounds).
  • Can cause weight gain, dizziness, or stomach upset.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
Upsides and benefits
glyburideJanuvia
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
  • Oral blood sugar-lowering medicine.
  • Januvia (sitagliptin) is not linked to worsening heart failure like other medicines in its class.
  • Uses the hormones naturally produced by your body to affect how sugar is processed.
  • It is less likely to cause weight gain and low blood sugar compared to other diabetes medicines.
Downsides and risks
glyburideJanuvia
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
  • Lowers A1c (average blood sugar over time) by less than 1%.
  • Available as brand version only.
  • Some people might get frequent cold-like symptoms.
  • Rare but serious side effects include pancreatitis and severe joint pain.
Tips from our pharmacists for people taking the medication
glyburideJanuvia
  • Check your blood sugar regularly.
  • Eat well-balanced meals to avoid low blood sugar.
  • Works best if you take it 30 minutes before first main meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
  • Take once a day in the morning with or without food.
  • Can cause headache and cold-like symptoms.
  • Tell your doctor right away if you have severe stomach pain, nausea, and/or vomiting. These are symptoms of pancreatitis.
  • Tell your doctor right away if you are experiencing severe joint pain.
  • Check your blood sugar regularly to check for low blood sugar.
Learn more
More about glyburideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Januvia (sitagliptin)?
Worth itNot sureNot worth it