Compare Glyburide vs. Januvia

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta
(Glyburide)

Januvia
(Sitagliptin)

Lowers blood sugar. Glyburide is a very effective oral blood sugar-lowering medicine, but has more side effects and restrictions compared to other medicines in this class (sulfonylureas).Lowers blood sugar. Januvia (Sitagliptin) is a good add-on treatment if your blood sugar is still too high, but you don't want to use an injectable medicine.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.4036697247706424Glyburide
Reviews for Diabeta (Glyburide)
46%
of people say Diabeta (Glyburide) is worth it
33%
say it works well
20%
say it's a big hassle
Reviews for Januvia (Sitagliptin)
43%
3% vs. Diabeta (Glyburide)
34%
+1% vs. Diabeta (Glyburide)
17%
+3% vs. Diabeta (Glyburide)
Side effects
GlyburideJanuvia

The Glyburide FDA package insert doesn’t have numbers about how common side effects are.

More about Glyburide side effects »
  • Common cold 2%
  • Diarrhea 1%
More Januvia side effects »
How it works
GlyburideJanuvia
Glyburide is an anti-diabetic drug. It stimulates your body to make more insulin to lower blood sugar.Januvia (Sitagliptin) is an anti-diabetic drug. It helps your body release more insulin in order to lower blood sugar.
Type of medication
GlyburideJanuvia
Anti-diabetic
Sulfonylurea
Prescription only
Anti-diabetic
DPP-4 inhibitor
Prescription only
Available as
GlyburideJanuvia
  • Pill
  • Pill
Used for (click to learn more)
GlyburideJanuvia
Risk factors for serious side effects
GlyburideJanuvia
    • Elderly
    • Use of other blood sugar lowering medicines
    • Alcohol
    • Intense physical activity
    • History of sulfa allergies
    Detailed Diabeta (Glyburide) risks & warnings »
        Detailed Januvia (Sitagliptin) risks & warnings »
        Pregnancy category
        GlyburideJanuvia
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        Alcohol
        • Avoid drinking alcohol.
        No specific alcohol-related info.
        Food
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • Eat regular, balanced meals to avoid low blood sugar.
        No specific food-related info.
        Kidneys and liver
        • Not a good choice for people with kidney problems because it's processed by the kidneys.
        No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.
        Weight
        • Can cause mild weight gain (2 to 3 pounds).
        • Can cause weight gain, dizziness, or stomach upset.
        • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
        Upsides and benefits
        GlyburideJanuvia
        • Lowers A1c levels by 1-2%. (Hemoglobin A1c measures your average blood sugar over time.)
        • One of the least expensive diabetes medicines.
        • Oral blood sugar-lowering medicine.
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        • Lowers A1c levels by 0.5-0.8%. (Hemoglobin A1c measures your average blood sugar over time.)
        • Uses the hormones naturally produced by your body to affect how sugar is processed.
        • Unlike some diabetes medicines, it's unlikely to cause weight gain and low blood sugar.
        • You don't have to check your blood sugar every day with this medicine.
        • Oral blood sugar-lowering medicine.
        • Prevents the harmful effects of high sugar levels on your organs and blood vessels.
        Downsides and risks
        GlyburideJanuvia
        • Higher risk of low blood sugar episodes than other kinds of oral diabetes medicines.
        • You have to check your blood sugar 2 to 5 times a week (less often once you are on a stable dose).
        • Can cause mild weight gain (2 to 3 pounds).
        • Not preferred for people 65 years or older since it can cause prolonged low blood sugar (more than 12 hours).
        • Not a good choice for people with kidney problems because it's processed by the kidneys.
        • Loses effectiveness over time or as your body stops making insulin.
        • Not as strong as other diabetes medicines. Your doctor might add it to your blood sugar-lowering regimen if your sugar levels are still too high.
        • Likely expensive since there's no generic version available.
        • Some people might get frequent throat infections or nasal congestion.
        Tips from our pharmacists for people taking the medication
        GlyburideJanuvia
        • Works best if you take it 30 minutes before a meal, usually your first big meal of the day.
        • Can cause weight gain, dizziness, or stomach upset.
        • Avoid drinking alcohol.
        • Eat regular, balanced meals to avoid low blood sugar.
        • Check your blood sugar regularly.
        • Can cause headache and cold-like symptoms.
        • Tell your doctor about persistent stomach pain, nausea, vomiting, or loss of appetite.
        • Can be expensive depending on insurance coverage.
        • Check your blood sugar regularly.
        Learn more
        More about GlyburideSide effectsReviews & ratingsAlternativesFDA package insert
        More about JanuviaSide effectsReviews & ratingsAlternativesFDA package insert