Compare glyburide vs. Lantus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta (glyburide)

Prescription only

Lantus (Insulin Glargine)

Prescription only
Lowers blood sugar.

Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.

4.4/ 7 average rating with 110 reviewsforglyburide
Lowers blood sugar.

Lantus (Insulin Glargine) is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.

5.1/ 7 average rating with 584 reviewsforLantus
Upsides
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Lantus is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Downsides
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
  • You have to take insulin by injection.
  • You have to check your blood sugar every day.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
Used for
Dosage forms
  • Pill
  • Injection
Price
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$10
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$389.68
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Reviews
110 
45%
think this treatment is worth it
34%
think this treatment works well
21%
think this treatment is a hassle

Have you used Diabeta (glyburide)?

Leave a review
584 
67%
think this treatment is worth it
51%
think this treatment works well
14%
think this treatment is a hassle

Have you used Lantus (Insulin Glargine)?

Leave a review
Side effects
The Diabeta (glyburide) FDA package insert doesn’t have numbers about how common side effects are.
2possible side effects
  • Angiopathy
    7%
  • Injection site pain
    3%
See more detailed side effects
Risks and warnings
  • Low blood sugar

    Over age 65

    ...and 4 more risk factors

  • Severe allergic reactions

    History of sulfa allergies

See more detailed risks and warnings
  • Life-threatening low blood sugar (Hypoglycemia)

    Insulin dose too high

    ...and 4 more risk factors

  • Complications due to low potassium

    Use of other medicine that lowers potassium

    ...and 1 more risk factors

See more detailed risks and warnings