Compare glyburide vs. Lantus

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Diabeta
(glyburide)

Lantus
(insulin glargine)

Lowers blood sugar. Diabeta (glyburide) is a good oral anti-diabetic medicine, but can cause hypoglycemia or low blood sugar.Lowers blood sugar. Lantus (Insulin Glargine) is a long-acting insulin that provides all-day sugar control. It can cause low blood sugar, so make sure you know what the symptoms are and always have a source of sugar nearby.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.42glyburide
Reviews for glyburide
45%
of people (All ages) say glyburide is worth it
34%
say it works well
21%
say it's a big hassle
110 reviews
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
Reviews for Lantus
67%
-22% worse vs. glyburide
51%
-17% worse vs. glyburide
14%
-7% worse vs. glyburide
584 reviews
Have you used Lantus (insulin glargine)?
Worth itNot sureNot worth it
Side effects
glyburideLantus
  • Nausea and heartburn 2%
  • Skin allergies 2%
More glyburide side effects »
  • Ear, nose, or throat infection 22%
  • Infection 9%
  • Accidental injury 6%
  • Headache 6%
  • Ankle and leg swelling 20%
  • High blood pressure 20%
  • Sinus inflammation 19%
  • Flu 19%
  • Clouded eye lens 18%
  • Bronchitis 15%
More Lantus side effects »
How it works
glyburideLantus
Diabeta (glyburide) stimulates your body to release insulin and lower blood sugar.Lantus (Insulin Glargine) is a long-acting insulin medicine for diabetes. It acts like the insulin that your body normally makes to process sugars and fats, and it keeps your blood sugar stable throughout the day.
Type of medication
glyburideLantus
Prescription onlyPrescription only
Available as
glyburideLantus
  • Pill
  • Injection
Used for
glyburideLantus
Risk factors for serious side effects
glyburideLantus
  • Over age 65
  • Kidney problems
  • Use of other blood sugar lowering medicines
  • Alcohol
  • Intense physical activity
Detailed Diabeta (glyburide) risks & warnings »
  • Insulin dose too high
  • Use of other blood sugar lowering medicines
  • Poor injection techniques
  • Unstable kidney functions
  • Unstable liver functions
Detailed Lantus (insulin glargine) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
glyburideLantus
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
No alcohol related info.
Food
glyburideLantus
  • Eat well-balanced meals to avoid low blood sugar.
No food related info.
Kidneys and liver
glyburideLantus
  • Not ideal for elderly or those with poor kidney function.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Weight
glyburideLantus
  • Can cause weight gain, dizziness, or stomach upset.
  • Can cause weight gain (about 2 to 3 pounds).
  • Can cause weight gain and low blood sugar.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
Upsides and benefits
glyburideLantus
  • Available as an oral tablet.
  • Lowers your A1c (average blood sugar over time) up to 2%.
  • Available in generic version.
  • Available in single pill combination with other anti-diabetic medicines.
  • Insulin is the most effective blood sugar-lowering medicine. When used correctly, it'll lower blood sugar every time you use it and prevent the harmful effects of high sugar levels on your organs and blood vessels.
  • Lantus is a long-lasting insulin that provides consistent, all-day sugar control with less risk of low blood sugar.
  • Dose can be easily adjusted to make a customized regimen that's tailored to your body.
  • Starting insulin early in the treatment of Type 2 diabetes can maintain your body's insulin-producing cells and slow down disease progression.
  • Okay to use even if you have liver or kidney problems, unlike most other blood sugar-lowering medicines.
Downsides and risks
glyburideLantus
  • More likely to cause hypoglycemia or low blood sugar than other types of oral anti-diabetics.
  • You will have to check your blood sugar often when you first start taking it.
  • Can cause weight gain (about 2 to 3 pounds).
  • Not ideal for elderly or those with poor kidney function.
  • May not work as well for those with severe diabetes and when pancreas cannot produce insulin.
  • You have to take insulin by injection.
  • You have to check your blood sugar every day.
  • Likely to cause moderate weight gain (around 4 to 6 pounds).
  • Higher risk of low blood sugar episodes than other kinds of diabetes medicines.
Tips from our pharmacists for people taking the medication
glyburideLantus
  • Check your blood sugar regularly.
  • Eat well-balanced meals to avoid low blood sugar.
  • Works best if you take it 30 minutes before first main meal of the day.
  • Can cause weight gain, dizziness, or stomach upset.
  • Try to avoid drinking alcohol while on Diabeta (glyburide).
  • Long-acting insulin good for baseline blood sugar control.
  • Works in 1 hour and lasts about 24 hours.
  • Can cause weight gain and low blood sugar.
  • Make sure you and your family know the symptoms of low blood sugar: sweating, shakiness, weakness, fast heartbeat, nervousness, headache, blurry vision, trouble thinking clearly, or passing out.
  • Always have a good source of sugar nearby for low blood sugar episodes.
  • Take it at the same time every day.
  • Make sure you understand how to give yourself the injections.
  • Don't shake the vial or mix with another insulin. Store unopened vials in the refrigerator. Opened vials are good at room temperature for 28 days.
  • Check your blood sugar levels every day.
Learn more
More about glyburideSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Diabeta (glyburide)?
Worth itNot sureNot worth it
More about LantusSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Lantus (insulin glargine)?
Worth itNot sureNot worth it